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ecce/ proteins of the inner membrane/ sugar transport

Sugar Permeases
Symports for Sugars
PTS-System Components


Sugar Permeases:

L-arabinose transport system permease protein AraH (araH )
functionpart of a binding protein dependent ABC transport system for L-arabinose
interaction 
regulation 
topologytransmembrane domains: 10 (potential)

TMHMM gives 28-50 54-73 80-99 103-125 132-151 171-193 223-242 252-270 277-294 299-318
SP gives 30-50 54-74 80-100 105-125 130-150 172-192 221-241 250-270 277-297 298-318

mmssvstsgs gapkssfsfg riwdqygMLV VFAVLFIACA IFVPNFATFI
nmkGLGLAIS MSGMVACGML FCLasgdfdL SVASVIACAG VTTAVVINLt
esLWIGVAAG LLLGVLCGLV NGFVIaklki nALITTLATM QIVRGLAYII
Sdgkavgied esffalgyan WFGLPAPIWL TVACLIIFGL LLnkttfgrn 200
tlaiggneea arlagvpvvr tkIIIFVLSG LVSAIAGIIL ASrmtsgqpm
tSIGYELIVI SACVLGGVSL kggigkISYV VAGILILGTV ENAMnllnIS
PFAQYVVRGL ILLAAVIFdr ykqkakrtv

MW 34342 Da; 329 aa


L-fucose permease (fucP )
functiontransport of L-fucose into the cell
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 21-41 61-83 88-110 120-142 155-177 212-234 260-282 292-314 327-346 351-373 382-404 414-431
SP gives 25-45 56-76 96-115 119-139 167-187 207-227 266-286 296-316 327-347 353-373 382-402 414-434

mgntsiqtqs yravdkdagq srSYIIPFAL LCSLFFLWAV Annlndillp
qfqqaftltn FQAGLIQSAF YFGYFIIPIP AGILMkklsy kAGIITGLFL
YALGAALFWP aaeimnytLF LVGLFIIAAG LGCLETAANP FVtvlgpess
ghfrLNLAQT FNSFGAIIAV VFGQSLILsn vphqsqdvld kmspeqlsay 200
khslvlsvqt pYMIIVAIVL LVALLIMLTK FPALqsdnhs dakqgsfsas
lsrlarirhw rWAVLAQFCY VGAQTACWSY LIryaveeip gMTAGFAANY
LTGTMVCFFI Grftgtwlis rfaphkVLAA YALIAMALCL ISAFAGghvg
LIALTLCSAF MSIQYPTIFS LGIknlgqdt kYGSSFIVMT IIGGGIVTPV 400
MGFVsdaagn iptAELIPAL CFAVIFIFAr frsqtatn

MW 47544 Da; 438 aa


High-affinity gluconate transporter (gntP )
functionhigh-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides and some hexoses, but not glucose
interaction 
regulation 
topologytransmembrane domains: 13 (potential)

TMHMM gives 4-21 28-50 55-74 95-117 122-144 174-196 227-249 261-283 298-315 328-350 354-373 380-402 424-446
SP gives 1-21 29-49 55-75 104-124 127-147 176-196 225-245 261-281 295-315 330-350 352-372 375-395 427-447

mhvLNILWVV FGIGLMLVLN LkfkinsMVA LLVAALSVGM LAGMDLMSLL
htmkAGFGNT LGALAIIVVF GAVIgklmvd sgaahqiaht llarLGLRYV
QLSVIIIGLI FGLAMFYeva FIMLAPLVIV IAAEAKIPFL klaipavaaa
ttahslfppq pgpvalvnay gadMGMVYIY GVLVTIPSVI CAGLILpkfl 200
gnlerptpsf lkadqpvdmn nlpsfgVSIL VPLIPAIIMI STTIANIWLV
kdtpawevvn FIGSSPIAMF IAMVVAFVLF GTArghdmqw vmnafesAVK
SIAMVILIIG AGGVLkqtii dtgigdtIGM LMSHGNISPY IMAWLITVLI
rlaTGQGVVS AMTAAGIISA AILdpatgqL VGVNPALLVL ATAAGSNTLT 400
hindasfwlf kgyfdlsvkd tlkTWGLLEL VNSVVGLIIV LIISMVa

MW 47138 Da; 437 aa


Low-affinity gluconate transporter (gntU )
functionpart of the gluconate utilization system, low-affinity intake of gluconate
interaction 
regulation 
topologytransmembrane domains: 13 (potential)

TMHMM gives 4-21 28-47 57-79 104-126 146-168 175-197 228-250 262-284 299-321 328-350 354-373 386-408 423-445
SP gives 2-22 27-47 59-79 110-130 143-163 177-197 226-246 262-282 295-315 331-351 353-373 388-408 425-445

mttLTLVLTA VGSVLLLLFL VMkarmhAFL ALMVVSMGAG LFSGMPLdki
aatmekGMGG TLGFLAVVVA LGAMFGKILh etgavdqiav kmlksfghsr
ahyAIGLAGL VCALPLFFEV AIVLLIsvaf smarhtgtnl vkLVIPLFAG
VAAAAAFLVP GPAPMLLAsq mnadFGWMIL IGLCAAIPGM IIAGPLWgnf 200
isryvelhip ddisephlge gkmpsfgFSL SLILLPLVLV GLKTIAArfv
pegstayewf eFIGHPFTAI LVACLVAIYG LAMrqgmpkd kvmeicghAL
QPAGIILLVI GAGGVFKQVL VdsgvgpALG EALTGMGLPI AITCFVLAAA
vriIQGSATV ACLTAVGLVM PVIeqlnysg aqmaaLSICI AGGSIVVSHV 400
NDAGFWLFgk ftgateaetl ktWTMMETIL GTVGAIVGMI AFQLLs

MW 46416 Da; 446 aa


Maltose transport system permease protein MalF (malF )
functionpart of a binding protein dependent ABC transport system for maltose and maltodextrins
interactionforms a tight complex with MalG and MalK, interacts transiently with MalE
regulation 
topologytransmembrane domains: 8

