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ecce/ proteins of the inner membrane/ amino acid&peptide transport

Amino Acid Permeases
Antiporters for Amino Acids
Symporters for Amino Acids
Efflux Systems for Amino Acids



Amino Acid Permeases

L-asparagine permease (ansP )
functionasparagine permease
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 37-59 64-86 107-129 144-166 171-193 213-235 260-282 302-324 351-373 377-399 420-442 446-468
SP gives 34-54 58-78 109-129 146-166 171-191 219-239 264-284 298-318 353-373 378-398 422-442 448-468

mskhdtdtsd qhaakrrwln aheegyhkam gnrqvqMIAI GGAIGTGLFL
GAGARLQMAg palALVYLIC GLFSFFILRA LGELVLhrps sgsfvsyare
flgekaAYVA GWMYFINWAM TGIVDITAVa lymhywgafg gvpQWVFALA
ALTIVGTMNM IGVKWFaeme FWFALIKVLA IVTFLVVGTV FLGsgqpldg 200
nttgfhlitd ngGFFPHGLL PALVLIQGVV FAFASiemvg taageckdpq
tmvpkainsV IWRIGLFYVG SVVLLVMLLP WSayqagqsp fvtffsklgv
pYIGSIMNIV VLTAALSSLN SGLYctgril rsmamggsap sfmakmsrqh
VPYAGILATL VVYVVGVFLN YLVpsrVFEI VLNFASLGII ASWAFIIVCq 400
mrlrkaikeg kaadvsfklP GAPFTSWLTL LFLLSVLVLM AFdypNGTYT
IAALPIIGIL LVIGWFGVrk rvaeihstap vveedeekqe ivfkpetas

MW54233 Da; 499 aa


Aromatic amino acid transport protein AroP (aroP )
functionpermease, involved in the transport of aromatic amino acids
interaction 
regulationinduction: its activity is regulated by protein TyrR
topologytransmembrane domains: 12 (potential)

TMHMM gives 20-42 47-66 87-109 119-141 154-176 199-221 241-263 283-305 332-354 358-380 400-422 427-446
SP gives 21-41 43-63 87-107 118-138 156-176 202-222 241-261 272-292 334-354 359-379 401-421 426-446

mmegqqhgeq lkrglknrhI QLIALGGAIG TGLFLGSASV IQsagpGIIL
GYAIAGFIAF LIMRQLgemv veepvagsfs hfaykyWGSF AGFASGWNYW
VLYVLVAMAe ltavgkyiQF WYPEIPTWVS AAVFFVVINA Inltnvkvfg
emeFWFAIIK VIAVVAMIIF GGWLLFsgng gpqatvsnlw dqggflphAF 200
TGLVMMMAII MFSFGGLELV Gitaaeadnp eqsipkatnq VIYRILIFYI
GSLAVLLSLM PWTrvtadts pfvlifhelg dtFVANALNI VVLTAALSVY
NSCVYcnsrm lfglaqqgna pkalasvdkr gVPVNTILVS ALVTALCVLI
NYLApesAFG LLMALVVSAL VINWAMISLA hmkfrrakqe qgvvtrfpaL 400
LYPLGNWICL LFMAAVLVIM LMtrgmAISV YLIPVWLIVL GIGYLFkekt
akavkah

MW49763Da; 457 aa


Arginine transport system permease protein ArtM (artM )
functionpart of binding-protein-dependent transport system for arginine, probably responsible for translocation of substrate across membrane
interaction 
regulation 
topologytransmembrane domains: 5 (potential)

TMHMM gives 15-37 46-68 83-105 155-174 189-211
SP gives 16-36 42-62 80-100 155-175 187-207

mfeylpelmk glhtSLTLTV ASLIVALILA LIFTIILtlk tpvlvWLVRG
YITLFTGTPL LVQIFLIYyg pgqfptlqey paLWHLLSEP WLCALIALSL
NSAAYttqlf ygairaipeg qwqscsalgm skkdtlaill pyafkrslss
ysneVVLVFK STSLAYTITL MEVMgysqll ygrtydvmVF GAAGIIYLVV 200
NGLLTLMMRL Ierkalafer rn

MW24913Da; 222 aa


Arginine transport system permease protein ArtQ (artQ )
functionpart of binding-protein dependent transport system for arginine, probably responsible for translocation of substrate across membrane
interaction 
regulation 
topologytransmembrane domains:4 (potential)

