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ecce/ proteins of the inner membrane/ electron transport

Electron Transport
cytochromes, and
cytochrome biosynthesis proteins



Electron Transport

Anaerobic formate dehydrogenase, nitrate-inducible, cytochrome b556 subunit gamma (fdnH )
functionanaerobic nitrate respiration
formate dehydrogenase is a membrane bound complex formed by subunits alpha, beta, gamma
interaction 
regulationinduction: by nitrate, under anaerobic conditions
topologytransmembrane domains: 1 (potential)

TMHMM gives 260-279
SP gives 259-281

mametqdiik rsatnsitpp sqvrdykaev aklidvstci gckacqvacs
ewndirdevg hcvgvydnpa dlsakswtvm rfseteqngk lewlirkdgc
mhcedpgclk acpsagaiiq yangivdfqs encigcgyci agcpfniprl
nkednrvykc tlcvdrvsvg qepacvktcp tgaihfgtkk emlelaeqrv 200
aklkargyeh agvynpegvg gthvmyvlhh adqpelyhgl pkdpkidtsv
slwkgalkpL AAAGFIATFA GLIFHYIGIg pnkevdddee dhhe

MW32238 Da; 294 aa


Anaerobic formate dehydrogenase, nitrate-inducible, cytochrome b556 subunit beta (fdnI )
functionanaerobic nitrate respiration
formate dehydrogenase is a membrane bound complex formed by subunits alpha, beta, gamma
interaction 
regulationinduction: by nitrate, under anaerobic conditions
topology
transmembrane domains: 4 (potential)

TMHMM gives 21-40 55-77 117-139 154-176
SP gives 20-40 55-75 115-135 156-176

mskskmivrt kfidrachwt VVICFFLVAL SGISFFFPTL qwltqtfgtp
qmgrILHPFF GIAIFVALMF MFVRFVHhni pdkkdipwll nivevlkgne
hkvadvgkyn agqkmmFWSI MSMIFVLLVT GVIIWRPYFa qyfpmqvvry
sllIHAAAGI ILIHAILIHM YMAFWVkgsi kgmiegkvsr rwakkhhprw 200
yreiekaeak keseegi

MW25368 Da; 217 aa


Aerobic formate dehydrogenase, cytochrome b556 subunit beta (fdoH )
functionaerobic nitrate respiration
formate dehydrogenase is a membrane bound complex formed by subunits alpha, beta, gamma
interaction 
regulation 
topologytransmembrane domains: 1 (potential), TMHMM gives 0

TMHMM gives
SP gives 261-279

mayqsqdiir rsatngltpa pqardfqeev aklidvttci gckacqvacs
ewndirdtvg nnigvydnpn dlsakswtvm rfseveqndk lewlirkdgc
mhcsdpgclk acpaegaiiq yangivdfqs eqcigcgyci agcpfdiprl
npednrvykc tlcvdrvvvg qepacvktcp tgaihfgtke smktlaserv 200
aelktrgydn aglydpagvg gthvmyvlhh adkpnlyhgl penpeisetv
kfwkgiwkpL AAVGFAATFA ASIFHYVGVg pnradeeenn lheekdeerk

MW33100 Da; 300 aa


Aerobic formate dehydrogenase, cytochrome b556 subunit gamma (fdoI )
functionaerobic nitrate respiration
formate dehydrogenase is a membrane bound complex formed by subunits alpha, beta, gamma
interaction 
regulation 
topologytransmembrane domains: 4 (potential)

TMHMM gives 21-40 55-77 114-136 151-173
SP gives 18-32 54-72 113-130 152-170

mkrrdtivry taperinhwi TAFCFILAAV SGLGFLFPSF nwlmqimgtp
qlarILHPFV GVVMFASFII MFFRYWHhnl inrddifwak nirkivvnee
vgdtgrynfg qkcVFWAAII FLVLLLVSGV IIWRPYfapa fsipvirfal
MLHSFAAVAL IVVIMVHIYA ALWvkgtita mvegwvtsaw akkhhprwyr 200
evrkttekka e

MW24606 Da; 211 aa


Cytochrome c-type protein NapC (napC )
functionmediates electron flow from quinones to NapAB complex
cofactorsbinds four heme groups per molecule
regulation 
topologytransmembrane domains: 1 (potential)

TMHMM gives 21-43
SP gives 24-44

mgnsdrkpgl ikrlwkwwrt PSRLALGTLL LIGFVGGIVF WGGfntgmek
anteefcisc hemrntvyqe ymdsvhynnr sgvratcpdc hvphefvpkm
irklkaskel ygkifgvidt pqkfeahrlt maqnewrrmk dnnsqecrnc
hnfeymdtta qksvaakmhd qavkdgqtci dchkgiahkl pdmrevepgf 200

