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ecce/ proteins of the inner membrane/ drug efflux
Acriflavin resistance protein A precursor (acrA )
function 
interaction 
regulation 
topologyattached to the inner membrane by a lipid anchor (potential)
MW 42196 Da; 397 aa


Acriflavin resistance protein B (acrB )
functiondrug efflux pump
interaction 
regulation 
topologytransmembrane domains: 11 (potential), SP has 12

TMHMM gives 10-32 340-359 369-391 438-460 470-492 542-564 873-892 899-921 926-948 975-997 1007-1029
SP gives 10-28 340-359 366-385 392-413 442-460 474-496 539-557 873-892 899-918 925-946 975-993 1007-1029

mpnffidrpI FAWVIAIIIM LAGGLAILKL PVaqyptiap pavtisasyp
gadaktvqdt vtqvieqnmn gidnlmymss nsdstgtvqi tltfesgtda
diaqvqvqnk lqlampllpq evqqqgvsve kssssflmvv gvintdgtmt
qedisdyvaa nmkdaisrts gvgdvqlfgs qyamriwmnp nelnkfqltp 200
vdvitaikaq naqvaagqlg gtppvkgqql nasiiaqtrl tsteefgkil
lkvnqdgsrv llrdvakiel ggenydiiae fngqpasglg iklatganal
dtaaairael akmepffpsg lkivypydtt pfvkisiheV VKTLVEAIIL
VFLVMYLFLq nfratlipTI AVPVVLLGTF AVLAAFGFSI Ntltmfgmvl 400
aigllvddai vvvenvervm aeeglppkea trksmgqIQG ALVGIAMVLS
AVFVPMAFFG gstgaiyrqF SITIVSAMAL SVLVALILTP ALcatmlkpi
akgdhgegkk gffgwfnrmf eksthhytds vggilrstgr yLVLYLIIVV
GMAYLFVRLP SSFLpdedqg vfmtmvqlpa gatqertqkv lnevthyylt 600
keknnvesvf avngfgfagr gqntgiafvs lkdwadrpge enkveaitmr
atrafsqikd amvfafnlpa ivelgtatgf dfelidqagl ghekltqarn
qllaeaakhp dmltsvrpng ledtpqfkid idqekaqalg vsindinttl
gaawggsyvn dfidrgrvkk vyvmseakyr mlpddigdwy vraadgqmvp 800
fsafsssrwe ygsprleryn glpsmeilgq aapgkstgea melmeqlask
lptgvgydwt gmsyqerlsg nqAPSLYAIS LIVVFLCLAA LYeswsipFS
VMLVVPLGVI GALLAATFRG LtndvYFQVG LLTTIGLSAK NAILIVEFak
dlmdkegkgl ieatldavrm rlrpILMTSL AFILGVMPLV ISTGAGSgaq 1000
navgtgVMGG MVTATVLAIF FVPVFFVVVr rrfsrknedi ehshtvdhh

MW113573 Da; 1049 aa


Acriflavin resistance protein D (acrD )
functioncould be a drug efflux pump
interaction 
regulation 
topologytransmembrane domains: 11 (potential), SP has 12

TMHMM gives 10-32 340-362 366-388 438-460 470-492 538-560 868-890 897-919 924-946 972-994 1004-1026
SP gives 10-28 340-359 366-385 392-413 442-460 474-496 538-556 871-890 897-916 923-944 972-990 1004-1026