TMHMM gives 10-32 45-67 101-118 201-223
SP gives 15-35 49-69 99-119 202-222

mneffplasA AGMTVGLAVC ALIVGLALAM FFavwesakw rpvaWAGSAL
VTILRGLPEI LVVLFIYfgs sqllltlsdg ftinlgfvqi pvqmdienfd
VSPFLCGVIA LSLLYAAYas qtlrgalkav pvgqwesgqa lglsksaiff
rlvmpqmwrh alpglgnqwl vllkdtalvs lisvndlmlq tksiatrtqe 200
PFTWYIVAAA IYLVITLLSQ YILkridlra trferrps

MW26217Da; 238 aa


Branched-chain amino acid transport system II carrier protein (brnQ )
functioncomponent of the Liv-II transport system for branched amino acids, may be H+-coupled
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 13-35 41-63 76-98 118-140 147-169 189-211 223-245 276-298 305-327 337-359 371-393 408-426
SP gives 10-30 46-66 80-100 119-139 150-170 190-210 227-247 278-298 317-337 339-359 370-390 405-425

mthqlrsrdi iaLGFMTFAL FVGAGNIIFP PMVGLqageh VWTAAFGFLI
TAVGLPVLTV VALakvgggv dslstPIGKV AGVLLATVCY LAVGPLFAtp
rtatvsfevg iapltgdSAL PLFIYSLVYF AIVILVSLYP gklldtVGNF
LAPLKIIALV ILSVAAIVWp agsistatea yqnaafsnGF VNGYLTMDTL 200
GAMVFGIVIV Naarsrgvte arLLTRYTVW AGLMAGVGLT LLYLAlfrlg
sdsaslvdqs angaailhay vqhtfGGGGS FLLAALIFIA CLVTAVGLtc
acaeFFAQYV PLSYRTLVFI LGGFSMVvsn lglsqlIQIS VPVLTAIYPP

CIALVVLSFt rswwhnssrv IAPPMFISLL FGILDGIKAS AFSdilpswa 400
qrlplaeQGL AWLMPTVVMV VLAIIWdraa grqvtssah

MW46208Da; 439 aa


D-serine/D-alanine/glycine transporter (cycA )
functionpermease that is involved in the transport across the membrane
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 27-44 49-71 104-126 136-158 165-187 210-232 252-274 289-311 342-364 374-396 417-435 439-461
SP gives 30-50 51-71 102-122 137-157 162-182 211-231 256-276 283-303 350-370 371-391 413-433 441-461

mvdqvkvvad dqapaeqslr rnltnrHIQL IAIGGAIGTG LFMGsgktIS
LAGPSIIFVY MIIGFMLFFV Mramgellls nleyksfsdf asdllgpwag
yftGWTYWFC WVVTGMADVV AITAYAqfwf pdlsdWVASL AVIVLLLTLN
LATVKMFGem efwfAMIKIV AIVSLIVVGL VMVAMHFqsp tgveasfahl 200
wndggwfpkG LSGFFAGFQI AVFAFVGIEL VGttaaetkd pekslprain
sIPIRIIMFY VFALIVIMSV TPWSsvvpek spfvelfvLV GLPAAASVIN
FVVLTSAASS Ansgvfstsr mlfglaqegv apkafaklsk rAVPAKGLTF
SCICLLGGVV MLYVnpsvig aftMITTVSA ILFMFVWTII LCSYLVyrkq 400
rphlheksiy kmplgkLMCW VCMAFFVFVV VLLTLeddTR QALLVTPLWF
IALGLGWLFI Gkkraaelrk

MW51659Da; 470 aa


GABA permease (gabP )
functiontransporter for gamma aminobutyrate
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 19-41 46-65 86-108 123-145 152-174 202-224 245-267 287-309 335-357 362-381 401-423 427-449
SP gives 21-41 42-62 97-117 119-139 154-174 200-220 247-267 287-307 335-355 360-380 403-423 429-449

mgqssqphel ggglksrhVT MLSIAGVIGA SLFVGSSVAI AeagpAVLLA
YLFAGLLVVM IMRMLaemav atpdtgsfst yadkaIGRWA GYTIGWLYWW
FWVLVIPLea niaamilhsw vpGIPIWLFS LVITLALTGS NLLSVknyge
fEFWLALCKV IAILAFIFLG AVAIsgfypy aevsgisrlw dsggfmpngf 200
gAVLSAMLIT MFSFMGAEIV TIAAaesdtp ekhivratns viwrISIFYL
CSIFVVVALI PWNMPGLkav gsyrsvlell niphakLIMD CVILLSVTSC
LNSALYTASr mlyslsrrgd apavmgkinr sktpYVAVLL STGAAFLTVV
VNYYAPAkvf kFLIDSSGAI ALLVYLVIAV Sqlrmrkilr aegseirlrm 400
WLYPWLTWLV IGFITFVLVV MLFrpaQQLE VISTGLLAIG IICTVPIMAr
wkklvlwqkt pvhntr

