ADAPTATION TO INORGANIC
POLLUTANTS IN FISH
24/08/99
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Table of Contents
ADAPTATION TO
INORGANIC POLLUTANTS IN FISH
ESSSENTIAL
ELEMENTS
CLASSES OF
METALS
ESSENTIAL
METALS IMPACT IN BODY
METAL
IMBALANCE DISEASES
TOXIC METAL
IONS
NOT ALL HEAVY
METALS ARE EQUAL !!
SOURCES OF
HEAVY METAL POLLUTION
METAL FLOW IN
FISH
CONTROLLING
METAL FLOW IN FISH
MEASURING
OVERALL METAL EFFECT
WHY FISH ?
ROUTES OF ASSIMILATION
EXCLUSION THE
BAD COMES WITH THE GOOD - METAL UPTAKE
Ca
relationship with Cd uptake
Ca EFFECT ON
Cd UPTAKE IN PERFUSED GILLS OVERALL CD TOXICITY
?
Ca EFFECT ON
Cd UPTAKE OVERALL Cd TOXICITY ?
Zn UPTAKE
BLOCKED BY BLOCKING CHLORIDE CHANNELS
INTRACELLULAR
BINDING OF CD - METALLOTHIONEIN
METALLOTHIONEIN
STRUCTURE
TRANSCRIPTION
MEDIATED INDUCTION OF METALLOTHIONEIN
Zn PROTECTION
Zn
PROTECTION
EXCRETION
DIFFERENTIAL
SENSITIVITY OF FISH SPECIES
RT / SL / PI
Retention
Cadmium LC50
Distribution
in RT / SL/ PI
Metallothionein
Protein Sequences
Metallothionein
Genomic Locus Structure
Metallothionein
Promoter Structure
Control of
gene expression - Pike TATA
Control of
gene expression Zn better than Cd - Zn
protection
LOOK AT METAL
BOUND
Metal
Flow
Cd
DISTRIBUTION IN RAINBOW TROUT, STONE LOACH AND
PIKE
Differential
Metal Sensitivity, the answer !!
Page last updated October 1999 by Dr P.
Kille
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