ORIGINAL PAPERS (REFEREED)

Scudiero, R., Verde, C., Carginale, V., Kille P., Capasso, C., di-Prisco, G and Parisi, E. (2000) Tissue-specific regulation of metallothionein and metallothionein mRNA accumulation in the Antarctic notothenioid, Notothenia coriiceps. Polar Biology 23, 17-23

Capasso C, Lees W E, Capasso A, Scudiero R, Carginale V, Kille P, Kay J & Parisi E (1999) Cathepsin D from the liver of the Antarctic icefish Chionodraco hamatus exhibits unusual activity and stability at high temperatures. Biochem. et Biophys. Acta 1431, 64-73.

Stürzenbaum, S. R., Morgan, A. J. and Kille, P. (1999) Characterisation and quantification of earthworm cyclophilins: identification of invariant and heavy metal responsive isoforms. Biochim. Biophys. Acta 1489, 467-473.

Galaxy Burgos, M., Winters, C., Morgan, A. J. and Kille, P. (1999) Molecular diagnosis of pollution impact on life-history parameters in earthworms. Pedobiologia. 43, 602-607.

Morgan, A. J., Stürzenbaum, S. R. and Kille, P. (1999) A short overview of molecular biomarker strategies with particular regard to recent developments in earthworm. Pedobiologia. 43, 574-584.

Morgan, A. J., Stürzenbaum, S. R., Winters, C. and Kille, P. (1999) Cellular and molecular aspects of metal sequestration and toxicity in earthworms. J. Invert. Reproduction and Development 36, 17-24.

Chapman, G., Kay, J. and Kille, P. (1999) Structural and functional analysis of the rat metallothionein III genomic locus. Biochim Biophys Acta 1445, 321-329.

Morris, C. A., Sampson, V., Nicolaus, B., Harwood, J. L. and Kille, P. (1999) Expression and characterisation of a metallothionein from the marine algae, Fucus vesiculosis. Biochem. J. 338, 558-560.

Stasio de, R., Borrelli, L., Kille, P. Parisi, E. and Filosa, S. (1999) Isolation, characterisation and molecular cloning of cathepsin D from lizard ovary: Changes in enzyme activity and mRNA expression throughout ovarian cycle. Mol. Reproduction and Development 52, 126-134.

Capasso, C., Lees, W. E., Capasso, A., Prisco, G., Kille P. and Kay, J. (1998) Enhanced catalytic efficiency and thermal stability of cathepsin D from an antarctic icefish. Biochim. Biophys Acta 1387, 457-461.

Carginale, V., Scudiero, R., Capasso, C., Capasso, A., Kille, P. Prisco, G, Di. And Parisi, E. (1998) Cadmium-induced differential accumulation of metallothionein isoforms in the Antarctic fish, which exhibits no basal metallothionein protein but high endogenous mRNA levels. Biochem. J. 332, 475-481.

Marino, F. I., Stürzenbaum, S. R., Kille, P. and Morgan, A. J. (1998). Cu-Cd interactions in earthworms maintained in laboratory microcosms: The examination of a putative copper paradox. Comp. Biochem. Physiol. C 120, 217-223.

Stürzenbaum, S. R., Kille, P. and Morgan, A. J. (1998). The identification, cloning and characterisation of earthworm metallothionein. Febs Letts. 431, 437-442.

Riggio, M., Capasso, A., Scudiero, R., Carginale, V., Prisco, G., Kille, P., Kay, J. and Parisi, E. (1998) Molecular cloning and sequence determination of a novel aspartic proteinase from antarctic fish. Biochim. Biophys. Acta 1387, 457-461.

Stürzenbaum, S. R., Kille, P. and Morgan, A. J. (1998) Translationally Controlled Tumor Protein (TCTP) in the Earthworms : Identification of a Heavy Metal Response. Biochim Biophys. Acta 1398, 294-304.

Stürzenbaum, S. R. Kille, P. and Morgan, A. J. (1998) Heavy Metal induced Molecular Responses in the Earthworm : Genetic Fingerprinting by Directed Differential Display. Applied Soil Ecology. 9, 495-500.

Scudiero, R., Riggio, M., Capasso, A., Carginale, V., Prisco, G., Kille, P. and Parisi, E. (1997) Difference in Hepatic Metallothionein Content in Red-Blooded and Haemoglobinless Antarctic Fishes. Biochem J. 322, 207 - 211

Santos, C. R. A., Power, D., Kille, P., Llewellyn, L., Ramsurn, V. P., Wigham, T. and Sweeney, G. E. (1996) Cloning and sequencing of a full length seabream (Sparus aurata) b -Actin cDNA. Comp. Biochem. Physiol 117, 185-189.