MW51080Da; 466 aa


Glutamine transport system permease protein GlnP (glnP )
functionpart of binding protein dependent transport system for glutamine, probably responsible for translocation of the substrate across the membrane
interaction 
regulationinduction: lack of glutamine
topologytransmembrane domains: 3 (potential)

TMHMM gives 20-42 54-76 187-209
SP gives 23-43 54-74 89-109 151-171 188-208

mqfdwsaiwp aiplliegaK MTLWISVLGL AGGLVIGLLA GFartfggwi
anhVALVFIE VIRGTPIVVQ VMFIYFalpm afndlridpf taavvtimin
sgayiaeitr gavlsihkgf reaglalgls rwetiryvil plalrrmlpp
lgnqwiisik dtslfivigv aeltrqgqei iagnfrALEI WSAVAVFYLI 200
ITLVLSFILr rlerrmkil

MW24364 Da; 219 aa


Glutamate/aspartate transport system permease protein GltJ (gltJ )
functionpart of binding protein dependent transport system for aspartat/glutamate, probably responsible for translocation of the substrate across the membrane
interaction 
regulation 
topologytransmembrane domains: 5 (potential)

TMHMM gives 31-53 66-88 108-127 179-196 211-233
SP gives 33-53 74-94 104-124 212-232

msidwnwgif lqqapfgntt ylgwiwsgfq VTIALSICAW IIAFLVGSFF
GILrtvpnrf lsglgTLYVE LFRNVPLIVQ FFTWYLVIpe llpekigmwf
kaeldpnIQF FLSSMLCLGL FTAARVCeqv raaiqslprg qknaalamgl
tlpqayryvl lpnayrvivp pmtsemmnLV KNSAIASTIG LVDMAAqagk 200
lldysahawe SFTAITLAYV LINAFIMLVM TLVerkvrlp gnmggk

MW27502Da; 246 aa


Glutamate/aspartate transport system permease protein GltK (gltK )
functionpart of binding protein dependent transport system for aspartat/glutamate, probably responsible for translocation of the substrate across the membrane
interaction 
regulation 
topologytransmembrane domains: 5 (potential)

TMHMM gives 15-37 58-80 95-112 155-177 197-219
SP gives 20-40 68-88 131-151 155-175 197-217

myefdwssiv pslpYLLDGL VITLKITVTA VVIGILWgtm lavmrlssfa
pvawfakAYV NVFRSIPLVM VLLWFYLIVP gflqnvlgls pkndIRLISA
MVAFSMFEAA YYseiiragi qsisrgqssa alalgmthwq smkliilpqa
framVPLLLT QGIVLFQDTS LVYVLSLadf frtastiger dgtqveMILF 200
AGFVYFVISL SASLLVSYLk rrta

MW24914 Da; 224 aa


Probable 3-phenylpropionic acid transporter HcaT (hcaT/yfhS )
functionProbable 3-phenylpropionic acid permease
interaction 
regulation 
topologytransmembrane domains: 12 (potential), SP has 10

TMHMM gives 9-31 41-63 70-89 93-111 132-154 158-180 207-229 234-256 269-288 293-315 328-350 354-371
SP gives 11-31 41-61 81-101 134-154 156-176 207-227 236-256 281-301 329-349 351-371

mvlqstrWLA LGYFTYFFSY GIFLPFWSVW Lkgigltpet IGLLLGAGLV
ARFLGSLLIA prvsdpsrLI SALRVLALLT LLFAVAFWAg ahVAWLMLVM
IGFNLFFSPL Vpltdalant wqkqfpldyg kvrLWGSVAF VIGSALTGKL
VTMFdyrVIL ALLTLGVASM LLGFLIRPTI qpqgasrqqe stgwsawlal 200
vrqnwrFLAC VCLLQGAHAA YYGFSAIYWq aagYSASAVG YLWSLGVVAE
VIIFALsnkl frrcsardML LISAICGVVR WGIMGATTal pWLIVVQILH
CGTFTVCHLA AMRYIaarqg sevirlqAVY SAVAMGGSIA IMTVFAGFLY
qylGHGVFWV MALVALPAMF Lrpkvvpsc

MW41592 Da; 379 aa


Histidine transport system permease protein HisM (hisM )
functionpart of binding protein dependent transport system for histidine, probably responsible for translocation of the substrate across the membrane
interaction 
regulation 
topologytransmembrane domains: 5

