Welsh School of Pharmacy

siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat.

Al Soraj, M, Peynshaert, K., He, L, Cousaert, J., Vercauteren, D., Braeckmans, K., De Smedt, S.C. and Jones, A.T.

Journal of Controlled Release (2012), 161(1), p132-141.

Contribution of spores to the ability of Clostridium difficile to adhere to surfaces.

Joshi LT, Phillips DS, Williams CF, Alyousef A, and Baillie L

Applied and Environmental Microbiology (2012), 78(21), p7671–7679.

Dose-dependent change in biomarkers during neoadjuvant endocrine therapy with fulvestrant: results from NEWEST, a randomized Phase II study.

Kuter I, Gee JM, Hegg R, Singer CF, Badwe RA, Lowe ES, Emeribe UA, Anderson E, Sapunar F, Finlay P, Nicholson RI, Bines J, Harbeck N.

Breast Cancer Res Treat. 2012 Jan 28. [Epub ahead of print]

Protein Kinase CK2 Triggers Cytosolic Zinc Signaling Pathways by Phosphorylation of Zinc Channel ZIP7.

Taylor, K.M., Hiscox, S., Nicholson, R.I., Hogstrand, C., Kille, P.

Science Signalling DOI:10.1126/scisignal.2002585 (2011).

Co-operative membrane disruption between cell penetrating peptide and cargo - implications for the therapeutic use of the Bcl-2 converter peptide D-NuBCP-9-r8.

Watkins, C.L., Sayers, E.J., Allender, C., Barrow, D., Fegan, C., Brennan, P., Jones, A.T. 

Molecular Therapy DOI:10.1038/mt.2011.175 (2011).