Current development of IC ITC
New equilibrium equations are being added to the program. Equilibria can also be added in collaboration, but at the programmer's discretion. The programs icitc and prep4icitc are being rewritten and combined into one stand-alone application for analysis of isothermal titration calorimetry data.
Natural work flow
The work flow in ic itc is ordered around the natural sequence of data analysis steps as discussed in 10.1016/j.ymeth.2007.01.010. The core programme IC ITC (icitc.exe) or its successor I2CITC is used in combination with prep4icitc, where prep4icitc provides the graphical user interface for most aspects of data handling. Prep4icitc is used to generate the input files for ICITC and I2CITC in a user friendly way. Actual fitting then occurs using icitc.exe or i2citc_32.exe. Prep4icitc also facilitates post-fitting error analysis (Fig. 3).
|data preparation||data analysis||error evaluation|
Programmes constituting the IC ITC package
|ic_itc||core of the programme.||description|
|prep4icitc||Generates all input files for IC ITC, allows sequential titrations as described in the literature, runs post fitting error analysis. Prep4icitc is effectively the GUI for ICITC||guided data analysis|
How do I get my copy of IC ITC?
Request your copy of ICITC and I2CITC by filling in the registration form and sending a message to Niek Buurma (firstname.lastname@example.org) with subject line 'IC ITC request'. You will then receive a reply directing you to the download location. By default, you will be provided with the most recent stable beta version, in combination with information on which models can be considered stable and which interaction models are currently under development.
How do I use my copy of IC ITC?
When you start using ICITC and/or I2CITC, you may need some further instructions. Feel absolutely free to contact me to ask for further support. Requests for further support ae exactly what drives the development of the program. Manuals and user guide
Manuals are available in the form of a guided data analysis using example data and the FAQ. These documents are under construction and feedback (email@example.com) is greatly appreciated.