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ecce/ periplasmic proteins/ listed by size

---Up to 20 kDa
---20 - 30 kDa
---30 - 40kDa
---40 - 50 kDa
---50 - 60 kDa
---60 - 70 kDa
---70 - 80 kDa
---80 - 90 kDa
---90 - 100 kDa
---Above 100 kDa

Up to 20 kDa
HokC (hokC )
functionToxin
interaction 
regulation 
MW55021 Da; 50 aa


HokD (hokD )
functionToxin
interaction 
regulation 
MW57371 Da; 51 aa


Protein YpdH precursor (ypdH )
functionhas short stretch of homology to PTS EIIB domain
interaction 
regulation 
MW11735 Da; 108 aa


Protein HdeA precursor (hdeA )
function 
interaction 
regulationH-NS-dpendent
MW11858 Da; 110 aa


c-type cytochrome biogenesis protein CycY precursor (cycY )
functionDivalent cation tolerance
interaction 
regulation 
MW12331 Da; 112 aa


Protein FrwD precursor (frwD )
functionhas short stretch of homology to PTS EIIB domain
interaction 
regulation 
MW12637 Da; 113 aa


Chaperone protein PrsD fragment precursor (prsD )
functionmediates assembly of pili
interactionforms soluble multimeric complexes with pili subunits
regulation 
MW13080 Da; 115 aa


YobA proteinr (yobA )
functionpotentially mediates copper resistance by sequestration of copper
interaction 
regulation 
MW13410 Da; 124 aa


11.9 kD protein in parC-mdaB intergenic region precursor (ygiW )
function 
interaction 
regulation 
MW14011 Da; 130 aa


Soluble cytochrome b562 precursor (cybC )
functionElectron-transport protein of unknown function. Its midpoint redox potential is about +180 mV.
interaction 
regulation 
 3d-structure
MW14061 Da; 128 aa


Cytochrome c-type biogenesis protein NrfF precursor (nrfF )
functionmay be required for biogenesis of c-type cytochrome, possible subunit of a heme lyase
interaction 
regulation 
MW14523 Da; 127 aa


Cytochrome c-type protein NapB precursor (napB )
functionsmall subunit of the periplasmic nitrate reductase (NAP), may have role in anaerobic metabolism and essential for nitrate assimilation interactions heterodimer with NapA, NapAB receives electrons from membrane anchored tetrahem NapC-protein
interactionbinds two heme groups per molecule
cofactors 
regulationexpressed at high levels only during aerobic growth
 heterodimer of catalytic subunit and a cytochrome c<
MW16296 Da; 156 aa


Inhibitor of vertebrate lysozyme IVY
(ykfE )
functioninhibitor of lysozyme C
interaction 
regulation 
 dimer
MW16872 Da; 157 aa


Superoxide dismutase precursor (sodC )
functiondestroys radicals
Catalytic activity: 2 Peroxide radical + 2 H+ = O2 + H2O2
interaction 
cofactors 
regulation 
 monomer
3D structure
MW17681 Da; 173 aa


Skp
functionchaperone for OM proteins
interaction 
regulation 
 homotetramer
MW17688 Da; 161 aa


Thiol peroxidase precursor (tpx )
functionantioxidant, removing peroxides or H2O2
interaction 
cofactors 
regulation 
MW17704 Da; 167 aa


Ecotin precursor (eco )
functioninhibitor of a variety of proteases, strength of inhibition does not correlate with particular protease
interaction 
regulation 
 homodimer
3d-structure
MW18192 Da; 162 aa


Spheroplast Protein Y precursor (spy )
function 
interaction 
regulationproduced in spheroplast
MW18199 Da; 161 aa


CpxP precursor (b3913 )
functioninhibitor of CpxA, involved in unfolded stress response in the cell envelope
interactionwith CpxA
regulationvia CpxR
 homologous to spy
MW18965 Da; 166 aa


YbcL protein (ybcL )
functionBelongs to the UPF0098 family, bacterial homologue ofo a Raf kinase inhibitor protein
interaction 
regulation 
MW19476 Da; 183 aa


Hypothetical ABC transporter binding protein YrbD precursor (yrbD )
functionprobably part of a binding-protein-dependent transport system involved in toluene tolerance
interaction 
regulation 
MW19576 Da; 183 aa




20 - 30 kDa

Hypothetical 20.0 kD protein in agaI-mtr intergenic region precursor (yraP )
function 
interaction 
regulation 
MW20028 Da; 191 aa


17.3 kD protein in murA-rpoN intergenic region precursor (yhbN )
function 
interaction 
regulation 
MW20127 Da; 185 aa


