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Dr Stephen R Clark 


RESEARCH

I am a Lecturer in Immunopharmacology at the School of Pharmacy & Pharmaceutical Sciences, Cardiff University, where I run a laboratory focused on innate cellular immune defences against invading microorganisms.  

My interests include anti-microbial defences of neutrophils and the neutrophil extracellular traps (NETs) that they produce.  NETs are formed when activated neutrophils release large web-like structures of DNA decorated with granule proteins.  Formation of NETs is an important protective anti-microbial response to bacteria, fungi and viruses but occurs at the expense of tissue injury.  I am particular keen to understand how the formation of NETs is controlled and limited during many forms of neutrophil activation.

Member of the Critical Illness Research Group