MW23100 Da; 200 aa


NrfD protein (nrfD )
functionprobably involved in electron transfer from quinones to c-type cytochrome
interaction 
regulation 
topologytransmembrane domains: 8 (potential)

TMHMM gives 15-37 57-76 91-113 147-169 179-201 222-241 256-278 290-312
SP gives 18-38 57-73 90-112 150-170 180-199 222-242 258-278 288-310

mtqtsafhfe slvwDWPIAI YLFLIGISAG LVTLAVLlrr fypqaggads
tllrttLIVG PGAVILGLLI LVFHLTrpwt fwklmfhysf TSVMSMGVML
FQLYMVVLVL WLAkifehdl lalqqrwlpk lgivqkvlsl vtpvhrGLET
LMLVLAVLLG AYTGFLLSAl ksypflnnPI LPVLFLFSGI SSGAAVALIA 200
Mrirqrsnph steaqfvhrm eIPVVWGEIF LLVAFFVGLA Lgddgkvral
vaalgGGFWT WWFWLGVAGL GLIVPMLLkp wvnrssgipA VLAACGASLV
GVLMLRFFIL YAgqltva

MW35113 Da; 318 aa


RnfD (rnfD/ydgO )
functionMay be part of a membrane complex involved in electron transport
Composed of at least six subunits; RnfABCDE and RnfG
interaction 
regulation 
topologytransmembrane domains: 10 (potential), SP has 8

TMHMM gives 20-39 43-65 78-109 124-143 148-170 214-236 243-262 272-294 301-318 323-342
SP gives 20-40 89-109 123-143 214-234 242-262 267-287 301-321 322-342

mvfriasspy thnqrqtsrI MLLVLLAAVP GIAAQLWFFg wgTLVQILLA
SVSALLAEAL VLklrkqsva atlkdnsALL TGLLLAVSIP PLAPWWMVVL
GTVFAVIIAk qlygglgqnp fnpAMIGYVV LLISFPVQMT SWLppheIAV
NIPGFIDAIQ VIFSGHTASG gdmntlrlgi dgisqatpld tfktsvragh 200
sveqimqypi ysgILAGAGW QWVNLAWLAG GVWLLWqkai rwHIPLSFLV
TLALCAMLGW LFspetlaap qIHLLSGATM LGAFFILTDP VTASttnrgr
LIFGALAGLL VWLIRSFGgy pdGVAFAVLL ANITVPLIDY YTrprvyghr
kg

MW38140 Da; 352 aa


RnfE (rnfE/ydgQ )
functionMay be part of a membrane complex involved in electron transport
Composed of at least six subunits; RnfABCDE and RnfG
interaction 
regulation 
topologytransmembrane domains: 6 (potential), TMHMM has 5

TMHMM gives 34-56 69-87 91-113 126-148 183-205
SP gives 18-38 39-59 63-83 86-106 125-145 182-202

mseikdvivq glwknnsaLV QLLGLCPLLA VTSTATnaLG LGLATTLVLT
LTNLTISTLr hwtpaeirIP IYVMIIASVV SAVQMLInay AFGLYQSLGI
FIPLIVTNCI VVGraeafaa kkgpaLSALD GFSIGMGATC AMFVLGSLre
iigngtlfdg adallgswak vlrveifhtd spFLLAMLPP GAFIGLGLML 200
AGKYLiderm kkrraeaaae ralpngetgn v

MW24459 Da; 231 aa


Cytochromes

TorY (torY/yecK )
functionCytochrome c-type protein, part of the anaerobic respiratory chain of TMAO reductase 2 TorZ(BisZ). Required for electron transfer to TorZ
interactionbinds five heme groups per molecule
regulation 
topologytransmembrane domains: 1 (potential)

TMHMM gives 7-26
SP gives 9-25

mrgkkrIGLL FLLIAVVVGG GGLLLAqkvl hktsdtafcl schsmskpfe
eyqgtvhfsn qkgiraecad chipksgmdy lfaklkaskd iyhefvsgki
dsddkfeahr qemaetvwke lkatdsatcr schsfdamdi asqsesaqkm
hnkaqkdset cidchkgiah fppeikmddn aahelesqaa tsvtngahiy 200
pfktshigel atvnpgtdlt vvdasgkqpi vllqgyqmqg sentlylaag
qrlalatlse egikaltvng ewqadeygnq wrqaslqgal tdpaladrkp
lwqyaekldd tycagchapi aadhytvnaw psiakgmgar tsmseneldi
ltryfqynak ditekq

MW40286 Da; 366 aa


Probable Ni/Fe-hydrogenase b-type cytochrome subunit (hybB )
functionprobable b-type cytochrome
interaction 
regulation 
topologytransmembrane domains: 10 (potential), SP has 11