TMHMM gives 25-47 57-79 167-189 199-221
SP gives 27-47 59-79 105-125 158-178 201-221

mieilheywk pllwtdgyrf tgvaITLWLL ILSVVIGGVL ALFLAIGrvs
snkyiqFPIW LFTYIFRGTP LYVQLLVFYs gmytleivkg teflnaffrs
glncTVLALT LNTCAYTTEI FAGAIrsvph geieaarayg fstfkmyrci
ilpsalrIAL PAYSNEVILM LHSTALAFta tvpdllkiar dinaatyqpF 200
TAFGIAAVLY LIISYVLISL Frraekrwlq hvkpssth

MW26869Da; 238 aa


Histidine transport system permease protein HisQ (hisQ )
functionpart of binding protein dependent transport system for histidine, probably responsible for translocation of the substrate across the membrane
interaction 
regulation 
topologytransmembrane domains: 5

TMHMM gives 15-37 58-80 90-108 149-171 191-213
SP gives 13-33 59-79 88-108 153-173 195-215

mlygfsgvil qgalVTLELA ISSVVLAVII GLIGAGGkls qnrlsglife
gyttlirGVP DLVLMLLIFY GLQIALNTVT eamgvgqidI DPMVAGIITL
GFIYGAYFte tfrgafmavp kghieaataf gftrgqvfrr imfpsmmrYA
LPGIGNNWQV ILKSTALVSL Lgledvvkat qlagkstwep FYFAIVCGVI 200
YLVFTTVSNG VLLflerrys vgvkradl

MW24649 Da; 228 aa


High-affinity branched chain amino acid transport permease protein LivH (livH )
functionpart of binding protein dependent transport system for branched chain amino acids, probably responsible for translocation of the substrate across the membrane
interaction 
regulation 
topologytransmembrane domains: 8 (potential)

TMHMM gives 15-37 44-66 70-92 105-124 153-175 207-229 244-266 282-301
SP gives 22-42 46-66 69-89 105-125 155-175 204-224 246-266 281-301

mseqflyflq qmfnGVTLGS TYALIAIGYT MVYGIIGmin fahGEVYMIG
SYVSFMIIAA LMMMGIdtgW LLVAAGFVGA IVIASAYGWS IErvayrpvr
nskrLIALIS AIGMSIFLQN YVSLtegsrd valpslfngq wvvghsenfs
asITTMQAVI WIVTFLAMLA LTIFIrysrm gracracaed lkmasllgin 200
tdrviaLTFV IGAAMAAVAG VLLGQFYGVi npyigfmagm kafTAAVLGG
IGGIPGAMIG GLILGIaeal ssaylsteyk dVVSFALPIL VLLVMPTGIL
Grpevekv

MW32936Da; 308 aa


High-affinity branched chain amino acid transport permease protein LivM (livM )
functionpart of binding protein dependent transport system for branched chain amino acids, probably responsible for translocation of the substrate across the membrane
interaction 
regulation 
topologytransmembrane domains: 10 (potential)

TMHMM gives 4-26 47-66 91-108 120-142 162-184 193-210 261-283 315-337 352-374 381-400
SP gives 6-26 45-65 92-112 120-140 145-165 167-187 191-211 260-280 311-331 353-373 387-407

mkpMHIAMAL LSAAMFFVLA GVFMGVqlel dgtklvvdta sdvrwqWVFI
GTAVVFFFQL LRPAFQkglk svsgpkfilp aidgstvkqk LFLVALLVLA
VAWPFMVSrg tvdiatltmI YIILGLGLNV VVGLSGLLVL GYggfyaiga
ytfallnhyy gLGFWTCLPI AGLMAAAAGF LLGFpvlrlr gdYLAIVTLG 200
FGEIVRILLL nnteitggpn gisqipkptl fglefsrtar eggwdtfsnf
fglkydpsdr VIFLYLVALL LVVLSLFVIN RLLrmplgra wealredeia
crslglsprr ikltAFTISA AFAGFAGTLF AARQGFVspe sftfaesafv
lAIVVLGGMG SQFAVILAAI LLVVsrelmr DFNEYSMLML GGLMVLMMIW 400
rpqgllpmtr pqlklkngaa kgeqa

MW46269 Da; 425 aa


Lysine specific permease (lysP )
functionpermease, that is involved in thetransport of lysine across the cytoplasmic membrane
interaction 
regulationinduction: high in anaerobic media of low pH, containing lysine
topologytransmembrane domains: 12

