Dr Stephen R Clark
I am a Lecturer in Immunopharmacology at the School of Pharmacy & Pharmaceutical Sciences, Cardiff University, where I run a laboratory focused on innate cellular immune defences against invading microorganisms.
My interests include anti-microbial defences of neutrophils and the neutrophil extracellular traps (NETs) that they produce. NETs are formed when activated neutrophils release large web-like structures of DNA decorated with granule proteins. Formation of NETs is an important protective anti-microbial response to bacteria, fungi and viruses but occurs at the expense of tissue injury. I am particular keen to understand how the formation of NETs is controlled and limited during many forms of neutrophil activation.
Member of the Critical Illness Research Group