manffidrpI FAWVLAILLC LTGTLAIFSL PVeqypdlap pnvrvtanyp
gasaqtlent vtqvieqnmt gldnlmymss qssgtgqasv tlsfkagtdp
deavqqvqnq lqsamrklpq avqnqgvtvr ktgdtnilti afvstdgsmd
kqdiadyvas niqdplsrvn gvgdidaygs qysmriwldp aklnsfqmta 200
kdvtdaiesq naqiavgqlg gtpsvdkqal natinaqsll qtpeqfrdit
lrvnqdgsev rlgdvatvem gaekydylsr fngkpasglg vklasganem
ataelvlnrl delaqyfphg leykvayett sfvkasiedV VKTLLEAIAL
VFLVMYLFLQ NFratLIPTI AVPVVLMGTF SVLYAFGYsv ntltmfamvl 400
aigllvddai vvvenverim seegltprea trksmgqIQG ALVGIAMVLS
AVFVPMAFFG gttgaiyrqF SITIVAAMVL SVLVAMILTP ALcatllkpl
kkgehhgqkg ffawfnqmfn rnaeryekgv akilhrsLRW IVIYVLLLGG
MVFLFLRLPT sflpledrgm fttsvqlpsg stqqqtlkvv eqiekyyfth 600
ekdnimsvfa tvgsgpggng qnvarmfirl kdwserdskt gtsfaiiera
tkafnqikea rviassppai sglgssagfd melqdhagag hdalmaarnq
llalaaenpe ltrvrhngld dspqlqidid qrkaqalgva iddindtlqt
awgssyvndf mdrgrvkkvy vqaaapyrml pddinlwyvr nkdggmvpfs 800
afatsrwetg sprleryngy saveivgeaa pgvstgtamd imeslvkqlp
ngfglewtam syqerlsGAQ APALYAISLL VVFLCLAALY eswsvpFSVM
LVVPLGVIGA LLATWMRGLe ndvYFQVGLL TVIGLSAKNA ILIVEFanem
nqkghdlfea tlhacrqrlr pILMTSLAFI FGVLPMATST GAGSggqhav 1000
gtgVMGGMIS ATILAIYFVP LFFVLVrrrf plkprpe

MW113047 Da; 1037 aa


Acriflavin resistance protein E precursor (acrE )
functionmay affect specific membrane functions, such as septum formation during cell division, and cell membrane stability
interaction 
regulation 
topologyattached to the inner membrane by a lipid anchor (potential)
MW 41317 Da; 385 aa


Arsenical pump membrane protein (arsB )
functioninvolved in arsenical resistance, probabaly forms a channel of an arsenic pump
interaction 
regulation 
topologytransmembrane domains: 11 (potential), SP has 13

TMHMM gives 2-19 24-41 48-70 90-109 114-131 141-163 176-198 228-262 274-296 316-335 401-423
SP gives 21-41 46-66 98-118 121-141 152-172 178-198 228-248 249-269 274-294 311-331 337-357 371-391 407-427

mLLAGAIFVL TIVLVIWQPk glgIGWSATL GAVLALVTGV VhpgdipVVW
NIVWNATAAF IAVIIISLLL desgffewaa lhvsrwgngR GRLLFTWIVL
LGAAVAALFa ndgAALILTP IVIAMLLALG Fskgttlafv MAAGFIADTA
SLPLIVSNLV NIVsadffgl gfreyASVMV PVDIAAIVAT LVMLHLYFrk 200
dipqnydmal lkspaeaikd patfktgWVV LLLLLVGFFV LEPLGIPVSA
IAAVGALILF VVakrghain tgkVLRGAPW QIVIFSLGMY LVVYGLrnag
lteylsgvln vladnGLWAA TLGTGFLTAF LSSIMnnmpt vlvgalsidg
stasgvikea mvyanvigcd lgpkitpigs latllwlhvl sqknmtiswg 400
YYFRTGIIMT LPVLFVTLAA LALrlsftl

MW45497 Da; 429 aa


Bicyclomycin resistance protein (bcr )
functioninvolved in sulfonamide and bicyclomycin resistance, probabale membrane translocase
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 7-26 41-63 76-98 102-124 137-159 163-185 219-241 251-273 286-305 310-332 344-366 370-389
SP gives 9-26 49-65 77-98 106-122 138-159 166-185 215-239 251-268 286-302 309-332 345-366 373-390

mttrqhSSFA IVFILGLLAM LMPLSIdmyl palpvisaqf GVPAGSTQMT
LSTYILGFAL GQLiygpmad sfgrkPVVLG GTLVFAAAAV ACALANTIdq
lIVMRFFHGL AAAAASVVIN ALMRdiypke efsrmmSFVM LVTTIAPLMA
PIVGGWVLVw lsWHYIFWIL ALAAILASAM IFFLIketlp perrqpfhir 200
ttignfaalf rhkrvlsyML ASGFSFAGMF SFLSAGPFVY Ieinhiapen
FGYYFALNIV FLFVMTIFNS RFVrrigaln mfrsgLWIQF IMAAWMVISA
LLGLGfwslV VGVAAFVGCV SMVSSNAMAV ILdefphmag tasSLAGTFR
FGIGAIVGAL LSLATFnsaW PMIWSIAFCA TSSILFCLYa srpkkr