TMHMM gives 17-36 40-57 70-92 284-306 319-341 370-392 413-435 484-506
SP gives 17-35 40-58 73-91 277-295 319-337 371-389 428-436 486-504

mdvikkkhww qsdalkWSVL GLLGLLVGYL VVLMYAqgeY LFAITTLILS
SAGLYIFanr kayawryvyp GMAGMGLFVL FPLVCTIAIA FTnysstnql
tferaqevll drswqagkty nfglypagde wqlalsdget gknylsdafk
fggeqklqlk ettaqpeger anlrvitqnr qalsditail pdgnkvmmss 200
lrqfsgtqpl ytldgdgtlt nnqsgvkyrp nnqigfyqsi tadgnwgdek
lspgytvttg wknftrvftd egiqkpflai fvwTVVFSLI TVFLTVAVGM
VLACLVqwea lrgkavyrVL LILPYAVPSF ISILIFKGLF Nqsfgeinmm
lsalfgvkpa wfsdpttarT MLIIVNTWLG YPYMMILCMG LLkaipddly 400
easamdgagp fqnffkITLP LLIKPLTPLM IASFAfnfnn fvliqlltng
gpdrlgtttp agytdllvny tyriafeggg gqdFGLAAAI ATLIFLLVGA
LAIVNLkatr mkfd

MW 57013 Da; 514 aa


Maltose transport system permease protein MalG (malG )
functionpart of a binding protein dependent ABC transport system for maltose and maltodextrins
interactionforms a tight complex with MalF and MalK, interacts transiently with MalE
regulation 
topologytransmembrane domains: 6

TMHMM gives 13-35 89-111 124-143 153-175 205-227 258-280
SP gives 19-39 82-102 124-144 151-171 205-225 260-280

mamvqpksqk arLFITHLLL LLFIAAIMFP LLMVVaislr qgnfatgsli
peqiswdhwk lalgfsveqa dgritpppfp vllwlwnsvk VAGISAIGIV
ALSTTCAYAF Armrfpgkat llkGMLIFQM FPAVLSLVAL YALfdrlgey
ipFIGLNTHG GVIFAYLGGI ALHVWtikgy fetidsslee aaaldgatpw 200
qafrLVLLPL SVPILAVVFI LSFIAAItev pvaslllrdv nsytlavgmq
qylnpqnYLW GDFAAAAVMS ALPITIVFLL aqrwlvnglt aggvkg

MW 32225 Da; 296 aa


Galactoside transport system permease protein MglC (mglC )
functionpart of a binding protein dependent ABC transport system for galactoside
interaction 
regulation 
topologytransmembrane domains: 8 (potential), TMHMM has 9

TMHMM gives 20-42 49-68 100-122 127-149 179-201 222-244 259-281 286-308 312-330
SP gives 17-37 53-73 107-127 181-201 227-247 257-277 279-299 306-326

msalnkksfl tylkeggiyV VLLVLLAIII FQDPTFLSLL NLsniltqSS
VRIIIALGVA GLIVTQGTdl sagrqvglaa vvaatllqsm dnankvfpeM
ATMPIALVIL IVCAIGAVIG LIngliiayl nvtpfittlg tmiivygins
lyydfvgasp isgfdsgfst faqgfvalgs frLSYITFYA LIAVAFVWVL 200
Wnktrfgkni faiggnpeaa kVSGVNVGLN LLMIYALSGV FYAFggmlea
grigsatnnL GFMYELDAIA ACVVGGVSFS GgvgtVIGVV TGVIIFTVIN
YGLTYIGVnp yWQYIIKGAI IIFAVALDSL kyarkk

MW 35550 Da; 336 aa


Ribose transport system permease protein RbsC (rbsC )
functionpart of a binding protein dependent transport system for ribose, probably responsible for translocation of the substrate across the membrane
interaction 
regulation 
topologytransmembrane domains: 6 (potential), TMHMM has 8

TMHMM gives 21-43 53-72 74-93 97-119 126-145 165-187 221-243 275-297
SP gives 23-43 57-77 126-145 169-190 221-240 295-316

mttqtvsgrr yftkawlmeq kSLIALLVLI AIVSTLSPNF FTInnlfnil
qqTSVNAIMA VGMTLVILTS GIdlsvgsll altgavaasi vgievnalva
vaaalalgaa igavtgviva kgrvqAFIAT LVMMLLLRGV TMVYTngspv
ntgftenadl fgwfgigrpL GVPTPVWIMG IVFLAAWYML hhtrlgryiy 200
alggneaatr lsginvnkik IIVYSLCGLL ASLAGIIEVA rlssaqptag
tgyeldaiaa vvlggtslag gkgrIVGTLI GALILGFLNN GLNLLGVssy
yqmivkavvi llavlvdnkk q

MW 33452 Da; 321 aa


Hexose phosphate transport protein (uhpT )
functiontransport system for sugar phosphate uptake
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 28-46 66-88 97-116 126-148 160-182 192-214 254-276 296-318 325-347 357-379 392-411 426-445
SP gives 27-45 67-89 97-116 121-140 160-187 191-210 250-274 295-318 328-344 351-379 392-411 426-446

mlaflnqvrk ptldlplevr rkmwfkpFMQ SYLVVFIGYL TMYLIrknfn
iaqndmisty glsmtqLGMI GLGFSITYGV GKTLVSYYad gkntkqFLPF
MLILSAICML GFSASMgsgs vslflMIAFY ALSGFFQSTG GSCSYSTItk
wtprrkrgtF LGFWNISHNL GGAGAAGVAL FGanylfdgh vIGMFIFPSI 200
IALIVGFIGL RYGSdspesy glgkaeelfg eeiseedket estdmtkwqi
fveYVLKNKV IWLLCFANIF LYVVrigidq wstvyafqel klskaVAIQG
FTLFEAGALV GTLLWGWLsd langrrGLVA CIALALIIAT LGVYQHAsne
yiylasLFAL GFLVFGPQLL IGVAAVGFVp kkaigaadgi kGTFAYLIGD 400
SFAKLGLGMI Adgtpvfglt gwagtFAALD IAAIGCICLM AIVAVmeerk
irrekkiqql tva