18.2 kD protein in cysQ-msrA intergenic region precursor (ytfJ )
function 
interaction 
regulation 
MW20420 Da; 184 aa


Peptidyl-prolyl cis-trans isomerase A precursor (ppiA )
functionaccelerate the folding of proteins
interaction 
cofactors 
regulationinhibition by cyclosporin A
 3d-structure
MW20431 Da; 190 aa


Vitamin B12 transport protein precursor (btuE )
functionnot essential for B12 transport, but auxiliary component of the transport system
interaction 
regulation 
MW20469 Da; 183 aa


Cytochrome c-type protein NrfB precursor (nrfB )
functionterminal reductase of the formate-dependent pathway for nitrite reduction to ammonia
interactionbinds five heme groups per molecule
regulation 
MW20714 Da; 188 aa


PapJ protein precursor (papJ )
functionmaintains pilus integrity, may function as chaperone in the correct assembly of PapA subunits
interaction 
regulation 
MW20729 Da; 193 aa


Thiol:disulfide interchange protein DsbE precursor (ccmG )
functiondisulfide bond formation, also acts as disulfide oxidoreductase in cytochrome c biogenensis
interaction 
cofactors 
regulation 
MW20809 Da; 185 aa


PrsJ protein precursor (prsJ )
functionmaintains pilus integrity, may function as chaperone in the correct assembly of PapA
interaction 
regulation 
MW20836 Da; 193 aa


18,7 kD protein in htrB-dinI intergenic region precursor (yceI )
function 
interaction 
regulation 
MW20912 Da; 191 aa


Osmotically inducable protein Y precursor (osmY )
function 
interaction 
regulationinduced at high osmolariry
MW21074 Da; 201 aa


Outer membrane lipoproteins carrier precursor (lolA )
functiontranslocates lipoproteins from IM to OM
interactionforms complex with lipoprotein
regulation 
MW22628 Da; 204 aa


Thiol:disulfide interchange protein DsbA precursor (dsbA )
functiondisulfide bond formation in e.g. PhoA, OmpA, pilus biogenesis
interactionreoxidised by DsbB
cofactors 
regulation 
 3d-structure
MW23104 Da; 208 aa


Flagella Basal Body P-Ring Formation Protein FlgA precursor (flgA )
functioninvolved in assembly process of p-ring formation
interactionprobably with FlgF
regulation 
MW23519 Da; 219 aa


Acyl-CoA thioesterase I precursor (tesA )
functionhydrolyzes only long chain (C12-C18) acyl thioesters
Catalytic activity: 2-lysophosphatidiylcholine + H2O = glycerophosphocholine + a fatty acid anion
interaction 
cofactors 
regulation 
  monomer
MW 23622 Da; 516 aa


Hypothetical ABC transporter binding protein Yrbc precursor (yrbC )
functionprobably part of a binding-protein-dependent transport system involved in toluene tolerance
interaction 
regulation 
MW23962 Da; 211 aa


Chaperone protein FocC precursor (focC )
functioninvolved in biogenesis of F1C fimbriae
interaction 
regulation 
MW25199 Da; 227 aa


Hypothetical 25.3 kD fimbrial chaperone in gltF-nanT intergenic region precursor
(yhcA )
function 
interaction 
regulation 
MW25339 Da; 224 aa


Hypothetical 25.4 kD fimbrial chaperone in pepN-pyrD intergenic region precursor (ycbR )
functioncould be required for the biogenesis of the putative YcbQ fimbria
interaction 
regulation 
MW25388 Da; 233 aa


Chaperone protein SfmC precursor (sfmC )
functionrequired for the biogenesis of SfmA Fimbriae
interactionbinds and interacts with SfmH
regulation 
MW25457 Da; 230 aa


Thiol:disulfide interchange Protein DsbC precursor (dsbC )
functiondisulfide bond formation, also acts as disulfide isomerase
interactionreoxidised by DsbD
cofactors 
regulation 
 homodimer
MW25622 Da; 236 aa


Hypothetical 25.7 kD fimbrial chaperone in agaI-mtr intergenic region precursor (yraI )
functioncould be required for the biogenesis of the putative YraH fimbria
interaction 
regulation 
MW25676 Da; 231 aa


Class B acid phosphatase precursor (aphA )
functionBroad spectrum dephosphorylating enzyme
interaction 
cofactors 
regulationActivated by Mg2+ and ethanol; inhibited by EDTA, nucleosides, inorganic phosphate and Ca2+
 homotetramer
MW26103 Da; 237 aa


