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| ecce/ proteins of the inner membrane/ secretion |
Putative general secretion pathway protein F
(hofF
)
| function | involved in a general secretion pathway (GSP) for export of proteins
| | interaction |
| | regulation |
| | topology | transmembrane domains: 3 (potential), SP has 4
TMHMM gives 164-186 217-236 364-386
SP gives 164-186 220-236 249-265 360-384
mnyryramtq dgqklqgiid anderqarlr lreeglflld irpqkssgvk
trrprishse ltlftrqlat lsaaalplee slavigqqss nkrlgdvlnq
vrsaileghp lsdalqhfpt lfdslyrtlv kageksglla pvlekladyn
enrqkirskl iqsLIYPCML TTVAIGVVII LLTAVVpkit eqfvhmkqql 200
plstrillgl sdtlqrTGPT LLATVFIVAV GFWLWLkrgn nrhrfhamll
rvaligplic ainsarylrt lsilqssgvp lldgmnlste slnnleirqr
lanaaenvrq gnsihlsleq taifppmmly mvasgeksgq lgtlmvraad
nqetlqqnri altLSIFEPA LIITMALIVL FIVVSVlqpl lqlnsmin
| MW | 44339 Da; 398 aa
|
Protein transport protein HofC
(hofC
)
| function |
| | interaction |
| | regulation |
| | topology | transmembrane domains: 3 (potential)
TMHMM gives 163-185 216-235 368-390
SP gives 165-185 209-229 370-390
maskqlwrwh gitgdgnaqd gmlwaesrtl llmalqqqmv tplslkriai
nsaqwrgdks aevihqlatl lkagltlseg lallaeqhps kqwqallqsl
ahdleqgiaf snallpwsev fpplyqamir tgeltgklde ccfelarqqk
aqrqltdkvk salrYPIIIL AMAIMVVVAM LHFVLpefaa iyktfntplp 200
altqgimtla dfsgeWSWLL VLFGFLLAIA NKLLMrrptw livrqklllr
ipimgslmrg qkltqiftil altqsagitf lqgvesvret mrcpywvqll
tqiqhdisng qpiwlalknt gefsplclql vrtgeasgsl dlmldnlahh
hrentmalad nlaallepAL LIITGGIIGT LVVAMYLPIF hlgdamsgmg 400
| MW | 44450 Da; 400 aa
|
LolC (lolC/ycfU
)
| function | lipoprotein transporter, involved in the release of lipoproteins targeted to the outer membrane from the inner membrane
part of an ATP-dependent transport system LolCDE
| | interaction |
| | regulation |
| | topology | transmembrane domains: 4 (potential)
TMHMM gives 25-47 266-288 318-340 360-382
SP gives 25-45 270-290 310-330 358-378
myqpvalfig lrymrgraad rfgrFVSWLS TIGITLGVMA LVTVLSVmng
ferelqnnil glmpqailss ehgslnpqql petavkldgv nrvapittgd
vvlqsarsva vgvmlgidpa qkdpltpylv nvkqtdlepg kynvilgeql
asqlgvnrgd qirvmvpsas qftpmgrips qrlfnvigtf aansevdgye 200
mlvniedasr lmrypagnit gwrlwldepl kvdslsqqkl pegskwqdwr
drkgelfqav rmeknMMGLL LSLIVAVAAF NIITSLGLMV Mekqgevail
qtqgltprqi mmvfmvqGAS AGIIGAILGA ALGALLASQL nnlmpiigvl
ldgaalpvai epLQVIVIAL VAMAIALLST LYpswraaat qpaealrye
| | MW | 43263 Da; 399 aa
|
LolE (lolE/ycfW
)
| function | lipoprotein transporter, involved in the release of lipoproteins targeted to the outer membrane from the inner membrane
part of an ATP-dependent transport system LolCDE
| | interaction |
| | regulation |
| | topology | transmembrane domains: 4 (potential)
TMHMM gives 20-42 269-291 318-340 374-396
SP gives 24-44 274-294 316-336 376-396
amplslligl rfsrgrrrgG MVSLISVIST IGIALGVAVL IVglsamngf
erelnnrila vvphgeieav dqpwtnwqea ldhvqkvpgi aaaapyinft
glvesganlr aiqvkgvnpq qeqrlsalps fvqgdawrnf kageqqiiig
kgvadalkvk qgdwvsimip nsnpehklmq pkrvrlhvag ilqlsgqldh 200
sfamiplada qqyldmgssv sgialkmtdv fnanklvrda gevtnsyvyi
