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Medicinal Chemistry Research Discipline

Medicinal Chemistry at the School of Pharmacy and Pharmaceutical Sciences


Design and synthesis of novel active compounds as drug candidates

(Coordinator, Andy Westwell )

Expertise includes: computer-based molecular graphics, synthesis and analysis of bioactive molecules, applying a wide variety of spectroscopic and other analytical methods. This research group enjoys well-equipped laboratories.  
There is close collaboration with virologists and biochemists throughout Europe and the USA.


Specialist Facilities: The Cardiff School of Pharmacy and Pharmaceutical Sciences has excellent facilities for Medicinal Chemistry. In 2005, we purchased a multi-nuclear Bruker 500MHz NMR spectrometer, and a Bruker micro TOF mass spectrometer (set up for Atmospheric Pressure Chemical Ionisation (APCI) and microspray). 
The synthetic chemistry laboratories are modern and each researcher has their own fumehood. 
We also have extensive molecular modelling hardware and software, as well as access to state of the art molecular graphics facilities within the University.

 

Current research interests include:
-
molecular modelling
- nucleotide prodrugs (“Protides”) especially as anticancer and antiviral agents

 

Latest News
Professor Chris McGuigan and Professor Malcolm Mason
Ser Cymru, the National Research Network in Health and Life Sciences is launched

05/09/2013

Professor Chris McGuigan and Professor Malcolm Mason to lead the network.

 

Prof. Chris McGuigan
Anti-cancer ProTide NUC1031 successful in first human trials

07/06/2013

Compound helps overcome the body's resistance to cancer drug Gemcitabine.

 

Staff Photo of Dr Andrea Brancale
Prestigious William Prusoff Award given to Andrea Brancale

14/03/2013

Prize recognises outstanding scientists demonstrating dedication, excellence and future potential in the field of antiviral research.

 

3D structure/image of NUC-1031 anti-cancer drug based on gemcitabine
First anti-cancer Pro-tide drug from the McGuigan laboratory is tested in humans

21/01/2013

Nucana BioMed have commenced a phase 1 trial of NUC 1031 against pancreatic cancer.

 

Prof McGuigan with the "Cardiff Inhibitex team" in the laboratory 2011
Bristol-Myers Squibb to acquire Inhibitex

09/01/2012

The deal includes rights to two drugs discovered in Cardiff.

 

 

Andrew Lim awarded Commended Poster Prize at the 2011 UK PharmSci conference in Nottingham
Recognition for undergraduate pharmacy student at the UK PharmSci Conference

16/09/2011

Andrew Lim, who starts his final year in October, was awarded a Commended Poster Prize in Nottingham (Sept. 2011).

 

Prof McGuigan with the "Cardiff Inhibitex team" in the laboratory 2011
A major step forward for potential anti-Hepatitis C drug, INX-189, orginally synthesised in Cardiff

22/03/2011

A novel 'Pro Tide' drug, first synthesised in the Welsh School of Pharmacy less than 3 years ago, has been successfully tested in hepatitis C patients   by the U.S. biopharmaceutical company Inhibitex.

 

Presidents Scholars in Drug Discovery & development - group with speakers
President's Research Scholars in Drug Discovery & development report findings after 4 months

The six scholars present posters at the Entrepreneurship symposium.