MW50606 Da; 436 aa


Xylose transport permease protein XylH (xylH )
functionpart of a binding protein dependent ABC transport system for D-xylose
interaction 
regulation 
topologytransmembrane domains: 10 (potential), SP has 11

TMHMM gives 24-46 61-80 85-107 111-133 140-162 177-196 216-235 240-259 331-353 368-385
SP gives 25-45 65-85 103-123 136-156 176-196 215-235 240-260 288-308 313-333 337-357 366-386

msksnpsevk lavptsggfs glkSLNLQVF VMIAAIIAIM LFFTWTtdga
ylsarnvsnL LRQTAITGIL AVGMVFVIIS aeidLSVGSM MGLLGGVAAI
CDVWLGWplp LTIIVTLVLG LLLGAWNGWW VAYrkvpsFI VTLAGMLAFR
GILIGITNGT TVsptsaams qigqsYLPAS TGFIIGALGL MAFVGWqwrg 200
rmrrqalglq spastAVVGR QALTAIIVLG AIWLLndyrG VPTPVLLLTL
LLLGGMFMAt rtafgrriya iggnleaarl sginvertkl avfainglmv
aiaglilssr lgagspsagn iaeldaiaac VIGGTSLAGG VGSVAGAVMG
AFImasldng msmmdvpTFW QYIVKGAILL LAVWMdsatk rrs

MW 41030 Da; 393 aa


Sugar Symporter

Arabinose-proton symport (araE )
functionuptake from arabinose across the membrane with the concomitant export of a proton
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 21-43 63-83 90-112 116-138 150-167 177-199 259-281 296-318 325-347 362-384 397-419 424-446
SP gives 23-43 63-83 92-110 120-138 149-167 177-197 259-278 299-318 328-348 362-382 396-415 424-443

mvtintesal tprslrdtrr MNMFVSVAAA VAGLLFGLDI GVIagalpfi
tdhfvltsrl qeWVVSSMML GAAIGALFNG WLSfrlgrkY SLMAGAILFV
LGSIGSAFAT SVemlIAARV VLGIAVGIAS YTAPLYLSem asenvrgkMI
SMYQLMVTLG IVLAFLSdta fsysgnwrAM LGVLALPAVL LIILVVFLPn 200
sprwlaekgr hieaeevlrm lrdtsekare elneireslk lkqggwalfk
inrnvrraVF LGMLLQAMQQ FTGMNIIMYY Aprifkmagf ttteqQMIAT
LVVGLTFMFA TFIAVFTVdk agrkPALKIG FSVMALGTLV LGYCLMQfdn
gtassglswl sVGMTMMCIA GYAMSAAPVV WILCseiqpl kcrdfgITCS 400
TTTNWVSNMI IGATFLTLLd sigAAGTFWL YTALNIAFVG ITFWLIpetk
nvtlehierk lmageklrni gv

MW 51684 Da; 472 aa


Sucrose transport protein (cscB )
functionproton symport transport system, essential role in sucrose metabolism
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 20-37 52-69 78-96 106-128 148-167 171-190 219-236 262-284 291-313 318-337 349-371 376-398
SP gives 14-36 50-70 78-102 106-128 148-166 170-190 221-245 258-280 289-308 313-332 345-364 378-397

malnipfrna yyrfassysF LFFISWSLWW SLYAIWLkgh lgltgtelgt
LYSVNQFTSI LFMMFYGIVq dklglkkpLI WCMSFILVLT GPFMIYvyep
llqsnFSVGL ILGALFFGLG YLAGCGLLds ftekmarnfh feygtarAWG
SFGYAIGAFF AGIFFSIsph INFWLVSLFG AVFMMINMrf kdkdhqciaa 200
daggvkkedf iavfkdrnFW VFVIFIVGTW SFYNIFdqql fpvfyaglfe
shdvgtrlyg yLNSFQVVLE ALCMAIIPFF Vnrvgpknal LIGVVIMALR
ILSCALFVNP WIIslvkLLH AIEVPLCVIS VFKYSVAnfd krlsstifLI
GFQIASSLGI VLLSTPTGIL FdhagYQTVF FAISGIVCLM LLFGIFFLsk 400
kreqivmetp vpsai

MW 46923Da; 415 aa


Galactose-proton symport (galP )
functionuptake of galactose with the concomitant export of a proton
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 13-35 55-77 84-103 108-130 142-159 169-191 252-274 289-311 318-340 350-372 385-407 417-436
SP gives 16-36 57-77 85-105 113-133 140-160 172-192 251-271 291-311 322-342 352-372 395-415 417-437

mpdakkqgrs nkAMTFFVCF LAALAGLLFG LDIGViagal pfiadefqit
shtqeWVVSS MMFGAAVGAV GSGWLSFklg rkkSLMIGAI LFVAGSLFSA
AAPnvevLIL SRVLLGLAVG VASYTAPLYL seiapekirg sMISMYQLMI
TIGILGAYLs dtafsytgaw rWMLGVIIIP AILLLIGVFF Lpdsprwfaa 200
krrfvdaerv llrlrdtsae akreldeire slqvkqsgwa lfkensnfrr
aVFLGVLLQV MQQFTGMNVI MYYApkifel agytntteqM WGTVIVGLTN
VLATFIAIGL VdrwgrkpTL TLGFLVMAAG MGVLGTMMHI gihspsaqyF
AIAMLLMFIV GFAMSAGPLI WVlcseiqpl kgrdFGITCS TATNWIANMI 400
VGATFLTmln tlgnanTFWV YAALNVLFIL LTLWLVpetk hvslehiern
lmkgrklrei gahd

MW 50982 Da; 464 aa


2-Keto-3-deoxygluconate permease (kdgT )
functiontransports degraded pectin products into cell, hydrogen coupled transport
interaction 
regulation 
topologytransmembrane domains: 10 (potential)

