Prof Gavin Wilkinson
Telephone:+44(0)29 206 87349
Extension:87349
Location:Tenovus Building, Heath Park, Cardiff University, Cardiff, CF14 4XN Wales, UK
Research Group
Research Areas
The molecular biology of cytomegalovirus and adenovirus.
Selected Publications
Tomasec, P., Braud, V.M., Rickards C., Powell, M.B., McSharry, B.P., Gadola, S., Curandola, V., Borysiewicz, L.K., McMichael, A.J. and Wilkinson, G.W.G. (2000). Human cytomegalovirus gpUL40 protects against natural killer cell attack. Science, 287. 5455-5458.
Wang, E.C.Y., McSharry, B., Retiere, C., Tomasec, P., Williams, S, Borysiewicz, LK, Braud, V.M., and Wilkinson, G.W.G. (2002). UL40-mediated NK evasion during productive infection with human cytomegalovirus. Proc. Natl. Acad. Sci. USA. 99, 7570-7575.
Dolan, A., Cunningham, C., Hector, R. D. Hassan-Walker, A.F., Lee, L., Addison, C., Dargan, D.J., McGeoch, D.J., Gatherer, D., Emery, V.C., Griffiths P.D., Sinzger, C., McSharry, B.P., Wilkinson G.W.G. and Davison A.J. (2004). Genetic content of wild type human cytomegalovirus. J. Gen Virol. 85, 1301-1312.
Tomasec, P., Wang, E.C.Y., Davison, A.J., Vojtesek, B., Armstrong, M., Griffin, C.A., McSharry, B.P., Morris, R.J., Llewellyn-Lacey, S., Rickards, C., Akio Nomoto, A., Sinzger,C. and Wilkinson. G.W.G. (2005) Down-regulation of NK Cell Activating Ligand CD155 by Human Cytomegalovirus UL141. Nature Immunol. 6, 181-188.
Wills, M.R., Ashiru, O., Reeves, M., Okecha, G., Trowsdale, J., Tomasec, P, Wilkinson, G.W.G., Sinclair, J., and Sissons, JPG. (2005). Human cytomegalovirus encodes an MHC class I-like molecule (UL142) that functions to inhibit Natural Killer (NK) cell lysis. J. Immunol. 175, 7457-7465.
Prod’homme, V., Griffin, C., Aicheler, R. J., Wang E.C.Y., McSharry. B.P., Rickards, C.R., Stanton, R.J., Borysiewicz L.K., López-Botet, M., Wilkinson, G. W. G., and Tomasec, P. (2007). The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1- NK Cells J. Immunol. 178, 4473-81.
Stanton, R.J., McSharry, B.P., Rickards, C.R., Wang, E.C.Y., Tomasec, P. and Wilkinson, G.W.G. (2007). Cytomegalovirus Destruction of Focal Adhesions Revealed in a High Throughput Western Blot Analysis of Cellular Protein Expression. J. Virol. 81, 7860-72.
Reeves, M, Davies, A., McSharry, B.P., Wilkinson, G.W.G. and Sinclair. J. (2007). Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death. Science 316, 1345-8.