TMHMM gives 13-32 52-74 86-108 128-150 171-193 208-227 248-270 285-307 314-336 351-373
SP gives 12-32 35-55 59-79 91-111 134-154 169-189 208-228 250-270 282-302 334-354 356-376

mshdpqplgg kiISKPVMIF GPLIVICMLL IVkrlvfglg svsdlnggfp
wGVWIAFDLL IGTGFACGGW ALAWavyvfn rgqyhPLVRP ALLASLFGYS
LGGLSITIdv grywnlpyfy ipghfnvNSV LFETAVCMTI YIGVMALEFA
palferlgwk vslqrlnkvm FFIIALGALL PTMHQSSMGS LMIsagykvh 200
plwqsyeMLP LFSLLTAFIM GFSIVIFegs lvqaglrgng pdekslfVKL
TNTISVLLAI FIVLRFGELI yrdklslafa gdfySVMFWI EVLLMLFPLV
VLRVANVrnd srmLFLSALS ALLGCATWRL TYSLVAfnpg ggyayfptwe
ELLISIGFVA IEICAYIVLI RLLpilpplk qndhnrheas ka

MW43574 Da; 392 aa


Probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit (hyaC )
functionprobable b-type cytochrome
interaction 
regulation 
topologytransmembrane domains: 4 (potential)
MW27597 Da; 235 aa


Succionate dehydrogenase cytochrome b556 subunit (sdhC )
functionmono-heme cytochrome of the succinate dehydrogenase complex, tricarboxylic acid cycle
interaction 
regulation 
topologypart of an enzyme complex
transmembrane domains: 3 (potential)


MW14299 Da; 129 aa


Cytochrome c-type protein TorC (torC )
functionpart of respiratory chain of trimethylamine-N-oxide reductase
interaction 
regulation 
topologytransmembrane domains: 1 (potential)

TMHMM gives 17-39
SP gives 17-37

mrklwnalrr psarwsVLAL VAIGIVIGIA LIVLPHVGIk vtsttefcvs
chsmqpvyee ykqsvhfqna sgvraechdc hippdipgmv krkleasndi
yqtfiahsid tpekfeakra elaerewarm kennsatcrs chnydamdha
kqhpeaarqm kvaakdnqsc idchkgiahq lpdmssgfrk qfdelrasan 200
dsgdtlysid ikpiyaakgd keasgsllpa sevkvlkrdg dwlqieitgw
tesagrqrvl tqfpgkrifv asirgdvqqq vktlekttva dtntewsklq
atawmkkgdm vndikpiway adslyngtcn qchgapeiah fdangwigtl
ngmigftsld kreertllky lqmnasdtag kahgdkkeek

MW43606 Da; 390 aa


Cytochrome Biosynthesis

Heme exporter protein B (ccmB )
functionrequired for the transport of heme to the periplasm for biogenesis of c-type cytochromes
interaction 
regulation 
topologytransmembrane domains: 6 (potential)

TMHMM gives 21-40 44-66 97-119 129-151 158-180 195-217
SP gives 21-41 45-65 101-121 128-148 159-179 193-213

mmfwrifrle lrvafrhsae IANPLWFFLI VITLFPLSIG pepQLLARIA

PGIIWVAALL SSLLALerlf rddlqdgsle qlmllplplp avvlakVMAH
WMVTGLPLLI LSPLVAMLLg mdvygwqvMA LTLLLGTPTL GFLGAPGVAL
TvglkrgGVL LSILVLPLTI PLLIFATAAM daasmhlpvd gylaILGALL 200
AGTATLSPFA TAAALRIsiq

MW23618 Da; 220 aa


Heme exporter protein C (ccmC )
functionrequired for the transport of heme to the periplasm for biogenesis of c-type cytochromes
interaction 
regulation 
topologytransmembrane domains: 6 (potential)

TMHMM gives 21-43 63-85 92-114 129-148 155-177 204-226
SP gives 21-41 64-84 91-111 129-149 160-180 206-226
mwktlhqlai pprlyqicgw FIPWLAIASV VVLTVGWIWG FGFapadyqq
gnsyriiylh vpAAIWSMGI YASMAVAAFI GLVWQmkman lAVAAMAPIG
AVFTFIALVT GSAWgkpmwg twwvwdarLT SELVLLFLYV GVIALWHAfd
drrlAGRAAG ILVLIGVVNL PIIHYSVeww ntlhqgstrm qqsidpamrs 200
plrWSIFGFL LLSATLTLMR MRNLILlmek rrpwvselil krgrk

MW27885 Da; 245 aa


Heme exporter protein D (ccmD )
functionrequired for the transport of heme to the periplasm for biogenesis of c-type cytochromes
interaction 
regulation 
topologytransmembrane domains: 1 (potential)