TMHMM gives 13-30 40-62 75-97 107-129 142-164 168-187 194-211 221-243 255-277 287-309
SP gives 10-30 42-62 73-93 95-115 139-159 163-183 199-219 224-244 254-274 290-310

mqikrsieki pgGMMLVPLF LGALCHTFSp gagkyfgsFT NGMITGTVPI
LAVWFFCMGA SIklsatgtv lrksGTLVVT KIAVAWVVAA IASRIIPehg
vevgffAGLS TLALVAAMDM TNGGLYASIm qqygtkeeag aFVLMSLESG
PLMTMIILGT AGIAsfephV FVGAVLPFLV GFALGNLdpe lreFFSKAVQ 200
TLIPFFAFAL Gntidltvia qTGLLGILLG VAVIIVTGIP LIIadkligg
gdgtAGIAAS SSAGAAVATP VLIAEMVpaf kpmapaATSL VATAVIVTSI
LVPILTSIWs rkvkaraaki eilgtvk

MW 33669 Da; 327 aa


Lactose permease (lacY )
functiontransport of beta-galctosides into cell with concomitant export of a proton
interaction 
regulation 
topologytransmembrane domains: 12, TMHMM has 11

TMHMM gives 13-35 45-67 76-98 103-125 145-164 168-187 222-239 261-283 304-326 346-368 380-402
SP gives 11-33 47-67 75-99 103-125 145-163 168-188 218-241 260-281 291-310 315-334 347-366 380-399

myylkntnfw mfGLFFFFYF FIMGAYFPFF PIWLHdinhi sksdTGIIFA
AISLFSLLFQ PLFGLLSdkl glrkyLLWII TGMLVMFAPF FIFIFGPLlq
ynILVGSIVG GIYLGFCFNA GAPAVeafie kvsrrsnfef grarMFGCVG
WALCASIVGI MFTInnqFVF WLGSGCALIL AVLLFFAktd apssatvana 200
vganhsafsl klalelfrqp kLWFLSLYVI GVSCTYDVFd qqfanfftsf
fatgeqgtrv FGYVTTMGEL LNASIMFFAP LIInriggkn alllagtims
vriIGSSFAT SALEVVILKT LHMFevpfll vgcfkyitsq fevrfSATIY
LVCFCFFKQL AMIFMSVLag nmyesigfqG AYLVLGLVAL GFTLISVFTL 400
SGpgplsllr rqvneva

MW 46503 Da; 417 aa


Melibiose carrier protein (melB )
functionmelibiose transport, capable of using hydrogen, sodium and lithium cations as coupling cations for cotransport depending on the particular sugar transported
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 5-27 32-54 74-96 106-128 141-163 173-195 232-254 264-286 293-315 320-342 374-396 406-428
SP gives 16-36 39-59 77-97 105-125 150-170 183-203 232-252 266-286 296-316 325-345 378-398 407-427

mttkLSYGFG AFGKDFAIGI VYMYLMYyyt dVVGLSVGLV GTLFLVARIW
DAINdpimgw ivnatrsrwg kfkpWILIGT LANSVILFLL FSAHLFegtt
qivfvCVTYI LWGMTYTIMD IPFWSLVPti tldkrereqL VPYPRFFASL
AGFVTAGVTL PFVnyvgggd rgFGFQMFTL VLIAFFIVST IITLrnvhev 200
fssdnqpsae gshltlkaiv aliykndqls cLLGMALAYN VASNIITGFA
IYYFsyvigd adlFPYYLSY AGAANLVTLV FFprlvksls rrILWAGASI
LPVLSCGVLL LMALMsyhnV VLIVIAGILL NVGTALFWVL QVimvadivd
ygeyklhvrc esiaysvqtm vvkGGSAFAA FFIAVVLGMI GYVPNVeqst 400
qallgMQFIM IALPTLFFMV TLILYFrfyr lngdtlrriq ihlldkyrkv
ppepvhadip vgavsdvka

MW 52217 Da; 469 aa


L-rhamnose-proton symport (rhaT )
functionuptake of L-rhamnose with concomitant export of a proton, can also transport L-mannose and L-xylose, but at reduced rates
interaction 
regulation 
topologytransmembrane domains: 10 (potential)

TMHMM gives 4-26 38-60 70-92 99-121 136-155 175-192 212-234 254-276 291-310 323-342
SP gives 6-26 37-57 62-82 97-117 131-152 175-195 209-229 255-275 290-310 322-342

msnAITMGIF WHLIGAASAA CFYAPFkkvk kwswetmWSV GGIVSWIILP
WAISALLLpn fwayyssfsL STRLPVFLFG AMWGIGNINY GLtmrylgMS
MGIGIAIGIT LIVGTLMTPI Ingnfdvlis teggrMTLLG VLVALIGVGI
VTRAGqlker kmgikaeefn lkkgLVLAVM CGIFSAGMSF AMnaakpmhe 200
aaaalgvdpl yVALPSYVVI MGGGAIINLG FCFIrlakvk dlslkadfsl
aksLIIHNVL LSTLGGLMWY LQFFFYawgh aripaqydyi SWMLHMSFYV
LCGGIVGLVL kewnnagrrp vtVLSLGCVV IIVAANIVGI GMan

MW 37319 Da; 344 aa


Glucuronide carrier protein (uidB )
function 
interaction 
regulation 
topologytransmembrane domains: 12 (potential), SP has 11

TMHMM gives 12-34 38-60 80-102 112-134 147-169 179-201 230-252 262-284 297-316 321-343 373-392 407-429
SP gives 22-42 44-64 80-100 109-129 147-167 181-201 229-249 264-284 309-329 373-393 409-429

mnqqlswrti VGYSLGDVAN NFAFAMGALF LLSYytdVAG VGAAAAGTML
LLVRVFDAFA dvfagrvvds vntrwgkfrp FLLFGTAPLM IFSVLVFWVL
TdwshgskVV YAYLTYMGLG LCYSLVNIPY GSLAtamtqq pqsrarLGAA
RGIAASLTFV CLAFLIGpsi knsspeemVS VYHFWTIVLA IAGMVLYFIC 200
Fkstrenvvr ivaqpslnis lqtlkrnrpL FMLCIGALCV LISTFAVSAS
SLfyvryvln dTGLFTVLVL VQNLVGTVAS APLVpgmvar igkkntFLIG
ALLGTCGYLL FFWVSVwslp VALVALAIAS IGQGVTMTVM WALeadtvey
geyltgvrie gltyslfsft rkCGQAIGGS IPAFILGLSG YIanqvqtpe 400
vimgirTSIA LVPCGFMLLA FVIIWFYPLt dkkfkeivve idnrkkvqqq
lisditn