MW43366 Da; 396 aa


Multidrug resistance protein A (emrA )
functionthe emr locus confers resistance to substances of high hydrophobicity, EmrA probably participates in a transport system to extrude toxins and drugs from the cell
interaction 
regulation 
topologytransmembrane domains: 1 (potential)

TMHMM gives 23-45
SP gives 26-46

msanaetqtp qqpvkksgkr krLLLLLTLL FIIIAVAIGI YWFLVlrhfe
etddayvagn qiqimsqvsg svtkvwadnt dfvkegdvlv tldptdarqa
fekaktalas svrqthqlmi nskqlqanie vqkialakaq sdynrrvplg
nanligreel qhardavtsa qaqldvaiqq ynanqamilg tkledqpavq 200
qaatevrnaw lalertriis pmtgyvsrra vqpgaqispt tplmavvpat
nmwvdanfke tqianmrigq pvtittdiyg ddvkytgkvv gldmgtgsaf
sllpaqnatg nwikvvqrlp vrieldqkql eqyplrigls tlvsvnttnr
dgqvlankvr stpvavstar eislapvnkl iddivkanag

MW42736 Da; 390 aa


Multidrug resistance protein B (emrB )
functiontranslocase that confers resistance to substances of high hydrophobicity
interaction 
regulation 
topologytransmembrane domains:13 (potential)
SP has 14

TMHMM gives 13-35 50-72 79-101 106-128 140-162 167-189 201-219 234-251 270-292 302-324 336-353 368-390 480-498
SP gives 13-38 52-72 82-100 110-128 137-159 165-189 203-223 234-249 272-295 306-329 336-355 364-387 408-428 482-504

mqqqkplega qlVIMTIALS LATFMQVLDS TIANVaipti agnlgsslsQ
GTWVITSFGV ANAISIPLTG WLakrvgeVK LFLWSTIAFA IASWACGVSS
SlnmlIFFRV IQGIVAGPLI PLSQSLLLnn yppakrsiaL ALWSMTVIVA
PICGPILGGY ISdnyhWGWI FFINVPIGVA VVLMTLQTLr gretrterrr 200
IDAVGLALLV IGIGSLQIMl drgkeldwfs sqeIIILTVV AVVAICFLIV
Weltddnpiv dlslfksrnF TIGCLCISLA YMLYFGAIVL LPqllqevyg
yTATWAGLAS APVGIIPVIL SPIIgrfahk ldmrrLVTFS FIMYAVCFYW
RAYtfepgmd fgasawpQFI QGFAVACFFM PLTTITLSGL pperlaaass 400
lsnftrtlag sigtsitttm wtnresmhha qltesvnpfn pnaqamysql
eglgmtqqqa sgwiaqqitn qgliisaneI FWMSAGIFLV LLGLVWFAkp
pfgagggggg ah

MW55624 Da; 512 aa


Multidrug resistance protein D (emrD )
functionmultidrug resistance drug that participates in a low energy shock adaptive response
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 12-34 47-69 76-95 100-122 135-157 167-184 205-227 242-264 277-296 301-323 330-352 367-386
SP gives 11-31 49-69 76-96 98-118 137-157 165-185 215-235 245-265 279-299 301-321 332-352 367-387

mkrqrnvnlL LMLVLLVAVG QMAQTIYIPA IAdmardlnv regaVQSV
MGAYLLTYGV SQLFYGPISd rvgrrPVILV GMSIFMLATL VAVTTssltV
LIAASAMQGM GTGVGGVMAR TLprdlyert qlrhANSLLN MGILVSPLLA
PLIGGLLdtm wnwracYLFL LVLCAGVTFS MARWmpetrp vdaprtrllt
syktLFGNSG FNCYLLMLIG GLAGIAAfea csgvlmgavl gLSSMTVSIL
FILPIPAAFF GAWFagrpnk rfstlmWQSV ICCLLAGLLM WIPDWFgvmn
VWTLLVPAAL FFFGAGMLFP LATsgamepF PFLAGTAGAL VGGLQNIGSG
VLaslsamlp qtgqgsLGLL MTLMGLLIVL CWLPLAtrms hqgqpv

