Metalloproteases of E. coli



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Proteases are listed according to their celluar localisation and in alphabetical order. MWs of periplasmic and outer membrane proteases are given for the unprocessed precursor proteins. Clicking on the protein name will open the latest SwissProt file.


Proteases localised in the

Cytoplasm
Cytoplasmic membrane
Periplasm
Outer membrane




Cytoplasm

Aminobenzoyl-glutamate utilization protein A (abgA )
Peptidase familyM40 InterPro
Function 
Structure 
MW46588 Da
436 aa


Leucine aminopeptidase LAP (ampA )
Peptidase familyM17 InterPro
Function 
Structure 
MW54879 Da
503 aa


Methionine aminopeptidase (ampM )
Peptidase familyM24A InterPro
FunctionRemoves the N-terminal methionine from nascent proteins
StructurePD B
MW29331 Da
264 aa


Xaa-Pro aminopeptidase/AmpP (pepP )
Peptidase familyM24B InterPro
FunctionReleases any N-terminal amino acid preceding proline, even from short peptides
StructurePDB
MW49684 Da
440 aa


Dipeptidyl carboxypeptidase (dcp )
Peptidase familyM3 InterPro
FunctionRemoves dipeptides from the c-termini of oligopeptides, broad specificity, does not hydrolyse bonds in which p1' is Pro, or both p1 and p1' are Gly
Structure 
MW77384 Da
680 aa


D-alanyl-D-alanine dipeptidase (ddpX/vanX )
Peptidase familyM45 InterPro
FunctionHydrolyses Ala-Ala
Structure 
MW21213 Da
193 aa

Putative frv operon protein FrvX (frvX )
Peptidase familyM42/Glutamyl aminopeptidase (Lactococcus)
FunctionUnclear, homolog of SgcX of E. coli
Structure 
MW38733 Da
356 aa

Gcp Glycoprotease (gcp/b3064 )
Peptidase familyM22 InterPro
Function 
Structure 
MW36024 Da
337 aa

Hydrogenase 1 maturation protease (hyaD )
Peptidase familyM52 InterPro
FunctionInvolved in maturation (C-terminal processing) of HyaB, the subunit of hydrogenase 1
Structure 
MW21546 Da
195 aa

Hydrogenase 2 maturation protease (hybD )
Peptidase familyM52 InterPro
FunctionInvolved in maturation (C-terminal processing) of HybB, the subunit of hydrogenase 2
Structure 
MW17751 Da
164 aa

Hydrogenase 3 maturation protease (hycI )
Peptidase familyM52 InterPro
FunctionInvolved in maturation (C-terminal processing) of HycE, the large subunit of hydrogenase 3
Structure 
MW16925 Da
155 aa

Isoaspartyl dipeptidase IadA (iadA )
Peptidase familyM38
FunctionHydrolyses l-isoaspartyl (l-beta-aspartyl) dipeptides, to degrade proteins damaged by l-isoaspartyl residue formation
Structure 
MW41084 Da
390 aa

Oligopeptidase A (prlC )
Peptidase familyM3 InterPro
Function 
Structure 
MW77167 Da
680 aa

Aminoacyl-histidine dipeptidase/Peptidase D (pepD )
Peptidase familyM25 InterPro
FunctionXaa-His dipeptidase, has specificity for the unusual dipeptide beta-alanyl-l-histidine.
Structure 
MW52784 Da
484 aa

X-Pro dipeptidase/Peptidase Q (pepQ )
Peptidase familyM24B InterPro
FunctionHydrolysis of Xaa-|-Pro dipeptides, but not on Pro-|-Pro
Structure 
MW50176 Da
443 aa

Aminotripeptidase/Peptidase T (pepT )
Peptidase familyM20A InterPro
FunctionHydrolyzes a tripeptides containing n-terminal Met, Leu, or Phe
Structure 
MW44923 Da
408 aa

Probable zinc protease PqqL (pqqL/b1494 )
Peptidase familyM16 InterPro
Function 
Structure 
MW104656 Da
931 aa

Putative sgc operon protein SgcX (sgcX )
Peptidase familyM42/Glutamyl aminopeptidase (Lactococcus)
FunctionUnclear, homolog of FrvX of E. coli
Structure 
MW41729 Da
383 aa

SprT Protein (sprT )
Peptidase familyZn MTpeptdseInterPro
Function 
Structure 
MW19348 Da
165 aa

Putative metalloprotease YcaL (ycaL )
Peptidase familyM48InterPro
FunctionHomolog of YggG of E. coli
Structure 
MW26740 Da
254 aa

Hypothetical protease YeaZ (yeaZ )
Peptidase familyM22InterPro
Function 
Structure 
MW25181 Da
231 aa

Hypothetical protein YgeY (ygeY )
Peptidase familyM20AInterPro
Function 
Structure 
MW44804 Da
403 aa

Putative metalloprotease YggG (yggG )
Peptidase familyM48InterPro
FunctionHomolog of YcaL of E. coli
Structure 
MW26842 Da
252 aa

Hypothetical protein YibP (yibG )
Peptidase familyM37InterPro
Function 
Structure 
MW46594 Da
419 aa



Cytoplasmic membrane

FtsH (ftsH/hflB )
Peptidase familyM41/AAA Protease InterPro
Functionessential ATP-dependent zinc metalloprotease, cleaves soluble and integral membrane proteins
Structure2 TM, cytoplasmic N-and C-termini
MW70708 Da
644 aa

Heat shock protein HtpX (htpX )
Peptidase familyM48 InterPro
Function 
Structure4 TM, cytoplasmic N-and C-termini
MW31923 Da
293 aa

YaeL (yaeL )
Peptidase familyM50B InterPro
Function 
Structure4 TM, PDZ domain
MW49071 Da
450 aa

YfbL (yfbL )
Peptidase familyM28A
Function 
Structure 1TM
MW35931 Da
323 aa



Periplasm

Alkaline phosphatase isozyme conversion protein IAP (iap or b2753 )
Peptidase familyM28C
Function 
Structure 
MW37920 Da
345 aa (1-24 signal pept.)


Protease III (ptrA )
Peptidase familyM16 InterPro
FunctionEndopeptidase, may have preference for small peptides
Structure 
MW107708 Da
962 aa (1-23 signal pept.)


Hypothetical protein YebA (yebA )
Peptidase familyM37 InterPro
Function 
Structure 
MW49057 Da
440 aa (1-34 signal pept.)


Protein YhjJ (yhjI )
Peptidase familyM16 InterPro
Function 
Structure 
MW55527 Da
498 aa (1-24 signal pept.)




Outer membrane

Lipoprotein NlpD (nlpD )
Peptidase familyM37 InterPro
Function 
Structure 
MW40149 Da
379 aa (1-25 Signal peptide)