MW 49908 Da; 457 aa


Xylose-proton symport (xylE )
functionuptake of D-xylose with the concomitant export of a proton
interaction 
regulationinsensitive to cold osmotic shock. induction:xylose
topologytransmembrane domains: 12 (potential)

TMHMM gives 13-35 55-77 90-109 129-151 164-186 201-220 271-293 313-333 346-368 373-395 408-427 442-464
SP gives 12-32 57-77 91-111 135-155 167-187 202-222 274-294 314-334 344-364 371-391 409-429 445-465

mntqynssYI FSITLVATLG GLLFGYdtav isgtveslnt vfvapqnlse
saanSLLGFC VASALIGCII GGALGGYcsn rfgrrdslkI AAVLFFISGV
GSAWPELGFt sinpdntvpv ylagyvpeFV IYRIIGGIGV GLASMLSPMY
Iaelapahir gklVSFNQFA IIFGQLLVYC VNYFIArsgd aswlntdgwr 200
YMFASECIPA LLFLMLLYTV pesprwlmsr gkqeqaegil rkimgntlat
qavqeikhsl dhgrktggrL LMFGVGVIVI GVMLSIFQQF VGInvvlyya
pevfktlgas tdIALLQTII VGVINLTFTV LAImtvdkfg rkplqIIGAL
GMAIGMFSLG TAFYTQApgi vaLLSMLFYV AAFAMSWGPV CWVLLseifp 400
nairgkaLAI AVAAQWLANY FVSWTFpmmd knswlvahfh nGFSYWIYGC
MGVLAALFMW KFVpetkgkt leelealwep etkktqqtat l

MW 53608 Da; 491 aa



PTS System Components

PTS system, N-acetylgalactosamine-specific IIC component 1 (agaC )
function 
interaction 
regulation 
topologycontains EIIC domain
transmembrane domains: 7 (potential), TMHMM has 6

TMHMM gives 4-21 28-50 96-118 139-161 176-198 210-232
SP gives 11-31 34-54 67-87 95-115 142-162 178-198 211-231

mheITLLQGL SLAALVFVLG IdfwleaLFL FRPIIVCTLT GAILGDIQTG
litggltela FAGLTPAGGV QPPNPIMAGL MTTVIAWstg vdaktAIGLG
LPFSLLMQYV ILFFYSAFsl fmtkadkcak eadtaafsRL NWTTMLIVAS
AYAVIAFLCT Ylaqgamqal vkampAWLTH GFEVAGGILP AVGFGLLLrv 200
mfkaqyipyL IAGFLFVCYI QVSNLLPVAV LGagfavyef fnaksrqqaq
pqpvasknee edysngi

MW 28645Da; 267 aa


PTS system, N-acetylgalactosamine-specific IID component (agaD )
function 
interaction 
regulation 
topologycontains EIID domain
transmembrane domains: 6 (potential), TMHMM has 5

TMHMM gives 98-120 135-157 177-199 219-236 243-262
SP gives 61-81 98-118 131-151 179-199 215-235 243-263

mgseiskkdi trlgfrssll qasfnyermq aggftwamlp ilkkiykddk
pglsaamkdn leFINTHPNL VGFLMGLLIS meekgenrdt ikglkvaLFG
PIAGIGDAIF WFTLLPIMAG icssfasqgn llgpILFFAV YLLIFFLRVG
WTHVGYsvgv kaidkvrens qmiarsATIL GITVIGGLIA SYVHINVVTs 200
faidnthsva lqqdffdkVF PNILPMAYTL LMYYFLrvkk ahPVLLIGVT
FVLSIVCSAF GIl

MW 29001 Da; 263 aa


PTS system, N-acetylgalactosamine-specific IIC component 2 (agaW )
function 
interaction 
regulation 
topologycontains EIIC domain
transmembrane domains: 4 (potential), TMHMM has 3

TMHMM gives 5-27 34-56 94-116
SP gives 3-23 33-53 66-86 94-114

meisLLQAFA LGIIAFIAGL DMFNGLThmh rpvVLGPLVG LVLGDLHTGI
LTGGTLeLVW MGLAPLAGAQ PPNVIIGTIV GTAFaittgv kpdVAVGVAV
PFAVAVQMGI TFLFSVmsgv msrcdlatnp rri

MW 13721 Da; 133 aa


PTS system, arbutin-, cellobiose-, and salicin-specific IIABC component (ascF )
function 
interaction 
regulation 
topologycontains EIIA; EIIB; EIIC
transmembrane domains: 8 (potential), SP has 10

TMHMM gives 104-126 146-168 175-197 212-234 255-277 282-304 389-411 434-456
SP gives 102-122 146-166 177-197 207-227 254-274 285-305 330-350 363-383 389-409 433-453

maknyaalar sviaalggvd nisavthcmt rlrfvikdda lidsptlkti
pgvlgvvrsd nqcqviignt vsqafqevvs llpgdmqpaq pvgkpkltlr
rigAGILDAL IGTMSPLIPA IIGGSMVkll amilemsgvl tkgspTLTIL
NVIGDGAFFF LPLMVAHLpr ikfktnMSLA IAIAGVLVHP SFIELMAkaa 200
qgehvefali pVTAVKYTYT VIPALVMTWC LSYIerwvds itpavtknfl
kpMLIVLIAA PLAILLIGPI GIWIGSAisa LVYTIHGYLG WLSVAIMGAL
WPLLvmtgmh rvftptiiqt iaetgkegmv mpseiganls lggsslavaw
ktknpelrqt alaaaasaim agisepalyg vairlkrpLI ASLISGFICG 400
AVAGMAGLAS Hsmaapglft svqffdpanp msIVWVFAVM ALAVVLSFIL
TLLLGFedip veeaaaqark yqsvqptvak evsln