Hypothetical 26.6 kD fimbrial chaperone in gatY-mrp intergenic region precursor
(yehC )
function 
interaction 
regulation 
MW26589 Da; 239 aa


Hypothetical protein YggE
(yggE )
function 
interaction 
regulation 
MW26635 Da; 246 aa


Chaperone protein FimC precursor (fimC )
functionrequired for the biogenesis of type 1 fimbriae
interactionbinds and interacts with FimH
regulation 
 3d-structure
MW26689 Da; 241 aa


Endonuclease I (endA )
functionEndonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotides
interaction 
regulation 
 3d-structure
MW26709 Da; 2351 aa


Chaperone protein PapD precursor (papD )
functionmediates assembly of P pili
interactionforms soluble multimeric complexes with pili subunits
regulation 
 3d-structure
MW26803 Da; 239 aa


Chaperone protein CssC precursor (CSC1) (cssC )
functioninvolved in the biogenesis of the CS6 fimbria
interaction 
regulation 
MW26832 Da; 232 aa


Chaperone protein CssC precursor (CSC2) (cssC )
functioninvolved in the biogenesis of the CS6 fimbria
interaction 
regulation 
MW26716 Da; 232 aa


Arginine-binding protein 2 precursor (artJ )
functionbinds arginine
interaction 
regulation 
MW26829 Da; 243 aa


Chaperone protein Cs31 precursor (CS31)  
functionessential for biogenesis of mature cs3 pili
interaction 
regulation 
MW26908 Da; 241 aa


Arginine-binding protein 1 precursor (artI )
functionbinds arginine
interaction 
regulation 
MW26929 Da; 243 aa


Hypothetical fimbrial chaperone in nei-gltA intergenic region precursor (ybgP )
functioncould be required for the biogenesis of the putative YbgD fimbria
interaction 
regulation 
MW26954 Da; 242 aa


Hypothetical fimbrial chaperone in pepN-pyrD intergenic region precursor (ycbF )
function 
interaction 
regulation 
MW26982 Da; 245 aa


Chaperone protein NfaE precursor (nfaE )
functioninvolved in the biogenensis of Nfa-I adhesin
interaction 
regulation 
MW27048 Da; 247 aa


Chaperone protein EcpD precursor (ecpD )
functionprobably mediates assembly of a pilin
interaction 
regulationinduction by heat shock
MW27054 Da; 246 aa


Glutamine-binding protein precursor (glnH )
functioninvolved in Gln -transport
interaction 
regulationinduction: lack of glutamin
 3d-structure
MW27190 Da; 248 aa


Molybdate-binding protein precursor (modA )
functionbinds molybdate with high specificity and affinity
interaction 
regulation 
MW27364 Da; 257 aa


Thiol:disulfide interchange protein DsbG precursor (dsbG )
functioninvolved in disulfide bond formation
interaction 
cofactors 
regulation 
MW27495 Da; 248 aa


Hypothetical fimbrial chaperone in aroC-fadL intergenic region precursor (yfcS )
function 
interaction 
regulation 
MW27728 Da; 250 aa


Lysine-arginine-ornithine-binding protein precursor (argT)
function 
interactionArgT and HisJ interact with HisP
regulation 
MW27991 Da; 260 aa


Histidine-binding protein HBP precursor (hisJ )
functioncomponent of high-affinity histidine permease
interaction 
regulation 
 3d-structure
MW28483 Da; 260 aa


Hypothetical fimbrial chaperone in ribB-glgS intergenic region precursor (yqiH )
function 
interaction 
regulation 
MW28864 Da; 252 aa


FkbP-type peptidyl-prolyl cis-trans isomerase FkpA precursor (fkpA )
functionfolding of extracytoplasmic proteins
interaction 
cofactors 
regulation 
MW28882 Da; 270 aa


FliY protein precursor (fliY )
functionCystin binding protein
interaction 
regulationsulfate starvation induced
MW29039 Da; 266 aa


Chaperone Protein ClpE precursor (clpE )
functioninvolved in the biogenesis of cs31 capsule-like antigen
interaction 
regulation 
 immunglobulin fold
MW29041 Da; 263 aa


BtuF protein precursor (btuF )
functionVitamin B12 binding protein
interaction 
regulation 
MW29367 Da; 266 aa


Ribonuclease Iprecursor (rna )
functionCleaves the phosphodiester bond between any two nucleotides. Preference for cytidylic or guanylic acid.
interactiontwo isoforms encoded by same gene
cofactors 
regulation 
  four disulfide bonds
MW29617 Da; 268 aa




