Serine Proteases of E. coli



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Proteases are listed according to their celluar localisation and in alphabetical order. MWs of periplasmic and outer membrane proteases are given for the unprocessed precursor proteins. Clicking on the protein name will open the latest SwissProt file.


Proteases localised in the

Cytoplasm
Cytoplasmic membrane
Periplasm
Outer membrane




Cytoplasm

ATP-dependent Clp protease proteolytic subunit (clpP )
Peptidase familyS14 InterPro
FunctionHeat shock protein, chymotrypsin-like activity, major role in the degradation of misfolded proteins
StructurePDB
MW23186 Da
207 aa


Lon protease homolog (ycbZ )
Peptidase familyS16
FunctionLacks ATP ase domain of Lon
Structure 
MW65818 Da
586 aa

Protease Lon (lon )
Peptidase familyS16 InterPro
FunctionHeat shock protein, ATP-dependent Ser protease, broad substrate specificity
Structure 
MW87438 Da
784 aa

Alpha-aspartyl dipeptidase /Peptidase E (pepE )
Peptidase familySerine (according to MEROPS)
FunctionHydrolyses dipeptides containing n-terminal aspartate residues
Structure 
MW24570 Da
229 aa

Protease II (ptrB )
Peptidase familyS9A InterPro
FunctionCleaves after Lys and Arg residues
Structure 
MW79490 Da
686 aa



Cytoplasmic membrane

Protease DegS (degS )
Peptidase familyS2C InterPro
FunctionEssential serine protease, Cleaves RseA to induce sigma E cascade
StructurePDB
MW37581 Da
355 aa


GlpG (glpG )
Peptidase familyS54 InterPro
Function 
Structuretransmembrane domains: 6 (potential)
MW31307 Da
276 aa

Leader peptidase I (LepB )
Peptidase familyS26 InterPro
FunctionGeneral leader peptidase
StructurePDB

2 TM, periplasmic N-and C-termini

MW35960 Da
324 aa

Possible Ser protease SohB (sohB )
Peptidase familyS49 InterPro
FunctionSuppressor of degP(htrA) null mutation
Structure1 TM?
MW39366 Da
349 aa

Signal peptide peptidase/Protease IV (sppA )
Peptidase familyS49 InterPro
FunctionDegrades cleaved signal peptides
Structure3 TM?
MW67233 Da
618 aa



Periplasm

PBP-5, D-alanyl-D-alanine carboxypeptidase fraction A (dacA )
Peptidase familyS11InterPro
FunctionCell wall formation
Structure 
MW44444 Da
403 aa (1-29 signal pept.)

PBP-4, D-alanyl-D-alanine carboxypeptidase (dacB )
Peptidase familyS13InterPro
FunctionCell wall formation
Structure 
MW51798 Da
477 aa (1-20 signal pept.)

PBP-6, D-alanyl-D-alanine carboxypeptidase fraction C (dacC )
Peptidase familyS11InterPro
FunctionCell wall formation
Structure 
MW43609 Da
400 aa (1-27 signal pept.)

PBP-6B, D-alanyl-D-alanine carboxypeptidase (dacD )
Peptidase familyS11InterPro
FunctionCell wall formation
Structure 
MW43346 Da
388 aa (1-21 signal pept.)

Protease Do (degP/htrA )
Peptidase familyS2C InterPro
FunctionHeat shock protein, serine protease and chaperone ectivities, required at high temperature, virulence factor, involved in refolding and degradation of damaged proteins
StructurePDB
MW49439 Da
474 aa (1-26 signal pept.)


Protease DegQ (degQ )
Peptidase familyS2C InterPro
FunctionSerine protease
Structure 2 PDZ domains
MW47205 Da
455 aa (1-27 signal pept.)


PBP-7, D-alanyl-D-alanine-endopeptidase (pbpG or b2134 )
Peptidase familyS11InterPro
FunctionCell wall formation
Structure 
MW34245 Da
313 aa (1-28 signal pept.)

Tail-specific protease Prc/Tsp (tsp )
Peptidase familyS41 InterPro
FunctionDegrades proteins containing a 11 residue C-term. ssrA degradation tag
Structure1 PDZ domain
MW76663 Da
682 aa (1-22 signal pept.)


UmuD (umuD )
Peptidase familyS24 InterPro
Function 
Structure 
MW15063 Da
139 aa (1-24 signal pept.)


Putative protease YdgD (ydgD )
Peptidase familyS2B InterPro
Function 
Structure 
MW29277 Da
273 aa (1-21 signal pept.)




Outer membrane

OmpT/ProteaseVII (ompT )
Peptidase familyS18 InterPro
FunctionThe 3D structure questions that OmpT is a ser protease.
StructurePDB
MW35562 Da
317 aa (1-20 Signal peptide)