MW 51229 Da; 485 aa


PTS sytem, beta-glucosides-specific IIABC component (bglF )
functionacts as kinase and phosphatase on bglG
interaction 
regulation 
topologycontains EIIA; EIIB; EIIC
transmembrane domains: 10 (potential), SP has 14

TMHMM gives 100-119 139-161 168-190 205-227 234-256 260-282 287-309 324-346 381-400 426-448
SP gives 59-79 100-120 141-161 167-187 203-223 245-265 285-305 325-345 355-375 381-401 404-424 432-452 490-510 526-546

mtelarkiva gvggadnivs lmhcatrlrf klkdeskaqa evlkktpgii
mvvesggqfq vvignhvadv flavnsvagl dekaqqapen ddkgnllnrF
VYVISGIFTP LIGLMAATGi lkgmlalalt fqwtteqsGT YLILFSASDA
LFWFFPIILG Ytagkrfggn pFTAMVIGGA LVHPLILTAF engqkadalg 200
ldFLGIPVTL LNYSSSVIPI IFSAWLCsil errLNAWLPS AIKNFFTPLL
CLMVITpvtF LLVGPLSTWI SELIAAGYLW LYqavpAFAG AVMGGFWQIF
VMFGLHWGLv plcinnftvl gydTMIPLLM PAIMAQVGAA LGVFLCerda
qkkvvagsaa ltslfgitep avygvnlprk YPFVIACISG ALGATIIGYA 400
qtkvysfglp siftfmqtip stgidFTVWA SVIGGVIAIG CAFVGTVMLh
fitakrqpaq gapqektpev itppeqggic spmtgeivpl ihvadttfas
gllgkgiail psvgevrspv agriaslfat lhaigiesdd gveilihvgi
dtvkldgkff sahvnvgdkv ntgdrlisfd ipaireagfd lttpvlisns 600
ddftdvlphg taqisagepl lsiir

MW 66482Da; 625 aa


PTS system, cellobiose-specific IIC component (celB )
functioncontains EIIC
interaction 
regulation 
topologytransmembrane domains: 10 (potential)

TMHMM gives 31-53 85-107 114-133 143-165 186-208 232-254 298-320 345-364 371-393 408-430
SP gives 35-55 86-106 114-134 147-167 187-207 229-249 300-320 344-364 367-387 409-429

msnviaslek vllpfavkig kqphvnaikn gFIRLMPLTL AGAMFVLINN
VFLsfgegsf fyslgirlda stietlnglk giggnVYNGT LGIMSLMAPF
FIGMALAeer kvdALAAGLL SVAAFMTVTP YSVgeayavg anWLGGANII
SGIIIGLVVA EMFTFivrrn wviklpdsvp asvsrSFSAL IPGFIILSVM 200
GIIAWALNTW gtnfhqiimd tistplaslg sVVGWAYVIF VPLLWFFGIH
GALALtaldn gimtpwalen iatyqqygsv eaalaagktf hiwakpmldS
FIFLGGSGAT LGLILAIFIA srradyrqva klalpsgifq inepILFGLP
IIMNPVMFIP FVLVqpilaa ITLAAYYMGI IPPVTNIAPW TMptglgaff 400
ntngsvaALL VALFNLGIAT LIYLPFVVVA nkaqnaidke eseedianal
kf

MW 48332 Da; 452 aa


PTS system, mannitol (cryptic)-specific IIBC component (cmtA )
function 
interaction 
regulation 
topologycontains EIIB andEIIC domain
transmembrane domains: 8, SP has 6

TMHMM gives 21-43 53-75 82-104 136-158 214-236 246-264 271-293 313-335
SP gives 26-45 52-70 136-155 167-185 274-294 317-336

menksarakv qafggfltaM VIPNIGAFIA WGFITALFIP TGWLpnehfa
kiVGPMITYL LPVMIGSTGG HLVGGkrgav mGGIGTIGVI VGAEIPMFLG
SMIMgplggl vikyvdkale kripagfemv innfsLGIAG MLLCLLGFEV
IGPAVLIAnt fvkeciealv hagylpllsv inepakvlfl nnaidqgvyy 200
plgmqqasvn gksIFFMVAS NPGPGLGLLL AFTLFGkgms krsapGAMII
HFLGGIHELY FPYVLMkplt IIAMIAGGMS GTWMFNLLDG GLVagpspgs
ifaylaltpk gsFLATIAGV TVGTLVSFAI TSLILkmekt vetesedefa
qsanavkamk qegafslsrv kriafvcdag mgssamgatt frkrlekagl 400
aievkhyaie nvpadadivv thaslegrvk rvtdkplili nnyigdpkld
tlfnqltaeh kh (potential)

MW 48971 Da; 462 aa


PTS system, fructose-specific IIBC component (fruA )
function 
interaction 
regulation 
topologycontains two EIIB domains and EIIC
transmembrane domains: 9, SP has 11

TMHMM gives 237-259 272-294 304-326 346-368 378-400 413-435 465-482 489-509 529-551
SP gives 106-126 156-176 236-256 274-294 304-324 349-369 382-402 430-450 463-483 489-509 518-538

mktlliidan lgqaraymak tllgaaarka kleiidnpnd aemaivlgds
ipndsalngk nvwlgdisra vahpelflse akghakpyta pvaatapvaa
sgpkrvvavt acptgvahtf maaeaietea kkrgwwvkve trgsvgagna
itpeevaaad lvivaadiev dlakfagkpm yrtstglalk ktaqeldkav 200
aeatpyepag kaqtattesk kesagayrhl ltgvsyMLPM VVAGGLCIAL
SFAFGIEAFk epgtlaaalm qIGGGSAFAL MVPVLAGYIA FSIAdrpglt
pglIGGMLAV STGSGFIGGI IAGFLAgyia klistqlklp qsmeaLKPIL
IIPLISSLVV GLAMIYLIgk pvagileGLT HWLQTMGTAN AVLLGAILGG 400
mmctdmggpv nkAAYAFGVG LLSTQTYGPM AAIMAagmvp plamglatmv
arrkfdkaqq eggkAALVLG LCFISEGAIP FAardpmrVL PCCIVGGALT
GAISMAIGAk lmaphgglfv llipgaitPV LGYLVAIIAG TLVAGLAYAF
Lkrpevdava kaa (potential)