MW42215 Da; 394 aa


EmrE protein (emrE )
functionprobably prevents the incorporation of methyl viologen into the cells, involved in ethidium bromide efflux
interaction 
regulation 
topologytransmembrane domains: 4 (potential)

TMHMM gives 4-23 30-52 56-78 85-104
SP gives 4-26 32-53 58-76 85-104

mnpYIYLGGA ILAEVIGTTL MKFsegftrL WPSVGTIICY CASFWLLAQT
LAyipTGIAY AIWSGVGIVL ISLLSWGFfg qrldLPAIIG MMLICAGVLI
INLLsrstph

MW11958 Da; 110 aa


Multidrug resistance protein K (emrK )
function 
interaction 
regulation 
topologytransmembrane domains: 1 (potential)

TMHMM gives 16-35
SP gives 17-37

meqinsnkkh snrrkYFSLL AVVLFIAFSG AYAYWsmele dmistddayv
tgnadpisaq vsgsvtvvnh kdtnyvrqgd ilvsldktda tialnkaknn
lanivrqtnk lylqdkqysa evasariqyq qsledynrrv plakqgvisk
etlehtkdtl isskaalnaa iqaykankal vmntplnrqp qvveaadatk 200
eawlalkrtd ikspvtgyia qrsvqvgetv spgqslmavv parqmwvnan
fketqltdvr igqsvniisd lygenvvfhg rvtginmgtg nafsllpaqn
atgnwikivq rvpvevsldp kelmehplri glsmtatidt knediaempe
lastvtsmpa ytskalvidt spiekeisni ishngql

MW42585 Da; 387 aa


Multidrug resistance protein Y (emrY )
function 
interaction 
regulation 
topologytransmembrane domains. 13 (potential), SP has 14

TMHMM gives 7-29 55-77 84-106 110-132 144-166 171-193 206-223 233-255 276-295 305-327 339-358 373-395 484-502
SP gives 9-29 31-51 54-74 85-105 106-126 142-162 173-193 205-225 235-255 274-294 308-328 339-359 365-385 487-507

maitksTPAP LTGGTLWCVT IALSLATFMq mldstisnva iptisgflga
stdeGTWVIT SFGVANAIAI PVTGRLAqri gelRLFLLSV TFFSLSSLMC
SLSTNLdvlI FFRVVQGLMA GPLIPLSQSL LLrnyppekr tfaLALWSMT
VIIAPICGPI LGGYICdnfs WGWIFLINVP MGIIVLTLCL TLLkgretet 200
spvkmNLPGL TLLVLGVGGL QIMldkgrdl dwFNSSTIII LTVVSVISLI
SLVIWestse npildlslfk srnftIGIVS ITCAYLFYSG AIVLMpqllq
etmgYNAIWA GLAYAPIGIM PLLISPLigr ygnkidmrLL VTFSFLMYAV
CYYWRSVTfm ptidftgiil pqFFQGFAVA CFFLPLTTIS FSGLPdnkfa 400
nassmsnffr tlsgsvgtsl tmtlwgrres lhhsqltati dqfnpvfnss
sqimdkyygs lsgvlneinn eitqqslsis aneIFRMAAI AFILLTVLVW
FAkppftakg vg

MW56001 Da; 512 aa


Fosmidomycin resistance protein (fsr )
function 
interaction 
regulation 
topologytransmembrane domains: 10 (potential), SP has 11

TMHMM gives 26-48 58-80 101-123 180-202 223-245 265-287 294-313 317-339 351-373 377-399
SP gives 43-63 64-84 103-123 152-172 178-198 226-246 267-287 295-315 320-340 354-374 379-399

mamseqpqpv agaaasttka rtsfgILGAI SLSHLLNDMI QSLILAIYpl
lqsefsLTFM QIGMITLTFQ LASSLLQPVV gywtdkypmp wslpigmcft
LSGLVLLALA GSFGAVLLAA ALVgtgssvf hpessrvarm asggrhglaq
sifqvggnfg sslgpllaav iiapygkgnV AWFVLAALLA IVVLAQISRW 200
YSaqhrmnkg kpkatiinpl prnkVVLAVS ILLILIFSKY FYMASissyy
tfylmqkfgl siqnAQLHLF AFLFAVAAGT VIGGPVGdki grkYVIWGSI
LGVAPFTLIL PYAslhWTGV LTVIIGFILA SAFSAILVYa qellpgrigm
VSGLFFGFAF GMGGLGAAVL GLIadhTSIE LVYKICAFLP LLGMLTIFLp 400
dnrhkd

