Wednesday, 13th November 2013
Starts: 13 November 2013
Professor Sylvie Urbe
Control of receptor trafficking and signalling by reversible ubiquitylation
I have been a Principal Investigator in the Physiological Laboratory at the University of Liverpool since April 2002, where I held first a Wellcome Trust Career Development Award, and from 2006, Cancer Research UK Senior Fellowship, which allowed me to further expand my group.
I am particularly interested in the role of reversible ubiquitylation in the regulation of trafficking and signalling of growth factor receptors. Amongst the receptors, which we have been studying, are members of the EGF receptor superfamily of receptor tyrosine kinases, c-Met and the TGFß receptor superfamily of serine-threonine kinase receptors. Our work on a class of proteases, called deubiquitylases (DUBs), that remove ubiquitin from target proteins, has provided the first demonstration for in vitro specificity of these enzymes and established new paradigms for their role in the down-regulation of growth factor receptors. More recently, we have expanded our interest in this area to encompass the full complement of DUBs encoded in the human genome. As key modulators of both signalling and stability of oncoproteins and tumour suppressors, DUBs have become recognized as potential new targets for small inhibitor based drug therapies and are of considerable interest from a translational point of view.
Together with my long-term collaborator Michael Clague, we have generated a comprehensive set of tools to study these enzymes and characterize their role in a diverse range of cellular functions, in particular membrane traffic, signal transduction and microtubule dynamics.
Redwood 2.60c (NLT)
1.30pm. Refreshments from 1:20pm
Open To: Public
Staff and Students