TMHMM gives 20-42 52-74 102-124 129-151 158-180 195-217 244-266 286-308 342-364 369-391 412-434 444-466
SP gives 21-41 55-75 104-124 130-148 160-180 199-217 244-263 283-303 347-364 371-391 415-432 449-469

vsetktteap glrrelkarH LTMIAIGGSI GTGLFVASGA TIsqagpgga
lLSYMLIGLM VYFLMTSLGE LAAYmpvsgs fatygqnyve egfgfalgwn
yWYNWAVTIA VDLVAAQLVM NWWFpdtpGW IWSALFLGVI FLLNYISVRG
FgeaeywFSL IKVTTVIVFI IVGVLMIIGI fkgaqpagws nwtiGEAPFA 200
GGFAAMIGVA MIVGFSFqgt eligiaages edpaknipra vrqVFWRILL
FYVFAILIIS LIIPYTdpsl lrndvkdisv spftlVFQHA GLLSAAAVMN
AVILTAVLsa gnsgmyastr mlytlacdgk aprifaklsr gGVPRNALYA
TTVIAGLCFL TSMFgnqtVY LWLLNTSGMT GFIAWLGIAI Shyrfrrgyv 400
lqghdindlp yRSGFFPLGP IFAFILCLII TLGQnyeafl kdtIDWGGVA
ATYIGIPLFL IIWFGYklik gthfvrysem kfpqndkk

MW53471 Da; 488 aa


Tryptophan specific transport protein (mtr )
functioninvolved in transport of tryptophan across the cytoplasmic membrane
interaction 
regulationinduction: by phenylalanin under the control of regulatory protein TyrR
topologytransmembrane domains: 12 (potential)

TMHMM gives 13-35 39-61 87-109 124-146 153-175 190-212 225-247 284-306 318-340 345-367 388-410
SP gives 16-36 42-62 89-109 129-149 152-172 191-211 229-249 256-276 286-306 326-346 347-367 387-407

matltttqts psLLGGVVII GGTIIGAGMF SLPVVmsgAW FFWSMAALIF
TWFCMLHSGL Mileanlnyr igssfdtitk dllgkgWNVV NGISIAFVLY
ILTYAYISAs gsilhhtfae mslNVPARAA GFGFALLVAF VVWLSTkavs
rmTAIVLGAK VITFFLTFGS LLGHVqpatl fnvaesnasY APYLLMTLPF 200
CLASFGYHGN VPslmkyygk dpktIVKCLV YGTLMALALY TIWLLATmgn
iprpeFIGIA EKGGNIDVLV QALSGVLnsr sldLLLVVFS NFAVASSFLG
VTLGLFdyla dlfgfddSAV GRLKTALLTF APPVVGGLLF pngfLYAIGY
AGLAATIWAA IVPALLAras rkrfgspkfr vwggkpmIAL ILVFGVGNAL 400
VHILSSFNLL pvyq

MW44332 Da; 414 aa


Phenylalanin-specific permease (pheP )
functionpermease that is involved in the transport of phenylalanin across the cytoplasmic memebrane
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 30-49 53-70 98-120 135-157 162-184 206-228 249-271 291-313 340-362 366-388 408-430 435-452
SP gives 28-48 51-71 106-126 133-153 161-181 197-217 251-271 289-309 342-362 368-388 412-432 435-455

mknastvsed tasnqeptlh rglhnrhiqL IALGGAIGTG LFLGIGPAIq
maGPAVLLGY GVAGIIAFLI mrqlgemvve epvsgsfahf aykywgpFAG
FLSGWNYWVM FVLVGMAELT aagiymqywf pdvpTWIWAA AFFIIINAVN
LVNVRLYget eFWFALIKVL AIIGMIGFGL WLLFsghgge kasidnlwry 200
ggffaTGWNG LILSLAVIMF SFGGLELIgi taaeardpek sipkavnqVV
YRILLFYIGS LVVLLALYPW Vevksnsspf vmifhnldsn VVASALNFVI
LVASLSVYNS GVYsnsrmlf glsvqgnapk fltrvsrrgV PINSLMLSGA
ITSLVVLINY LLpqkAFGLL MALVVATLLL NWIMICLAhl rfraamrrqg 400
retqfkaLLY PFGNYLCIAF LGMILLLMCT mddmRLSAIL LPVWIVFLFM
AFktlrrk

MW50677 Da; 458 aa


Glycine-betaine/L-proline transport system permease protein ProW (proW )
functioninvolved in a multicomponent binding- protein-dependent transport system for glycine-betaine/L-proline
interaction 
regulation 
 transmembrane domains: 7