MW 43305 Da; 406 aa


Macrolide-specific ABC-type efflux carrier MacB (ybjZ )
functionABC efflux transporter for macrolide antibiotics
interaction 
regulation 
topologytransmembrane domains: 4 (potential), SP has 5

TMHMM gives 273-295 527-549 572-594 609-631
SP gives 273-293 417-437 523-543 576-596 612-632

mtpllelkdi rrsypagdeq vevlkgisld iyagemvaiv gasgsgkstl
mnilgcldka tsgtyrvagq dvatldadal aqlrrehfgf ifqryhllsh
ltaeqnvevp avyaglerkq rllraqellq rlgledrtey ypaqlsggqq
qrvsiaralm nggqvilade ptgaldshsg eevmailhql rdrghtviiv 200
thdpqvaaqa ervieirdge ivrnppaiek vnvtggtepv vntvsgwrqf
vsgfnealtm awralaankm rtLLTMLGII IGIASVVSIV VVGdaakqmv
ladirsigtn tidvypgkdf gdddpqyqqa lkyddliaiq kqpwvasatp
avsqnlrlry nnvdvaasan gvsgdyfnvy gmtfsegntf nqeqlngraq 400
vvvldsntrr qlfphkadvv gevilvgnmp arvigvaeek qsmfgsskvl
rvwlpystms grvmgqswln sitvrvkegf dsaeaeqqlt rllslrhgkk
dfftwnmdgv lktvekttrt lqLFLTLVAV ISLVVGGIGV MNIMLVSVTe
rtreigirma vgarasdvlq qFLIEAVLVC LVGGALGITL SLLIAFtlql 600
flpgweigFS PLALLLAFLC STVTGILFGW Lparnaarld pvdalare

MW70702 Da; 648 aa


MarC (marC/ydeB )
functionMultiple antibiotic resistance
interaction 
regulation 
topologytransmembrane domains: 5 (potential), SP has 6

TMHMM gives 10-32 44-66 71-93 150-172 192-214
SP gives 8-28 45-65 69-89 119-139 155-175 197-217

mldlfkaigL GLVVLLPLAN PLTTVALFLG LAgnmnsaer nrqSLMASVY
VFAIMMVAYY AGQLVMdtfg ISIPGLRIAG GLIVAFIGFR MLFpqqkaid
speaksksee ledepsania fvplampsta gpgtiamiis sastvrqssT
fadWVLMVAP PLIFFLVAVI LWgslrssga imrlvgkggi eAISRLMGFL 200
LVCMGVQFII NGILeiikty h

MW23617 Da; 221 aa


Multidrug translocase MdfA (mdfA )
functionefflux pump driven by the PMF, confers resistance to a very broade spectrum of drugs, confers resistance to basic, aromatic and lipophilic drugs as well as neutral, nonaromatic zwitterionic or nonaromatic hydrophilic antibiotics
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 12-31 51-73 86-103 108-130 143-165 169-188 220-242 257-279 286-308 313-335 348-367 377-399
SP gives 15-32 54-72 83-103 110-130 145-165 167-187 227-247 256-276 288-308 315-335 347-367 379-399

mqnklasgar lGRQALLFPL CLVLYEFSTY Igndmiqpgm lavveqyqag
IDWVPTSMTA YLAGGMFLQW LLGplsdrig rrpvmLAGVV WFIVTCLAIL
LAQnieqFTL LRFLQGISLC FIGAVGYAAI qesfeeavci kiTALMANVA
LIAPLLGPLV GAAWIhvlPW EGMFVLFAAL AAISFFGLqr ampetatrig 200
eklslkelgr dyklvlkngR FVAGALALGF VSLPLLAWIA QSpiiiitge
qlssyeYGLL QVPIFGALIA GNLLLARLTs rrtvrSLIIM GGWPIMIGLL
VAAAATVIss haYLWMTAGL SIYAFGIGLA NAGLVrltlf asdmskgTVS
AAMGMLQMLI FTVGIEIskh awlnggNGLF NLFNLVNGIL WLSLMVIFLk 400
dkqmgnsheg