kswigtygym yrdiqmirAI MYLAMVLVIG VACFNIVSTL VMAVkdksgd
iavlrtlgak dgliraiFVW YGLLAGLFGS LCGVIIGVVV SLqltpiiew
ieklighqfl ssdiyfidfl pseLHWLDVF YVLVTALLLS LLASWYparr 400
asnidparvl sgq
| | MW | 45213 Da; 413 aa
|
Putative general secretion pathway protein M
(pshM
)
| function | involved in a general secretion pathway (GSP) for export of proteins
| | interaction |
| | regulation |
| | topology | transmembrane domains: 1 (potential)
TMHMM gives 15-34
SP gives 17-37
mikswwaeks tsekQIVAAL AVLSLGVFCW LGVIkpidty iaehqshaqk
ikkdikwmqd qasthgllgh paltqpikni lleeakrenl aitlengpdn
tltihpvtap lenvsrwltt aqvtygivie dlqftlagne eitlrhlsfr
eqq
| MW | 17234 Da; 152 aa
|
Protein-export membrane protein SecD
(secD
)
| function | involved in protein-export, one of seven secretory proteins that comprise the prokaryotic protein translocation apparatus
| | interaction |
| | regulation |
| | topology | transmembrane domains: 6 (potential)
TMHMM gives 7-29 450-472 475-497 502-524 548-570 580-602
SP gives 10-29 456-472 477-497 502-518 564-580 586-605
mlnryplwkY VMLIVVIVIG LLYALPNLFg edpavqitga rgvaaseqtl
iqvqktlqee kitaksvale egailarfds tdtqlrarea lmgvmgdkyv
valnlapatp rwlaaihaep mklgldlrgg vhflmevdmd talgklqeqn
idslrsdlre kgipyttvrk ennyglsitf rdakardeai aylskrhpdl 200
vissqgsnql ravmsdarls eareyavqqn inilrnrvnq lgvaepvvqr
qgadrivvel pgiqdtarak eilgatatle frlvntnvdq aaaasgrvpg
dsevkqtreg qpvvlykrvi ltgdhitdst ssqdeynqpq vnisldsagg
nimsnftkdn igkpmatlfv eykdsgkkda ngravlvkqe evinianiqs 400
rlgnsfritg innpnearql slllragali apiqiveert igptlgmqni
eqGLEACLAG LLVSILFMII FYkkFGLIAT SALIANLILI VGIMSLLpga
tLSMPGIAGI VLTLAVAVDA NVLInerike elsngrtvqq aidegyrGAF
SSIFDANITT LIKVIILYAV gtgaikgfaI TTGIGVATSM FTAIVGTRAI 600
VNLLYggkrv kklsi
| MW | 66632 Da; 615 aa
|
Preprotein translocase SecE subunit
(secE
)
| function | essential for protein export, one of seven secretory proteins that comprise the prokaryotic protein translocation apparatus | | interaction |
| | regulation |
| | topology | transmembrane domains: 3 (potential)
TMHMM gives 19-36 40-62 94-116
SP gives 19-36 45-63 93-111
msanteaqgs grgleamkWV VVVALLLVAI VGNYLYrdiM LPLRALAVVI
LIAAAGGVAL LTtkgkatva fareartevr kviwptrqet lhtTLIVAAV
TAVMSLILWG LDGILVrlvs fitglrf
| MW | 13643 Da; 127 aa
|
Protein-export membrane protein SecF
(secF
)
| function | involved in protein-export, one of seven secretory proteins that comprise the prokaryotic protein translocation apparatus | | interaction |
| | regulation |
| | topology | transmembrane domains: 6 (potential)
TMHMM gives 24-46 143-162 169-191 195-217 248-270 275-297
SP gives 23-43 143-163 171-191 197-217 249-265 273-297
maqeytveql nhgrkvydfm rwdYWAFGIS GLLLIAAIVI MGVrgfnwgl
dftggtviei tlekpaeidv mrdalqkagf eepmlqnfgs shdimvrmpp
aegetggqvl gsqvlkvine stnqnaavkr iefvgpsvga dlaqTGAMAL
MAALLSILVY VGfrfewrLA AGVVIALAHD VIITLGILSL FhieIDLTIV 200
ASLMSVIGYS LNDSIVVsdr irenfrkirr gtpyeifnvs ltqtlhrTLI
TSGTTLMVIL MLYLFGGPVL egfsLTMLIG VSIGTASSIY VASALALklg
mkrehmlqqk vekegadqps ilp
| MW | 35382 Da; 323 aa
|
Protein-export membrane protein SecG
(secG
)