30 - 40 kDa

Penicillin-insensitive murein endopeptidase precursor (mepA )
functionmurein removal from the sacculus, may faciliate integration of nascent murein strands into sacculus
interactionpenicillin insensitive
cofactors 
regulation 
MW30136 Da; 274 aa


D-ribose-binding protein precursor (rbsB )
functionhigh affinity D-ribose transport, primary chemoreceptor for chemotaxis
interaction 
regulation 
 3d-structure
MW30950 Da; 296 aa


Probable N-acetylmuramoyl-L-alanine amidase YbjR (ybjR )
functionHydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides
interaction 
regulation 
MW31072 Da; 276 aa


Maltose operon protein precursor (malM )
functionnot yet known
interaction 
regulationMalT-dependent
MW31943 Da; 306 aa


Potential choline binding protein (yehz )
function 
interaction 
regulation 
MW32609 Da; 305 aa


Potential YeiE protein (yeiE )
functionunclear, has homology to DNA binding proteins and an unusual signal sequence
interaction 
regulation 
MW32724 Da; 293 aa


D-allose-binding protein precursor (alsB )
functionPart of the binding-protein-dependent transport system alsbac for D-allose
interaction 
regulation 
MW32910 Da; 311 aa


Ferrichrome-binding protein precursor (fhuD )
functioninvolved in high-affinity transport of ironIII -ferrichrome into the cell
interaction 
regulation 
MW32998 Da; 296 aa


IronIII Dicitrate-binding protein precursor (fecB )
functionbinds citrate dependent IronIII
interaction 
regulation 
MW33120 Da; 300 aa


Hypothetical 33.3 kD Protein in ompX-moeB intergenic region precursor (ybiS )
function 
interaction 
regulation 
MW33325 Da; 306 aa


Putative L-asparaginase AsgX (ybiK )
functionL-asparagine + H 2O = L-aspartate + NH 3
interaction 
regulation 
MW33394 Da; 321 aa


Glutamate/aspartate periplasmic binding protein (gltI )
functionPart of the binding-protein-dependent transport system for glutamate and aspartate. Binds to both aspartate and glutamate
interaction 
regulation 
MW33420 Da; 302 aa


Amino-acid ABC transporter binding protein in acrF-rrnD intergenic region precursor (yhdW )
functionprobably part of a binding-protein-dependent aa transport system
interaction 
regulation 
MW33425 Da; 305 aa


High-affinity zinc binding protein ZnuA (znuA )
function 
interaction 
regulation 
MW33777 Da; 310 aa



Penicillin-binding protein7 precursor (pbpG )
functioncell wall formation
interactionpenicillin sensitieve
cofactors 
regulation 
MW34245 Da; 313 aa


Taurine-binding protein precursor (tauA )
function 
interaction 
regulationsulfate starvation induced
MW34266 Da; 320 aa


Ferrienterobactin-binding protein precursor (fepB )
functionbinds ferrienterobactin
interaction 
regulationinduction in part controlled by the amount of available iron
MW34283 Da; 318 aa


32.1 kD protein in ppa-fbp intergenic region precursor (ytfQ )
functionpotential monosaccharide transporter
interaction 
regulation 
MW34344 Da; 318 aa


Protein ErfK precursor (erfK )
function 
interaction 
regulation 
MW34411 Da; 310 aa


Sulfonate-binding protein precursor SsuA (ssuA )
functionspecifically binds aliphatic sulfonates, involved in transport
interaction 
regulationsulfate starvation induced
MW34557 Da; 319 aa


Hypothetical 34.6 kD protein in nhd-mfd intergenic region precursor (ycfS )
function 
interaction 
regulation 
MW34636 Da; 320 aa


Hypothetical periplasmic protein YahB (yahB )
functionunclear, has homology to DNA binding proteins
interaction 
regulation 
MW34866 Da; 310 aa


Hypothetical ABC transporter binding protein YphF precursor (yphF )
functionprobably part of a binding-protein-dependent transport system YphDEF potentially transporting a monosaccharide
interaction 
regulation 
MW35058 Da; 327 aa


FecR protein precursor (fecR )
functionregulates iron dicitrat transport via FecI, sensory transduction
interactioninactivates FecI in absence of citrate
regulation 
MW35532 Da; 317 aa


L-Arabinose-binding protein precursor (araF )
functionhigh affinity to arabinose, can also bind D-galactose and D-fucose
interaction 
regulation 
 3d-structure
MW35541 Da; 329 aa


D-galactose-binding protein precursor (mglB )
functioninvolved in the active transport of D-galactose and D-glucose
role in chemotaxis
interactionwith Trg chemoreceptor
regulation 
 calcium-binding site
3d-structure
MW35712 Da; 332 aa