MW44321 Da; 410 aa


Multidrug resistance-like ATP-binding protein Mdl (mdlB )
function 
interaction 
regulation 
topologytransmembrane domains: 4 (potential), SP has 6

TMHMM gives 28-50 63-85 163-185 249-271
SP gives 26-46 63-83 141-161 165-185 255-275 279-299

mrsfsqlwpt lkrllaygsp wrkplgiAVL MMWVAAAAEV SGPLLISYFI
dnmvaknnlp lkVVAGLAAA YVGLQLFAAG LHYAQsllfn raavgvvqql
rtdvmdaalr qplsefdtqp vgqvisrvtn dtevirdlyv tvvatvlrsa
alvgamlvam fsLDWRMALV AIMIFPVVLV VMVIYqryst pivrrvrayl 200
adindgfnei ingmsviqqf rqqarfgerm geasrshyma rmqtlrldGF
LLRPLLSLFS SLILCGLLML Fgfsasgtie vgvlyafisy lgrlneplie
lttqqamlqq avvagervfe lmdgprqqyg nddrplqsgt ievdnvsfay
rddnlvlkni nlsvpsrnfv alvghtgsgk stlasllmgy ypltegeirl 400
dgrplsslsh salrqgvamv qqdpvvladt flanvtlgrd iseervwqal
etvqlaelar smsdgiytpl geqgnnlsvg qkqllalarv lvetpqilil
deatasidsg teqaiqhala avrehttlvv iahrlstivd adtilvlhrg
qaveqgthqq llaaqgrywq myqlqlagee laasvreees lsa

MW65222 Da; 593 aa


NorM (norM/ydhE )
functionMultidrug efflux
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 7-29 44-66 91-113 128-147 160-180 190-212 241-263 278-300 313-335 350-367 387-409 419-438
SP gives 11-31 53-73 93-113 127-147 161-181 189-209 243-263 277-297 314-334 350-370 387-407 418-438

mqkyisEARL LLALAIPVIL AQIAQTAMGf vdtvmaggys atdMAAVAIG
TSIWLPAILF GHGLLLaltp viaqlngsgr reriahqvrq GFWLAGFVSV
LIMLVLWNAG YIIrsmenid paladkaVGY LRALLWGAPG YLFFQVArnq
ceglaktkpG MVMGFIGLLV NIPVNYIFIY ghfgmpelgG VGCGVATAAV 200
YWVMFLAMVS YIkrarsmrd irnekgtakp dpavmkrliq LGLPIALALF
FEVTLFAVVA LLVsplgivd vaghqiaLNF SSLMFVLPMS LAAAVTIRVG
yrlgqgstld aqTAARTGLM VGVCMATLTA IFTVSlreqi allyndnpeV
VTLAAHLMLL AAVYQISdsi qvigsgilrg ykdtrsIFYI TFTAYWVLGL 400
PSGYILALTd lvvepmgpAG FWIGFIIGLT SAAIMMMLrm rflqrlpsai
ilqrasr

MW49447 Da; 457 aa


SbmA protein (sbmA )
functionrequired for the uptake of peptide antibiotic microcin B17
interaction 
regulation 
topologytransmembrane domains: 8 (potential), SP has 7

TMHMM gives 12-31 57-79 86-108 138-160 206-228 243-265 309-327 337-359
SP gives 12-32 57-77 88-108 138-158 206-226 243-263 332-352

mfksffpkpg tFFLSAFVWA LIAVIFWQAG Ggdwvaritg asgqipisaa
rfwsldFLIF YAYYIVCVGL FALFWFIYSp hrwqyWSILG TALIIFVTWF
LVEVGVAVna wyapfydliq talssphkvt ieqfyreVGV FLGIALIAVV
ISVLNNFFVS hyvfrwrtam neyymanwqq lrhiegaaqr vqedtmrfas 200
tlenmGVSFI NAIMTLIAFL PVLVTLSAhv pelpiighip ygLVIAAIVW
SLMGTGLLAV VGIKLpglef knqrveaayr kelvygedda tratpptvre
lfsavrknYF RLYFHYMYFN IARILYLqvd nvfglfLLFP SIVAGTITLG
LMTQITNVFg qvrgafqyli nswttlvelm siykrlrsfe heldgdkiqe 400
vthtls