TMHMM gives 15-37
SP gives 18-37

mtpafaswne ffamGGYAFF VWLAVVMTVI PLVVLVVhsv mqhrailrgv
aqqrarearl raaqqqeaa

MW7745 Da; 69 aa


Heme exporter protein E (ccmE )
functionrequired for the transport of heme to the periplasm for biogenesis of c-type cytochromes, possible subunit of a heme lyase
interaction 
regulation 
topologytransmembrane domains: 1 (potential)

TMHMM gives 7-29
SP gives 9-29

mnirrkNRLW IACAVLAGLA LTIGLVLYAl rsnidlfytp geilygkret
qqmpevgqrl rvggmvmpgs vqrdpnslkv tftiydaegs vdvsyegilp
dlfregqgvv vqgelekgnh ilakevlakh denytppeve kameanhrrp
asvykdpas

MW17698 Da; 159 aa


Heme exporter protein F (ccmF )
functionrequired for the transport of heme to the periplasm for biogenesis of c-type cytochromes, possible subunit of a heme lyase
interaction 
regulation 
topologytransmembrane domains: 15 (potential)

TMHMM gives 10-29 41-63 95-114 121-143 176-198 211-233 248-265 272-294 309-331 351-373 393-415 422-444 448-470 482-504 610-629
SP gives 9-29 42-62 94-114 121-141 176-196 211-231 236-256 274-294 312-332 351-371 390-410 425-445 448-468 482-502 609-629

mmpeignglL CLALGIALLL SVYPLWGVAr gdarmmassr LFAWLLFMSV
AGAFLVLVNA FVVndftvty vasnsntqlp vwyrvaatwg ahegSLLLWV
LLMSGWTFAV AIFSqripld IVARVLAIMG MVSVGFLLFI LFTsnpfsrt
lpnfpiegrd lnpllqdpgl ifhppLLYMG YVGFSVAFAF AIASLLSGrl 200
dstyarftrp WTLAAWIFLT LGIVLGSAWA YYElgwggww fwdpvenASF
MPWLVGTALM HSLAVteqra sFKAWTLLLA ISAFSLCLLG TFLVrsgvlv
svhafasdPA RGMFILAFMV LVIGGSLLLF Aarghkvrsr vnnalwsres
LLLANNVLLV AAMLVVLLGT LLPlvhkqlg lgsisigepf fnTMFTWLMV 400
PFALLLGVGP LVRWGrdrpr kIRNLLIIAF ISTLVLSLLL PWLFeskVVA
MTVLGLAMAC WIAVLAIAEA alrisrgtkt tFSYWGMVAA HLGLAVTIVG
IAFSqnysve rdvrmksgds vdiheyrftf rdvkevtgpn wrggvatigv
trdgkpetvl yaekryynta gsmmteaaid ggitrdlyaa lgeelengaw 600
avrlyykpfV RWIWAGGLMM ALGGLLCLFd pryrkrvspq ktapeav

MW71389 Da; 647 aa


Cytochrome c-type biogenesis protein NrfE (nrfE )
functionmay be required for the biogenesis of c-type cytochromes, possible subunit of a heme lyase
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 21-43 78-97 104-126 156-178 191-213 223-245 258-280 295-314 335-357 372-394 401-423 526-545
SP gives 26-46 77-97 104-124 158-178 193-213 222-242 256-276 294-314 333-353 376-396 399-419 525-545

mltpltafag vrlrwpammr LTCIGILAQF AVLLLAFAVL TYCflisdfs
viyvaqhsys llswelklaa vwgghegSLL LWVLLLSAWS ALFAWHYrqq
tdpLFPLTLA VLSLMLAALL LFVVLWsdpf vrifppaieg rdlnpmlqhp
glifhPPLLY LGYGGLMVAA SVALASLLrg efdgacaris WRWALPGWSA 200
LTAGIILGSW WAYcelglgr lvVLGSVENA SLLPWLSATA LLHSLsltrq
rgifchwSLL LAIVTLMLSL LGTLIVRSGI lvsvhafald nvraVPLFSL
FALISLASLA LYGWrardgg pavhfsglsr emliLATLLL FCAVLLIVLV
GTLYPMIygl lgwgrlsvga pYFNRATLPF GLLMLVVIVL ATFVsgkrvq 400
LPALVAHAGV LLFAAGVVVS SVSrqeisln lqpgqqvtla gytfrfecld
lqakanytse kaivalfdhq qrigeltper afyearrqqm mepsirwngi
hdwyavmgek tgpdryafrl yvqsgVRWIW GGGLLMIAGA LLSGWrgkkr
de

MW60884 Da; 552 aa