TMHMM gives 94-116 120-142 149-171 197-219 272-294 298-320
SP gives 100-116 123-142 149-171 189-205 212-230 272-290 304-320

madqnnpwdt tpaadsaaqs adawgtptta ptdgggadwl tstpapnveh
fnildpfhkt lipldswvte gidwvvthfr pvfqgvrvpv dyiLNGFQQL
LLGMPAPVAI IVFALIawqI SGVGMGVATL VSLIAIGAIG AWsqamvtLA
LVLTALLFCI VIGLPLGIWL Arspraakii rplldaMQTT PAFVYLVPIV 200
MLFgignvpg VVVTIIFALP PIIRLTILGI nqvpadliea srsfgasprq
mlfkvqlpla mptimagvnq tLMLALSMVV IASMIAVGGL GQMVlrgIGR
LDMGLATVGG VGIVILAIIL drltqavgrd srsrgnrrwy ttgpvglltr
pfik

MW37619 Da; 354 aa


Proline-specific permease (proY )
functionpermease that is involved in the transport of proline across the cytoplasmic membrane
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 16-34 44-63 83-105 120-142 154-176 196-218 239-261 276-298 329-351 356-378 399-421 426-445
SP gives 18-38 39-59 85-105 114-134 135-155 157-177 198-218 243-263 278-298 332-352 356-376 400-420 425-445

mesknklkrg lstrhIRFMA LGSAIGTGLF YGSAdaikma gpsVLLAYII
GGIAAYIIMR ALGemsvhnp aassfsryaq enLGPLAGYI TGWTYCFEIL
IVAIAdvtaf giymgvwfpT VPHWIWVLSV VLIICAVNLM SVkvfgelef
wfsFFKVATI IIMIVAGFGI IIWGIGnggq ptgihnlwsn ggffsNGWLG 200
MVMSLQMVMF AYGGIEIIgi tageakdpek siprainsVP MRILVFYVGT
LFVIMSIYPW Nqvgtagspf vltfqHMGIT FAASILNFVV LTASLSAIns
dvfgvgrmlh gmaeqgsapk ifsktsrrGI PWVTVLVMTT ALLFAVYLNY
ImpenVFLVI ASLATFATVW VWIMILLSqi afrrrlppee vkalkfkvPG 400
GVATTIGGLI FLLFIIGLIG YhpdtRISLY VGFAWIVVLL IGWMFkrrhd
rqlaenq

MW50215 Da; 457 aa


Serine transporter (sdaC )
functioninvolved in the import of serine into the cell
interaction 
regulationinduction: by leucine and growth in rich medium
topologytransmembrane domains: 11 (potential)

TMHMM gives 24-41 45-67 103-125 140-157 164-186 206-228 249-271 300-322 351-373 377-394 406-428
SP gives 23-43 47-67 100-120 141-161 164-184 202-222 250-270 298-318 348-368 370-390 407-427

mettqtstia skdsrsawrk tdtMWMLGLY GTAIGAGVLF LpinAGVGGM
IPLIIMAILA FPMTFFAhrg ltrfvlsgkn pgeditevve ehfgigagkl
itLLYFFAIY PILLVYSVAI TNTVEsfmsh qlgmtppprA ILSLILIVGM
MTIVRFGeqm ivkAMSILVF PFVGVLMLLA LYLIPQwnga aletlsldta 200
satgnGLWMT LWLAIPVMVF SFNHSPIIss favakreeyg dmaeqkcsKI
LAFAHIMMVL TVMFFVFSCV Lsltpadlaa akeqnisils ylanhfnapV
IAWMAPIIAI IAITKSFLGH YLgaregfng mvikslrgkg ksieinklnr
ITALFMLVTT WIVATLNPSI LGMietLGGP IIAMILFLMP MYAIqkvpam 400
rkysgHISNV FVVVMGLIAI SAIFYSLFs

MW46906 Da; 429 aa


Low affinity tryptophan permease (tnaB )
functioninvolved in the transport of tryptophan across the cytoplasmic membrane
interaction 
regulationinduction: by tryptophane, subject to catabolite repression
topologytransmembrane domains: 11 (potential)