D-xylose-binding protein precursor (xylF )
functionbinds xylose with high affinity
interactionenergized by high-energy phosphate compounds
regulationsensitiv to cold osmotic shock
MW35734 Da; 330 aa


Sigma E factor regulatory protein RseB precursor (rseB )
functionseems to modulate the activity of RpoE
interaction 
regulation 
MW35749 Da; 318 aa


Hypothetical 36.0 kD protein in avtA-selB intergenic region precursor (yiaO )
function 
interaction 
regulation 
MW35970 Da; 328 aa


Hydrogenase-2 operon protein HybA (hybA )
functionperiplasmic electron-transferring activity of hydrogenase 2
interactionHybBO
cofactorsBinds 4 4Fe-4S clusters
regulation 
MW36003 Da; 328 aa


Glycine betaine-binding protein precursor (proX )
functionmember of multicomponent binding-protein-dependent transport system
interaction 
regulation 
MW36022 Da; 330 aa


Hypothetical 36.1 kD protein in llp-aroD intergenic region precursor (ynhG )
function 
interaction 
regulation 
MW36082 Da; 334 aa


Thiamine-binding protein precursor (sfuA )
function 
interaction 
regulation 
MW36163 Da; 327 aa


Hypothetical protein YneA (yneA )
function 
interaction 
regulation 
MW36685 Da; 340 aa


Sulfate-binding protein precursor (sbp )
functionspecifically binds sulfate, involved in transport
interaction 
regulationsulfate starvation induced
MW36689 Da; 329 aa


L-asparaginase II precursor (ansB )
functionaspartate synthesis
Catalytic activity: L-asparagine + H2O = L-aspartate + NH3
interaction 
cofactors 
regulationinduction by cAMP and anaerobiosis
 homotetramer
3d-structure
MW36850 Da, 348 aa


Potential binding protein for amino acids (yhdW )
functionPutative amino-acid binding protein
interaction 
regulation 
MW37020 Da; 341 aa


Phosphate-binding protein precursor (pstS )
functionBP mediated phosphate transport
interaction 
regulationinduction by phosphate deprivation, subject to positive control by PhoB and negative control by PhoR
 3d-structure
MW37024 Da; 346 aa


Phosphonates-binding protein precursor (phnD )
functionalkylophosphonates binding protein
interaction 
regulation 
MW 37370 Da; 338 aa


Thiosulfate-binding protein precursor (cysP )
functionbinding and transmembrane transport
interaction 
regulation 
MW37614 Da; 338 aa


Protein TorT (torT )
functionrole in torCAD operon induction
interactionbinds putative inducer, interacts with TorS
regulation 
MW37864 Da; 342 aa


Flagella P-Ring Protein precursor (flgI )
functionpart of basal body
interaction 
regulation 
MW38169 Da; 365 aa


Mutarotase (galM )
functionAldose 1-epimerase, converts alpha-aldose to the beta-anomer. Acts on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.
interaction 
regulation 
MW38190 Da; 346 aa


Spermidine/putrescine-binding protein precursor SPBP (potD )
functionpolyamine-binding protein
interaction 
regulation 
 3d-structure
MW38867 Da; 348 aa


Leu/Ile/Val-binding protein LIV-BP precursor (livJ )
functioncomponent of leucine, isoleucine, valine (threonine) transport
interaction 
regulation 
 3d-structure
MW39076 Da; 367 aa


Cytochrome c-type biogenesis protein CcmH precursor (ccmH )
functionmay be required in biogenesis of c-type cytochrome, possible subunit of heme lyase
interaction 
regulation 
 39089 Da; 350 aa


Leucine-specific binding protein precursor (livK )
functioncomponent of the leucine-specific transport system
interaction 
regulation 
 3d-structure
MW39306 Da; 369 aa


Hydrogenase-2 small chain HybO (hybO )
functionNiFe hydrogenase Membrane-bound hydrogenase 2 small subunit
interactionHybAC
cofactorsBinds two 4Fe-4S clusters and one 3Fe-4S cluster
regulation 
MW39652 Da; 372 aa




40 - 50 kDa

Putrescine-binding protein precursor (potF )
functionpolyamine-binding protein
interaction 
regulation 
MW40839 Da; 370 aa


Glycerophosphoryl diester posphodiesterase precursor (glpQ )
functionmultigene fam., hydrolyzes deacylated phospholiopids
Catalytic activity: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate
interaction 
cofactors 
regulation 
MW40843 Da; 358 aa