Olsson, P-E. and Kille, P. (1997) Functional comparison of the metal-regulated transcriptional control regions of metallothionein genes from cadmium tolerant and sensitive teleost species. Biochim. Biophys. Acta 1350, 325-334.

Olsson, P-E. and Kille, P. (1997) Cadmium sensitivity of three different fish species: Involvement of metallothionein. J. Aquatic Ecosystem Health in press.

Lambert, E., Kille, P. and Swaminathan, R. (1996) Cloning and sequencing a novel metallothionein I Isoform expressed in human reticulocytes. FEBS Lett. 389, 210-212.

Belloso, E, Hernandez. J., Giralt. M., Kille. P. and Hidalgo, J. (1996) Effect of stress on mouse and rat brain metallothionein I and III mRNA levels. Neuroendocrinology 64, 430-439

Kling, P, Erkell, L. J., Kille, P. and Olsson, P. E. (1996) Metallothionein induction in rainbow-trout gonadal cells during free-radical exposure. Marine Environmental Research 42, 33-36

Olsson, P-E., Kling, P., Erkell, L. J. and Kille, P (1995) Structural and functional analysis of the rainbow trout (Oncorhyncus mykiss) metallothionein-A gene. Eur. J. Biochem. 230, 344-349.

Kille, P., Kay, J. and Sweeney, G. E. (1995) Molecular biology and environmental induction of piscine metallothioneins. J. Marine Environmental Research. 39, 107-110.

Jones, J. L., Kille, P., Dancer, J. E. and Harwood, J. L. (1993) The cloning and overexpression of E. coli acyl carrier protein. Grasas y Aceitas 44, 116 - 117.

Kille, P., Kay, J. and Sweeney, G. E. (1993) Analysis of regulatory elements flanking metallothionein genes in Cd-tolerant fish (pike and stone loach). Biochim. Biophys. Acta. 1216, 55 - 64.

Edwards, W. D., Daniels, S. E., Page, R. A., Volpe, C. P., Kille, P., Sweeney, G. E. and Cryer, A. (1993) Cloning and sequencing of a full length cDNA encoding ovine lipoprotein lipase. Biochim. Biophys. Acta 1172, 167 - 170.

Kille, P., Lees, W E., Darke, B. M., Winge, D. R., Dameron, C. T., Stephens, P. E. and Kay, J. (1992) Sequestration of cadmium and copper by recombinant rainbow trout and human metallothioneins and by chimeric (mermaid and fishman) proteins with interchanged domains. J. Biol. Chem. 267, 8042 - 4049.

Kille, P., Kay, J., Leaver, M. and George, S. (1992) Induction of Piscine Metallothionein as a Primary Response to Heavy Metal Pollutants: Applicability of New Sensitive Molecular Probes. Aquat. Toxicol. 22, 279 - 286.

Kille, P., Winge, D. R., Harwood, J. L. and Kay, J. (1991) A plant metallothionein produced in E. coli. FEBS Lett. 295, 171 - 175.

Kille, P., Stephens, P. E. and Kay, J. (1991) Elucidation of cDNA sequences for MTs from rainbow trout, stone loach and pike liver using the Polymerase Chain Reaction. Biochim. Biophys. Acta 1084, 407 - 410.

Kille, P., Stephens, P. E., Cryer, A. and Kay, J. (1990) The expression of a synthetic rainbow trout gene in E. coli. Biochim. Biophys. Acta 1048, 178 - 186.

Gacesa, P., Caswell, R. C. and Kille, P. (1989) Bacterial alginases. Antibiot. Chemother. 42, 67-71

ORIGINAL PAPERS (In press)

Galaxy Burgos, M., Winters, C., Morgan, A. J. and Mile, P. (1999) Molecular diagnosis of pollution impact on life-history parameters in earthworms. Pedobiologia. In press.

Abd. Aziz, N. A., Molnar, L., Morgan, A. J. and Mile, P. (1999) A new stable neutral red staining biomarker for monitoring sublethal cytotoxicity in earthworms: Validation in semi-field experiments. Pedobiologia. In press.

Abd. Aziz, N. A., Morgan, A. J. and Kille, P. (1999) Metal resistance in earthworms: genetics adaptation or physiological acclimation? Pedobiologia. In press.

Morgan, A. 3., Sturzenbaum, S. R. and Kille, P. (1999) Life-cycle pararneters and molecular genetic responses to metal stress. Pedobiologia. In press.

Morgan, A. J., Sturzenbaum, S. R., and Winters, C. and Kille, P. (1999) Cellular and molecular aspects of metal sequestration and toxicity in earthworms. J. Invert. Reproduction and Development In press.


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