MW46459 Da; 406 aa


SugE protein (sugE )
functionconfers resistance to a narrow range of quaternary ammonium compounds.
Initially identified to supresses a groEL mutation and to mimic the effect of groE overexpression
interaction 
regulation 
topologytransmembrane domains: 4 (potential)

TMHMM gives 2-19 29-48 55-77 87-104
SP gives 1-21 29-49 58-78 82-102

mSWIILVIAG LLEVVWAVGl kythgfsrLT PSVITVTAMI VSMALLAWam
kslpVGTAYA VWTGIGAVGA AITGIVLLge sanpmrLASL ALIVLGIIGL
KLSTh

MW 10900 Da; 105 aa


Hypothetical 60.1 kD protein in amn-cbl intergenic region (yeeO )
functionbelongs to matE multi drug efflux family
interaction 
regulation 
topologytransmembrane domains: 11 (potential)

TMHMM gives 101-123 138-160 173-192 212-234 246-268 283-305 318-340 355-377 404-426 441-463 486-508
SP gives 94-114 139-159 174-194 211-231 257-277 281-301 318-338 350-370 404-424 439-459 489-509

mlrhiltakn llsnpifkfp nclpflstvc cicrqfvgen lcsfadspsl
femwfhflql rsalnissal rqvvhgtrwh akrksykvlf wreitplavp
IFMENACVLL MGVLSTFLVS WLGkdamagv gladsfnMVI MAFFAAIDLG
TTVVVAFSLG krdrrrarva trQSLVIMTL FAVLLATLIH HFgeqiidfv 200
agdattevka lALTYLELTV LSYPAAAITL IGSGalrgag ntkipLLING
SLNILNIIIS GILIYGLFsw pglgfvgagl glTISRYIGA VAILWVLAIG
FNPALrislk syfkplnFSI IWEVMGIGIP ASVESVLFTS grlltqmfva
gmgtSVIAGN FIAFSIAALI NLPGSALgsa stiitgrrlg vgqiaqaeiq 400
lrhVFWLSTL GLTAIAWLTA PFAGVMasfy tqdpqvkhvv VILIWLNALF
MPIWSASWVL PAGfkgarda ryamwvsmls mwgcrVVVGY VLGIMLGWGV
VGVWMGMFad wavravlfyw rmvtgrwlwk yprpepqkce kkpvvse

MW60060 Da; 547 aa


Hypothetical 44.7 kD protein in iadA-mcrD intergenic region (yjiO )
function 
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 12-34 49-68 80-99 104-126 138-160 164-186 216-238 253-275 282-304 309-331 344-366 376-395
SP gives 12-32 49-69 79-99 104-124 141-161 168-188 217-237 252-272 283-303 308-328 349-369 374-394

mprfftrhaa tLFFPMALIL YDFAAYLSTD LIQPgiinvv rdfnadvsLA
PAAVSLYLAG GMALQWLLgp lsdrigrrpV LITGALIFTL ACAATMFTTs
mtqFLIARAI QGTSICFIAT VGYVTVqeaf gqtkgikLMA IITSIVLIAP
IIGPLSGAAL mhfmhWKVLF AIIAVMGFIS FVGLLLampe tvkrgavpfs 200
aksvlrdfrn vfcnrLFLFG AATISLSYIP MMSWVAVSpv ilidagsltt
sqFAWTQVPV FGAVIVANAI VARFVkdpte prFIWRAVPI QLVGLSLLIV
GNLLsphvWL WSVLGTSLYA FGIGLIFPTL Frftlfsnkl pkgTVSASLN
MVILMVMSVS VEIGRWLWFn ggrlpFHLLA VVAGVIVVFT LAGLLnrvrq 400
hqaaelveeq

MW44687 Da; 410 aa