Penicillin acylase precursor
(ampC )
functionpenicillin resistance
Catalytic activity:
beta-lactam + H2O = a substituted beta-amino acid
the N4-C7 bond of the lactam ring is cleaved
interaction 
cofactors 
regulation 
 monomer
3d-structure
MW41555 Da; 377 aa


Penicillin-binding protein AmpH
(ampH )
functionBinds penicillin & belongs to the beta-lactamase family
interaction 
cofactors 
regulation 
MW41849 Da; 385 aa


Potential polyamine binding protein (ydcS )
function 
interaction 
regulation 
MW42295 Da; 381 aa


Potential binding protein (ynjB )
function 
interaction 
regulation 
MW42844 Da; 388 aa


Maltose-binding protein MBP precursor (malE )
functionbinds maltoligosaccharides, involved inhigh affinity maltose-transport system, chemotaxis
interactionwith MalF and MalG
regulation 
 3d-structure
MW43387 Da; 396 aa


Penicillin-binding protein 6 precursor (dacC )
functionD-alanine carboxypeptidase
Removes C-terminal d-ala residues from sugar-peptide cell wall precursors
Belongs to Ser protease family S11
interaction 
cofactors 
regulation 
MW43609 Da; 400 aa


Penicillin-binding protein5 precursor (dacA )
functionD-alanine carboxypeptidase
Removes C-terminal d-ala residues from sugar-peptide cell wall precursors
Belongs to Ser protease family S11
interaction 
cofactors 
regulation 
MW44444 Da; 403 aa


Glucose-1-phosphatase precursor (agp )
functionrequired for growth in high phosphate with G-1-P as sole carbon source
Catalytic activity: D-glucose 1-phosphate + H2O = D-GLUCOSE + orthophosphate
interaction 
cofactors 
regulationindependent from inorganic phosphate availability, catabolite repression, positively by cAMP/CRP,
 homodimer
MW45683 Da; 413 aa


TolB protein precursor (tolB )
functioninvolved in the TonB-independent uptake of a group of colicins
interaction 
regulation 
 3d-structure
MW45955 Da; 430 aa


Potential binding protein (ycjN )
function 
interaction 
regulation 
MW46808 Da; 430 aa


pH 2.5 acid phosphatase precursor (appA )
functionCatalytic activity: an orthophosphoric monoester + H2O = an alcohol + orthophosphate
interaction 
cofactors 
regulationcAMP regulated, induced when reaching stationary phase, synthesis triggered by phosphate starvation or shift from aerobic to anaerobic condit.
 monomer
MW47056 Da; 432 aa


Protease DegQ precursor
(hhoA )
functionshared specificity with HtrA/DegP
interaction 
cofactors 
regulation 
MW47205 Da; 455 aa


Survival protein SurA precursor (surA )
functionfolding of extracytoplasmic proteins, essential in stationary phase
interaction 
cofactors 
regulation 
MW47283 Da; 428 aa


Putative beta-lactamase YfeW (yfeW )
function 
interaction 
cofactors 
regulation 
MW47752 Da; 434 aa


Glycerol-3-phosphate-binding protein precursor (ugpB )
functionsn-glycerol-3-phosphate and glycerophosphoryl diester-binding
interactionUgpACE
regulation 
MW48452 Da; 438 aa


Alkaline phosphatase precursor (phoA )
functionBroad spectrum dephosphorylating enzyme
interaction 
cofactorsmetalloenzyme containing two zinc atoms and a magnesium ion
regulation 
 three isoforms
3d-structure
Extensively used as a reporter enzyme and in gene fusion experiments
MW49438 Da; 471 aa


Protease DegP (Do) precursor (htrA )
functionrequired at high temp., degradation of damaged prot., chaperone activity at low temperature, shared specificity with DegQ
interaction 
cofactors 
regulationinduction by heat shock
 multimeric; 2 PDZ domains
MW49439 Da; 474 aa




50 - 60 kDa

Penicillin-Binding Protein 4 precursor (dacB )
functionfinal stages in peptidoglycan synthesis
interactionpenicillin sensitive
cofactors 
regulation 
MW51798 Da; 477 aa


SufI Protein precursor (sufI )
functioninvolved in cell division, supresses a ftsI mutation
interaction 
regulation 
MW51858 Da; 470 aa


Cytochrome c552precursor (nrfA )
functionterminal reductase of the formate-dependent pathway for nitrite reduction to ammonia interactions
interactionbinds five heme groups per molecule
regulationinduction in presence of nitrite, subject to glucose and nitrate repression
MW53703 Da; 478 aa


55.5 kD protein in kdgK-dctA intergenic region precursor (yhjJ )
functionmetalloprotease
interaction 
cofactorsbinds zinc?
regulation 
 has lost the active site residues
MW55527 Da; 498 aa