| function | involved in protein-export, participates in an early event of protein translocation
| | interaction |
| | regulation |
| | topology | transmembrane domains: 2 (potential)
TMHMM gives 5-22 51-73
SP gives 4-22 55-72
myeaLLVVFL IVAIGLVGLI MLqqgkgadm gasfgagasa tlfgssgsgn
fmtrMTALLA TLFFIISLVL GNInsnktnk gsewenlsap akteqtqpaa
pakptsdipn
| MW | 11365 Da; 110 aa
|
Preprotein translocase SecY subunit
(secY
)
| function | involved in protein-export, interacts with SecA and SecE to allow translocation of proteins across the plasma membrane by forming part of a channel, one of seven secretory proteins that comprise the prokaryotic protein translocation apparatus
| | interaction |
| | regulation |
| | topology | transmembrane domains: 10 (potential)
TMHMM gives 22-44 76-98 119-138 153-175 182-204 215-237 274-296 316-338 373-392 397-414
SP gives 22-43 78-98 122-138 158-175 184-205 215-238 271-292 314-336 372-391 396-419
makqpgldfq sakgglgelk rrLLFVIGAL IVFRIGSFIP IPGIdaavla
klleqqrgti iemfnmfsgg alsraSIFAL GIMPYISASI IIQLLTVVhp
tlaeikkege sgrrkisqYT RYGTLVLAIF QSIGIATGLp nmpgmqglvi
npGFAFYFTA VVSLVTGTMF LMWLGeqite rGIGNGISII IFAGIVAGLP 200
PAIAhtieqa rqgdLHFLVL LLVAVLVFAV TFFVVFVerg qrrivvnyak
rqqgrrvyaa qsthlplkvn magVIPAIFA SSIILFPATI ASWFGGgtgw
nwlttislyl qpgqpLYVLL YASAIIFFCF FYTALVFnpr etadnlkksg
afvpgirpge qtakyidkvm trLTLVGALY ITFICLIPEF MrdamkVPFY 400
FGGTSLLIVV VVIMdfmaqv qtlmmssqye salkkanlkg ygr
| MW | 48511 Da; 443 aa
|
Sec-independent protein translocase protein TatC (tatC/yigU
)
| function | Twin Arg exporter, secretes folded substrates (often containing bound cofactor)
| | interaction |
| | regulation |
| | topology | transmembrane domains: 6 (potential)
TMHMM gives 20-42 74-96 116-138 158-180 193-210 215-237
SP gives 24-44 76-96 116-136 157-177 194-210 212-232
msvedtqpli thlielrkrL LNCIIAVIVI FLCLVYFAND IYhlvsapli
kqlpqgstmi atdvaspfft pikLTFMVSL ILSAPVILYQ VWAFIApaly
kherrlvvpl lvsssLLFYI GMAFAYFVVF PLAFGFLAnt apegvqvstd
iasylsFVMA LFMAFGVSFE VPVAIVLLCW Mgitspedlr kkrpYVLVGA 200
FVVGMLLTpp dvfsqTLLAI PMYCLFEIGV FFSRFYVgkg rnreeendae
aesektee
| | MW | 28876 Da; 258 aa
|
YidC
(yidC
)
| function | involved in insertion of cytoplasmic membrane proteins
| | interaction |
| | regulation |
| | topology | transmembrane domains: 6 (experimental)
TMHMM gives 7-24 346-368 419-441 497-519
SP gives 6-23 343-370 417-446 464-481 494-509 513-535
mdsqrnLLVI ALLFVSFMIW QAWEqdknpq pqaqqttqtt ttaagsaadq
gvpasgqgkl isvktdvldl tintrggdve qallpaypke lnstqpfqll
etspqfiyqa qsgltgrdgp dnpangprpl ynvekdayvl aegqnelqvp
mtytdaagnt ftktfvlkrg dyavnvnynv qnagekplei ssfgqlkqsi 200
tlpphldtgs snfalhtfrg aaystpdeky ekykfdtiad nenlnisskg
gwvamlqqyf atawiphndg tnnfytanlg ngiaaigyks qpvlvqpgqt
gamnstlwvg peiqdkmaav aphldltvdy gwlwfisqpl fkllkWIHSF
VGNWGFSIII ITFIVRGImy pltkaqytsm akmrmlqpki qamrerlgdd 400
kqrisqemma lykaekvnPL GGCFPLLIQM PIFLALYYML Mgsvelrqap
falwihdlsa qdpYYILPIL MGVTMFFIQK MSPTTVtdpm qqkIMTFMPV
IFTVFFLWFp sgLVLYYIVS NLVTIIQQQL IYRGLekrgl hsrekkks
| MW | 61526 Da; 548 aa
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