Aspartic Proteases of E. coli



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Proteases are listed according to their celluar localisation and in alphabetical order. MWs of periplasmic and outer membrane proteases are given for the unprocessed precursor proteins. Clicking on the protein name will open the latest SwissProt file.


Aspartic proteases localised in the

Cytoplasmic membrane

Leader peptidase Lep4/Prepilin-like protein (hofD/hopD )
Peptidase familyA24 InterPro
FunctionLeader peptidase, cleaves type-4 fimbrial leader sequence
Structure6 TM, cytoplasmic N-and C-termini
MW24957 Da
225 aa

Lipoprotein signal peptidase (lspA )
Peptidase familyA8 InterPro
FunctionLeader peptidase, removes signal peptides from lipoproteins
Structure4 TM
MW18156 Da
164 aa

Leader peptidase PppA (pppA )
Peptidase familyA24 InterPro
FunctionLeader peptidase, removes signal peptides from lipoproteins
Structure6 TM?
MW29466 Da
269 aa