Putative binding protein YliB (yliB )
functionProbably part of the binding-protein-dependent transport system yliABCD
interaction 
cofactors 
regulation 
MW56470 Da; 512 aa


Probable 53.4 kD blue copper protein precursor YacQ (yacK )
functionMulticopper oxidase
interaction 
cofactors 
regulation 
 homodimer
MW56556 Da; 516 aa


Potential binding protein (yddS )
function 
interaction 
regulation 
MW57641 Da; 516 aa


Glucans Biosynthesis Protein MdoG precursor (mdoG )
functioninvolved in MDO synthesis
interaction 
regulation 
MW57912 Da; 511 aa



Nickel-binding protein precursor (nikA )
functionprobably binds nickel
interaction 
regulation 
MW58719 Da; 524 aa


Murein peptide-binding protein precursor (mppA )
functionbinds L-alanyl-gamma-d-glutamyl-meso-diaminopimelate with high affinity
interaction 
regulation 
MW59900 Da; 537 aa


60 - 70 kDa

Dipeptide transport protein precursor (dppA)
functiondipeptide-binding, required for chemotaxis
interaction 
regulationosmotic shockable transport system
 3d-structure
MW60293 Da; 535 aa


Polysialic acid transport protein KpsD precursor (KSD5) (kpsD )
functioninvolved in translocation of PSA across OM, binds polysaccharide
interaction 
regulation 
MW60484 Da; 558 aa


Potential binding protein (ygiS )
function 
interaction 
regulation 
MW60694 Da; 535 aa


UDP-sugar hydrolase precursor (ushA )
functionmultifunctional: hydrolase, 5'-Nucleotidase
Catalytic activity 1: UDP-sugar + H(2)O = UMP + sugar 1-phosphate. Catalytic activity 2: A 5'-ribonucleotide + H(2)O = A ribonucleoside + orthophosphate
interaction 
cofactorsBinds two Zn2+; Co2+ for Nucleotidase
regulationinhibition by an intracellular protein inhibitor
MW60824 Da; 550 aa


Oligopeptide-binding protein precursor (oppA )
functioncomponent of the oligopeptide permease, binds oligopeptides up to five amino acids with high affinity
interaction 
regulation 
MW60899 Da; 543 aa


Glucans biosynthesis protein D (mdoD )
functionProbably involved in the control of the structural glucose backbone of MDOs, MdoG homologue
interaction 
regulation 
MW62758 Da; 551 aa


Peptide transport protein SapA precursor (sapA )
functioninvolved in peptide intake transport system that plays a role in resistance to antimicrobial peptides
interaction 
regulation 
MW61564 Da; 547 aa


Aminoacyltransferase precursor (ggt )
functionrole in glutathion degradation & synthesis,(g-Glutamyl cycle)
Catalytic activity: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid
interaction 
cofactors 
regulation 
 consists of two polypeptide chains, which are synthesised from a single polypeptide
MW61768 Da, 580 aa


Hydrogenase-2 large chain (hybC )
functionNiFe hydrogenase, H2 + A = AH 2
interactionHeterodimer of a large and a small subunit
cofactorsBinds 1 nickel ion per subunit
regulation 
MW62360 Da; 566 aa


Putative sulfatase YdeN (ydeN )
functionbelongs to the sulfatase family
interaction 
cofactors 
regulation 
MW62802 Da; 560 aa


Trehalase precursor (treA )
functionhydrolyses alpha- 1,1 glycosidic bond in trehalose
interaction 
cofactors 
regulationslightly induced by high osmolarity and stationary phase
MW63636 Da; 565 aa


NiFe hydrogenase subunit (hyaB )
functionMembrane-bound hydrogenase 1 large subunit, catalytic activity: H 2+ A = AH 2
interaction 
cofactors 
 might be cotranslocated with HyaA which has a proper TAT signal sequence
MW66253 Da; 579 aa


AsmA Protein precursor (asmA )
functioninvolved in inhibitionof assembly of mutant OmpF proteins, could be involved in OM protein assembly
interaction 
regulation 
MW68962 Da; 617 aa



Potential binding protein (yejA )
function 
interaction 
regulation 
MW69669 Da; 604 aa



60 - 70 kDa

2',3'-Cyclic-nucleotide 2'-phosphodiesterase precursor (cpdB )
functionbifunctional, catalyzes two consecutive reactions converting 2',3'-cyclic-nucleotide to 3'-nucleotide and then 3'-nucleotide to nucleic acid and phosphate
interaction 
cofactors 
regulation 
  two distinguishable active sites
MW70832 Da; 647 aa