MW 57519 Da; 563 aa


PTS sytsem, fructose-like-1 IIBC component (frvB )
function 
interaction 
regulation 
topologycontains EIIB and EIIC domain
transmembrane domains: 9 (potential), SP has 11

TMHMM gives 141-163 176-198 226-248 261-283 315-337 344-366 381-403 410-432 447-469
SP gives 9-29 134-154 182-202 206-226 229-249 266-286 305-325 346-366 382-402 404-424 444-464

messlriv aitncpagia htymvaeale qkarslghti kvetqgssgv
enrlsseeia aadyvilatg rglsgddrar fagkkvyeia isqalknidq
ifselptnsq lfaadsgvkl gkqevqsgsv mshlmagvsa ALPFVIGGGI
LVALANMLVQ FGLpytdmsk gapsfTWVVE SIGYLGFTFM IPIMGAYIas 198
siadkpafap aflvcyland kallgTQSGA GFLGAVVLGL AIGYFVFWfr
kvrlgkalqp LLGSMLIPFV TLLVFGVLTY YVIgpvmsdl mggllhflnt
ippsmkfaaa flvgAMLAFD MGGPINKTAW FFCFSLLekh iydWYAIVGV
VALMPPVAAG LATFIApklf trqekeaass AIVVGATVAT EPAIPYALAA 398
PLPmitantL AGGITGVLVI AFGIKRLAPG LGifdpligl mspvgsFYLV
LAIGLALNIS FIIVLKGLWl rrkakaaqqe lvheh

MW 51120 Da; 483 aa


PTS system, fructose-like-2 IIC component (frwC )
function 
interaction 
regulation 
topologycontains EIIC domain
transmembrane domains: 8 (potential), SP has 9

TMHMM gives 21-40 60-82 95-117 132-154 175-194 214-236 283-305 315-334
SP gives 19-39 60-80 99-119 135-155 176-196 216-236 251-271 290-310 314-334

mnelvqilkn trqhlmtgvs HMIPFVVSGG ILLAVSVMLY gkgavpdava
dpnlkklfdI GVAGLTLMVP FLAAYIGYSI AErsalapca igawVGNSFG
AGFFGALIAG IIGGIVVhyl kkipvhkvlr sVMPIFIIPI VGTLITAGIM
MWGLgepvga ltnsltqwlq gmqqGSIVML AVIMGLMLAF DMGGpvnkva 200
yafmlicvaq gvyTVVAIAA VGICIPPLGM GLATLIgrkn fsaeeretgk
aalvmgcvgv tegaipfaaa dplrvipsim vgSVCGAVTA ALVGAQCYAG
WGGLIvlpvv egklGYIAAV AVGAVVTAVC VNVLkslark ngsstdeked
dldldfein

MW 37086 Da; 359 aa


PTS system, galactitol-specific IIC component (gatC )
function 
interaction 
regulation 
topologycontains a EIIC domain
transmembrane domains: 11 (potential), SP has 10

TMHMM gives 4-26 39-58 91-113 134-156 176-198 218-240 300-322 329-348 353-372 385-407 417-435
SP gives 9-29 41-61 92-112 138-158 218-238 305-325 329-349 357-377 392-412 415-435

mfsevmrYIL DLGPTVMLPI VIIIFSkilg mkagdcfkAG LHIGIGFVGI
GLVIGLMLds igpaakamae nfdlnlhvvd vgwpgsspmt WASQIALVAI
PIAILVNVAM LLTrmtrvvn vdiwniwhmt ftgALLHLAT GSWMIGMAGV
VIHAAFVYkl gdwfardtrn ffeleGIAIP HGTSAYMGPI AVLVDAIIek 200
ipgvnrikfs addiqrkFGP FGEPVTVGFV MGLIIGILAG ydvkgvlqla
vktaavmllm prvikpimdg ltpiakqars rlqakfggqe fligldpalL
LGHTAVVSAS LIFIPLTILI AVcvpgnqVL PFGDLATIGF FVAMAVAVhr
gnlfrTLISG VIIMSITLWI ATQTIGLhtq laanAGALKA GGMVASMDQG 400
GSPITWLliq vfspqnIPGF IIIGAIYLTG IFMTWrrarg fikqekvvla
e

MW 48365 Da; 451 aa


PTS system, arbutin-like IIC component (glvC )
function 
interaction 
regulation 
topologycontains EIIC domain
transmembrane domains: 9 (potential)

TMHMM gives 10-32 91-113 128-150 162-184 199-221 234-256 276-298 305-323 338-360
SP gives 12-32 60-80 87-107 130-150 174-194 225-245 277-297 307-327 329-349

mlsqiqrFGG AMFTPVLLFP FAGIVVGLAI LLqnpmfvge sltdpnslfa
qivhiieegg wtvfrnmpli favglpigla kqaqgracLA VMVSFLTWNY
FINAMGMTWG SYFgvdftqd avagsgLTMM AGIKTLDTSI IGAIIISGIV
talhnrlfdk kLPVFLGIFQ GTSYVVIIAF LVMIpcawlt llgwpkvqMG 200
IESLQAFLRS AGALGVWVYT FLeriliptg lhhFIYGQFI FGPAAVEGGI
QMYWaqhlqe fslsaeplks lfpeggFALH GNSKIFGAVG ISLAMYFTaa
penrVKVAGL LIPATLTAML VGItepleft flfispLLFA VHAVLAASMS
TVMYLFGVVG nmggglid

MW 39692 Da; 368 aa


HrsA protein (hrsA )
functioninvolved in thermoinduction of OmpC
contains EIIA; EIIB; EIIC
interaction 
regulation 
topologytransmembrane domains: 11 (potential)