TMHMM gives 12-34 39-61 82-104 124-146 153-175 195-217 230-252 285-307 320-342 347-369 382-404
SP gives 12-32 34-54 87-107 128-148 154-174 192-212 230-250 287-307 327-347 349-369 388-408

mtdqaekkhs aFWGVMVIAG TVIGGGMFAL PVDLagawFF WGAFILIIAW
FSMLHSGLLL Leanlnypvg ssfntitkdl iGNTWNIISG ITVAFVLYIL
TYAYisanga iisetismnl gyhANPRIVG ICTAIFVASV LWLSSLaasr
itSLFLGLKI ISFVIVFGSF FFQVDysilr datsstagts yfpyIFMALP 200
VCLASFGFHG NIPSLIIcyg krkdkliksV VFGSLLALVI YLFWLYCTMG
NIpresfkai issggnvdsl vksflgtkqh giieFCLLVF SNLAVASSFF
GVTLGLFdyl adlfkidnsH GGRFKTVLLT FLPPALLYLI FPngfiYGIG
GAGLCATIWA VIIPAVLAIk arkkfpnqmf tVWGGNLIPA IVILFGITVI 400
LCWFgnvfnv lpkfg

MW45210 Da; 415 aa


Tyrosine-specific transport protein (tyrP )
functioninvolved in transporting tyrosine across the cytoplasmic membrane
interaction 
regulationrepressed by tyrosine and induced by phenylalanine, under the control of regulatory protein TyrR
topologytransmembrane domains: 11 (potential)

TMHMM gives 7-29 33-55 78-100 115-137 144-166 181-203 216-238 273-295 308-330 335-357 377-399
SP gives 9-29 35-55 81-101 122-142 148-168 184-204 217-237 275-295 308-328 332-352 376-396

mknrtlGSVF IVAGTTIGAG MLAMPLAAAg vgFSVTLILL IGLWALMCYT
ALLLLevyqh vpadtglgtl akrylgrYGQ WLTGFSMMFL MYALTAAYIS
gagellassi sdwtGISMSA TAGVLLFTFV AGGVVCVgts lvdLFNRFLF
SAKIIFLVVM LVLLLPhihk vnlltlplqq GLALSAIPVI FTSFGFHGSV 200
PSIvsymdgn irklrWVFII GSAIPLVAYI FWQVATLGsi dsttfmglla
nhaglngllq alremvasph veLAVHLFAD LALATSFLGV ALGLFdylad
lfqrsntVGG RLQTGAITFL PPLAFALFYP rgfvMALGYA GVALAVLALI
IPSLLTWqsr khnpqagyrv kggrpaLVVV FLCGIAVIGV QFLIAAGLLp 400
evg

MW42819 Da; 403 aa


Uracil permease (uraA )
function 
interactiontransport of uracil in the cell
regulation 
topologytransmembrane domains: 12 (potential), SP has 11

TMHMM gives 13-35 39-61 68-85 89-108 121-143 158-180 185-207 227-249 304-326 331-353 365-387 392-411
SP gives 29-49 65-85 88-108 127-147 159-179 182-202 228-248 300-320 325-345 366-386 392-412

mtrraigvse rpPLLQTIPL SLQHLFAMFG ATVLVpvlFH INPATVLLFN
GIGTLLYLFI CkgkipaYLG SSFAFISPVL LLLPLgyeVA LGGFIMCGVL
FCLVSFIVkk agtgwldvlf PPAAMGAIVA VIGLELAGVA AGMagllpae
gqtpdskTII ISITTLAVTV LGSVLFRGFL aiipILIGVL VGYALSFAMG 200
IVDTTPIina hwfalptlyt prfewfAILT ILPAALVVIA EHVGHLVVTa
nivkkdllrd pglhrsmfan glstvisgff gstpnttyge nigvmaitrv
ystWVIGGAA IFAILLSCVG KLAAAIqmip LPVMGGVSLL LYGVIGASGI
RVLieskvdy nkaqNLILTS VILIIGVSGA KVNIGAAelk gMALATIVGI 400
GLSLIFKLIS Vlrpeevvld aedaditdk

MW45060 Da; 429 aa


Amino Acid Antiporters

Probable cadaverine/lysine antiporter (cadB )
functionantiporter, or part of antiporter
interaction 
regulationinduction: at low pH in the presence of lysine, achieves maximum level under anaerobic conditions
topologytransmembrane domains: 12 (potential), SP has 14