Lytic murein transglycosylase precursor (slt )
functionMurein-degrading, may play role in recaycling muropeptides during cell elongation and/or cell division
interactionenergy conserving reaction
cofactors 
regulation 
 tightly associated with murein sacculus
3d-structure
MW73369 Da; 645 aa


Biosynthetic arginine decarboxylase precursor (ADC) (speA )
functionbiosynthetic and biodegradative form, first step in the spermidine synthesis from arginine, the biodegradive form may ply a role in regulating pH by consuming proteins
interaction 
cofactors pyridoxal phosphate and Mg2+
regulationinduction: growth in acidic enriched medium containing arginine (biodegr.), growth in MMA at neitral pH (biosynth.), repression of speA and feedback inhibition of ADC by putrescine and spermidine,
 homotetramer
MW73983 Da; 658 aa


Alpha-amylase precursor (malS )
functionAlpha-amylase; degradation of maltooligosaccharides with a preference for chain length longer than 6 glucose units
interaction 
cofactors 
regulation MalT (maltose regulon)
 monomer
2 disulfide bonds
MW75712 Da; 676 aa


Tail specific protease precursor (prc )
functionselectively degrades proteins with nonpolar C- terminus (that arises for example from the action of 10sRNA), PBP3 maturation
interaction 
cofactors 
regulation 
MW76663 Da; 682 aa




80 - 90 kDa

Beta-glucosidase precursor (bglX )
functionhydrolysis of terminal non-reducing beta-D glucose residues
interaction 
cofactors 
regulation 
MW83460 Da; 765 aa


Copper amine oxidase precursor (maoA )
functioninitial steps of 2-phenylethylamine catabolism
Catalytic activity: 2-Phenylethylamine + H2O + O2 = Phenylacetaldehyde + NH3 + H2O2
interaction 
cofactorscopper and topaquinon
regulation 
 homodimer
3D-structure
MW84378 Da; 757 aa




Hypothetical protein YgjK (ygjK )
function 
interaction 
cofactors 
regulation 
MW88321 Da; 783 aa


Putative dimethyl sulfoxide reductase chain YnfE (ynfE )
functionDMSO reductase
interactionwith YfnF and YfnG
cofactorsMolybdenum (molybdopterin); may bind a 4Fe-4S cluster
regulation 
MW89780 Da; 808 aa


Putative dimethyl sulfoxide reductase chain YnfF (ynfF )
functionDMSO reductase
interactionwith YfnE and YfnG
cofactorsMolybdenum (molybdopterin); may bind a 4Fe-4S cluster
regulation 
MW89987 Da; 807 aa


90 - 100 kDa

Nitrate reductase precursor (napA )
functiona role in anaerobic growth with limiting concentrations of nitrate, large subunit of the periplasmic nitrate reductase (NAP)
Catalytic activity: nitrite + acceptor = nitrate + reduced acceptor
interaction 
cofactorsmolybdopterin guanine dinucleotide (MGD)
regulationexpressed during anaerobic growth (via FNR), further induction by low concentrations of nitrate (via NarP)
MW93042 Da; 828 aa

Trimethylamine-N-oxide reductase precursor (torA )
functionreduces trimethylamine-n-oxide into trimethylamine, an anaerobic reaction coupled to energy yielding reaction
Catalytic activity: NADH + Trimethylamine-N-Oxide = NAD+ + Trimethylamine + H2O
interaction 
cofactors 
regulation 
 contains molybdopterin
MW94456 Da; 848 aa


Penicillin acylase precursor (pac )
functionpenicillin resistance
Catalytic activity: penicillin + H2O = a fatty acid anion + 6-aminopenicillanate
interaction 
cofactors 
regulation 
 heterodimer
3d-structure
MW94642 Da; 846 aa




Probable bifunctional chitinase/lysozyme precursor (chiA )
functionhydrolysis of [[beta]]-1,4 glucosidic linkages between N-acetylmuramic acid and N-acetylglucosamine and/or chitin degradation
interaction 
cofactors 
regulation 
MW97057 Da; 897 aa


Above 100 kDa

ProteaseIII precursor (ptr )
functionMay prefer small substrates
interaction 
cofactorsrequires divalent cations, binds Zn2+
regulation 
 monomer
MW107708 Da; 962 aa


Formate dehydrogenase alpha subunit FdnG (fdnG )
function
interaction 
cofactors1 molybdenum ion, 2 molybdopterin guanine dinucleotide (MGD) groups, 1 4Fe-4S cluster, and 1 selenocysteine per subunit
regulation 
MW112916 Da; 1015 aa