TMHMM gives 316-338 357-379 389-411 431-453 463-485 498-520 551-568 575-597 617-639
SP gives 183-203 314-334 359-379 391-411 434-454 475-495 501-521 552-572 574-594 600-620 621-641

mvlfyrahwr dykndqvrim mnlttlthrd alclnarfts reeaihaltq
rlaalgkiss teqfleevyr reslgptalg eglavphgkt aavkeaafav
atlseplqwe gvdgpeavdl vvllaippne agtthmqllt alttrladde
irariqsatt pdellsaldd kggtqpsasf snaptivcvt acpagiahty 200
maaeylekag rklgvnvyve kqgangiegr ltadqlnsat acifaaevai
keserfngip alsvpvaepi rhaealiqqa ltlkrsdetr tvqqdtqpvk
svktelkqal lsgisFAVPL IVAGGTVLAV AVLLSQIFgl qdlfneensw
lwmyrkLGGG LLGILMVPVL AAYTAYSLAd kpalapgFAA GLAANMIGSG 400
FLGAVVGGLI Agylmrwvkn hlrlsskfng FLTFYLYPVL GTLGAGSLML
FVVgepvawi nnSLTAWLNG LSGSNALLLG AILGFmcsfd lggpvnkAAY
AFCLGAMANG VYGPYAIFAS vkmvsaftvt astmlaprlf kefeietgks
TWLLGLAGIT EGAIPMAIed plrvIGSFVL GSMVTGAIVG AMNIGLStpg 600
agifslfllh dngaggVMAA IGWFGAALVG AAISTAILLm wrrhavkhgn
yltdgvmp

MW 69667 Da; 658 aa


PTS system, maltose-and glucose-specific IIABC component (malX )
functionpossibly glucose and maltose transporter, however, these sugars appear not to be the natural substrates of this system
contains EIIA; EIIB; EIIC
interaction 
regulation 
topologytransmembrane domains: 8, SP has 12

TMHMM gives 21-43 69-88 95-117 139-161 182-204 325-347 352-374 397-419
SP gives 22-42 47-67 69-89 96-116 138-158 189-209 227-247 289-309 321-341 343-363 369-389 399-419

mtaktapkvt lweffqqlgk TFMLPVALLS FCGIMLGIGS SLSshdvitl
ipvlgnpvlq aiftwmskIG SFAFSFLPVM FCIAIPLGLa renkGVAAFA
GFIGYAVMNL AVNFWLTnkg ilpttdaavl kanniqsiLG IQSIDTGILG
AVIAGIIVWM Lherfhnirl pdalaffggt rFVPIISSLV MGLVGLVIPL 200
VWPIFamgis glghminsag dfgpmlfgtg erlllpfglh hilvalirft
daggtqevcg qtvsgaltif qaqlscptth gfsesatrfl sqgkmpaflg
glpgaalamy hcarpenrhk ikgLLISGLI ACVVGGTTEP LEFLFLFVap
vLYVIHALLT GLGFTVMSVL GVTIgntdgn iidfvvfgil hglstkWYMV 400
PVVAAIWFVV YYVIFRFAIt rfnlktpgrd sevassieka vagapgksgy
nvpailealg gadnivsldn citrlrlsvk dmslvnvqal kdnraigvvq
lnqhnlqvvi gpqvqsvkde maglmhtvqa (potential)

MW 56627 Da; 530 aa


PTS system, mannitol-specific IIABC component (manY )
function 
interaction 
regulation 
topologycontains EIIC domain
transmembrane domains: 6 (potential)
MW 000 Da; 266 aa


PTS system, mannose-specific IID component (manZ )
function 
interaction 
regulation 
topologycontains EIID domain
transmembrane domains: 1 (potential)
MW 000 Da; 286 aa


PTS system, mannitol-specific IIABC component (mtlA )
function 
interaction 
regulation 
topologycontains EIIA; EIIB; EIIC
homodimer
transmembrane domains: 6 (potential)
MW 000 Da; 637 aa


PTS system, N-acetylglucosamine-specific IIABC component (nagE )
function
interaction 
regulation 
topologycontains EIIA; EIIB; EIIC
transmembrane domains: 12 (potential)
MW 000 Da; 648 aa


PTS system , glucose-specific IIBC component (ptsG )
function 
interaction 
regulation 
topologycontains EIIB; EIIC
3-d structure
transmembrane domains: 11 (potential)
MW 000 Da; 477 aa


putative phosphotransferase enzyme IIC component SgcC (sgcC )
function 
interaction 
regulation 
topologytransmembrane domains: 11 (potential), SP has 12

TMHMM gives 5-27 32-54 87-109 130-152 172-194 214-236 246-268 288-310 325-344 353-375 408-430
SP gives 5-25 35-55 88-108 134-154 173-193 215-235 236-256 302-322 325-345 354-374 385-405 410-430

mfdyILSLGG TVFVPIIMIV IGLIFripwl qaikAGVTVG IGFVGMGLVI
VMAIdslspp ikvmierfgl alhvfdvgag pasgvgYATA IGAMIIPVIF
LLNVAMLVTr ltktmnvdiy nywhyaitgT VVQLMTGSLI YGVLGAICHA
ALslkmadwt akrvqnivgl eGISIPQGYG SSSVPLFVLL DAIYekipfm 200
kgrnidaqei qkrYGMVGDP VIIGVVLGLI FGLAAGegfk gcaslMITVA
AIMVLFPRMI RLIVEGLLpi sdgarkffqk yfkgrevYIG LDTAVTLGHP
TTIAVGLLLI pimlilasil pgnkVLPLAD LPVAPFFICM ATVIhrgdlv
rtLISGVIVM ITVLLIATQF APYFTemalk ggfsfagesa qisalsvgnm 400
fgwsiseLMS LGIIGVVVAV GIVASVVLFL rkrelse

MW 000 Da; 437 aa


PTS system, glucitol/sorbitol-specific IIBC component (srlA )
function 
interaction 
regulation 
topologycontains EIIB and two EIIC domains
transmembrane domains: 10 (potential)
MW 000 Da; 506 aa


PTS system, trehalose-specific IIBC component (treB )
function 
interaction 
regulation 
topologycontains EIIB and EIIC domain
transmembrane domains: 10 (potential)
MW 000 Da; 473 aa