Wednesday, 26th February 2014
Starts: 26 February 2014
Dr Steve Clark
Cardiff School of Pharmacy and Pharmaceutical Science
Trapping Pathogens in NETs – Neutrophil Defences Turned Inside-Out
I have always been interested in basic science that has direct relevance to human diseases. In the course of my PhD I studied innate immune cell regulation of nitric oxide signalling in cardiovascular disease.
During my post-doctoral training at the University of Calgary, Alberta. I investigated the interaction of platelets with neutrophils during systemic infection. This work was the first to suggest that neutrophils extracellular traps (NETs) could be formed within the vasculature and ensnare circulating bacteria during sepsis.
My research since 2007 has concentrated on the role of NETs in disease and the processes that regulate NET formation. I have identified a new class of neutrophil-derived eicosanoids that inhibit NET formation. With Gavin Wilkinson, I have also investigated the role of innate immune cells including NK cells, dendritic cells and neutrophils in cytomegalovirus infection (including neutralisation of virus by NETs).
Appointed as Lecturer in the Cardiff School of Pharmacy and Pharmaceutical Sciences in January 2014.
Redwood 2.60c (NLT)
1.30pm. Refreshments from 1:20pm
Open To: Public
Staff and Students