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ecce/ outer membrane proteins/ transport
Porins
Other Transport/Receptor Proteins



Porins

Maltoporin precursor (lamB )
functioninvolved in the transport of maltose, maltodextrines and trehalose
interaction 
receptorfor several bacteriophages including lambda and Tp1
regulationMalT dependent, inducer is maltotriose
 homotrimer
3d structurePDB
spans the membrane 18 times
MW49912; 446 aa


Outer membrane porin protein NmpC precursor (nmpC )
function 
interaction 
receptor 
regulation 
 in wild-type strains of e.coli K12 the nmpC open reading frame is interrupted by an IS5 insertion and generates a hybrid open reading frame that is not expressed
however in mutant strain CS348 the IS6 element has been deleted ane nmpC is expressed
MW40316; 344 aa


Outer membrane protein C precursor (ompC )
functionpassive diffusion pore for small molecular weight hydrophilic materials
receptorfor bacteriophage ???
interaction 
regulation 
 3d structurePDB
MW40368; 367 aa


Outer membrane protein F precursor (ompF )
functionpassive diffusion pore for small molecular weight hydrophilic materials
receptorfor bacteriophage T2
interaction 
regulation 
 homotrimer
3d structurePDB
spans the membrane 16 times
MW39333; 362 aa


Outer membrane protein G precursor (ompG )
function 
receptor 
interaction 
regulation 
 monomer
large channel
MW34913; 301 aa


Outer membrane pore protein E precursor (phoE )
functionpore for efficient uptake of inorganic phosphate, phosphorylated compounds and some negatively charged solutes
receptor 
interaction 
regulationinduced when cells are grown under phosphate limitation
 homotrimer
3d structurePDB
spans the membrane 16 times
MW38922; 351 aa


Nucleoside-specific channel-forming protein Tsx precursor (tsx )
functionsubstrate-specific channel for nucleosides and deoxynucleosides
receptorfor colicin K and bacteriophage T6
interaction 
regulation 
MW33589; 294 aa


Other Outer Membrane Tansport/Receptor Proteins

Vitamin B12 receptor precursor (btuB )
functionreceptor for cobalmin and bacteriophage Bf23, necesarry for the uptake of E colicins
interaction 
receptorfor cobalmin and bacteriophage Bf23
regulation 
MW68407; 614 aa


Colicin I receptor precursor (cirA )
functionnot yet known, postulated to participate in iron transport
interaction 
receptorfor colicins IA and IB
regulationinduction: by iron and by cAMP/cAMP-receptor protein complex
MW73895; 663 aa


Copper homeostasis protein CutF precursor; (LIPOPROTEIN NlpE) (cutF )
functioninvolved in copper homeostasis, could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes
interaction 
cofactors 
regulation 
 attached to the outer membrane by a lipid anchor
MW25844; 236 aa


Long-chain fatty acid transport protein precursor (fadL )
functioninvolved in translocation of long-chain fatty acids across the outer membrane
receptorfor bacteriophage T2
interaction 
regulationinduction by long-chain fatty acids, expression of fadL is under control of FadR repressor
MW48857; 448 aa


IronIII dicitrate transport protein FecA precursor (fecA )
function 
receptorfor ironIII dicitrate
interactionfor induction TonB and ExbB have to be active
regulation 
 monomer
3d structurePDB
spans the membrane 22 times
MW85321; 774 aa


Ferrienterobactin receptor precursor (fepA )
functioninvolved in the initial step in iron uptake by binding ferrienterobactin
interaction 
receptorsfor colicins B and D
regulation 
 monomer
3d structurePDB
spans the membrane 22 times
MW82107; 746 aa


Ferrichrome-iron receptor precursor (fhuA )
functionbinds the ferrichrome-iron ligand
interactionwith TonB
binding of bacteriophage T5 triggers the opening of a high conductance ion channel
receptorfor bacteriophages T5, T1, PHI80 and for colicin M
regulation 
 monomer
3d structurePDB
spans the membrane 22 times
MW82182; 747 aa


Outer membrane receptor for FeIII-coprogen, FeIII-ferrioxamine B and FeIII-rhodotorulic acid (fhuE )
functionrequired for the uptake of ironIII via coprogen, ferrioxamine B and rhodotorulic acid
interaction 
receptorfor ferric-rhodotorulic acid
regulationfor induction, the TonB and the ExbB protein have to be active
MW81232; 729 aa


Probable general secretion pathway protein D precursor (gspD )
functioninvolved in a general secretion pathway for the export of proteins
interaction 
cofactors 
regulation 
MW71146; 654 aa


GspH
functionputative general secretion pathway protein H
interaction 
regulation 
MW18565 Da; 169 aa


Protein transport protein HofQ precursor (hofQ )
function 
interaction 
cofactors 
regulation 
MW44716; 412 aa


Outer membrane protein A precursor (ompA )
functionrequired for the actions of colicins K and L and for the stabilization of mating aggregates in conjugation
receptorfor a number of T-even like phages
interaction 
regulation 
 monomer
3d structurePDB
spans the membrane 8 times
MW37201; 346 aa


Organic Solvents Tolerance Protein precursor (ostA )
functiondetermines n-hexane tolerance, involved in OM permeability
interaction 
regulation 
MW89671 Da; 784 aa


Outer membrane protein TolC precursor (tolC )
functionouter membrane component of several efflux pumps (Acr, Emr, Col, Hly). Involved in multiple drug, detergent and dye resistance. Also involved in extracellular secretion of virulence factors, toxins and colicins.
receptorPhage U3
interactionwith efflux pumps
regulation 
structure3d structurePDB
homotrimer
each monomer spans the membrane 4 times
has large helical periplasmic domains
MW54014; 495 aa


Putative polysaccharide export protein Wza precursor (wza )
functionmay be involved in polysaccharide transport
receptor 
interaction 
regulation 
MW41910 MW; 379 aa