TMHMM gives 7-29 39-58 93-115 120-142 149-171 186-208 220-242 271-293 322-344 354-371 384-403 407-424
SP gives 7-27 35-55 68-88 95-115 123-143 149-169 193-213 222-242 250-270 273-293 323-343 354-374 384-404 405-425

mssakkIGLF ACTGVVAGNM MGSGIALLPa nlasiggiAI WGWIISIIGA
MSLAYVYArl atknpqqggp iayageispa fgfqtgvlyy haNWIGNLAI
GITAVSYLST FFPVLndpvP AGIACIAIVW VFTFVNMLGG TWvsrlttIG
LVLVLIPVVM TAIVGWHWFD Aatyaanwnt adttdGHAII KSILLCLWAF 200
VGVESAAVst gmvknpkrtV PLATMLGTGL AGIVYIAATQ VLsgmypssv
maasgapfai sastilgnwa APLVSAFTAF ACLTSLGSWM MLVgqagvra
andgnfpkvy gevdsngipk kGLLLAAVKM TALMILITLM NSAGgkasdl
fgeLTGIAVL LTMLPYFYSC Vdlirfegvn irnFVSLICS VLGCVFCFIA 400
LMGassFELA GTFIVSLIIL MFYArkmher qshsmdnhta snah

MW46665 Da; 444 aa


Putrescine-ornithine antiporter (potE )
function 
interaction 
regulationinduction: by low environmental pH
topologytransmembrane domains: 12 (potential)

TMHMM gives 9-31 37-59 89-111 121-143 150-172 187-206 227-249 269-291 323-342 352-374 387-405 410-429
SP gives 11-31 38-58 90-110 117-137 152-172 186-206 224-244 277-297 325-345 352-372 387-407 410-430

msqaksnkMG VVQLTILTMV NMMGSGIIML PtklaeVGTI SIISWLVTAV
GSMALAWAFa kcgmfsrksg gmggyaeyaf gksgnfmaNY TYGVSLLIAN
VAIAISAVGY Gtellgasls PVQIGLATIG VLWICTVANF GGAritgqiS
SITVWGVIIP VVGLCIIGWF WFsptlyvds wnphhaPFFS AVGSSIAMTL 200
WAFLGLesac antdvvenpe rnvpiaVLGG TLGAAVIYIV STNVIAGIVp
nmelanstap fglafaqmFT PEVGKVIMAL MVMSCCGSLL Gwqftiaqvf
ksssdegyfp kifsrvtkvd apVQGMLTIV IIQSGLALMT ISpslnsqfn
vLVNLAVVTN IIPYILSMAA LVIIqkvanv ppskakVANF VAFVGAMYSF 400
YALYSsgeeA MLYGSIVTFL GWTLYGLVSp rfelknkhg

MW46495 Da; 439 aa


Amino acid antiporter (xasA )
functionprobable amino acid antiporter, involved in extreme acid resistance
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 13-30 40-62 95-117 132-151 158-180 195-217 238-260 288-310 335-357 372-394 407-429 444-466
SP gives 15-35 42-62 94-114 128-148 158-178 201-221 240-260 292-312 336-356 367-387 413-433 446-466

matsvqtgka kqLTLLGFFA ITASMVMAVY eyptfatsgF SLVFFLLLGG
ILWFIPVGLC AAematvdgw eeggvfawvs ntlgprwgfa aisfGYLQIA
IGFIPMLYFV LGALSYIlkw palnedpitk tIAALIILWA LALTQFGGTK
YtariakVGF FAGILLPAFI LIALAAIYLH sgapvaiemd sktfFPDFSK 200
VGTLVVFVAF ILSYMGVeas athvnemsnp grdyplaMLL LMVAAICLSS
VGGLSIAMVI pgneinlsag vmqtftvlms hvapeieWTV RVISALLLLG
VLAEIASWIV gpsrgmyvta qknllpaafa kmnkNGVPVT LVISQLVITS
IALIILTntg ggnnmsflia lALTVVIYLC AYFMLFIGYI VLVLkhpdlk 400
rtfnipGGKG VKLVVAIVGL LTSIMAFIVs flppdniqgd stdMYVELLV
VSFLVVLALP FILYAVhdrk gkantgvtle pinsqnapkg hfflhprars
phyivmndkk h

MW55076 Da; 511 aa


Amino Acid Symporters

Proline/betaine transporter (proP )
functionstrech inactivated proline/betaine transporter. ProP is both an osmosensor and an osmoregulator which is available to participate early in bacterial osmoregulation
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 30-52 67-89 98-117 121-143 168-190 200-217 260-282 297-319 326-346 351-373 386-408 418-437
SP gives 41-57 62-78 98-114 122-137 173-189 202-218 261-277 298-314 330-346 349-365 395-411 417-433

mlkrkkvkpi tlrdvtiidd gklrkaitaA SLGNAMEWFD FGVYGFVAYA
LGkvffpgad psvqmvAALA TFSVPFLIRP LGGLFFGMLg dkygrqkILA
ITIVIMSIST FCIGLIPsyd TIGIWAPILL LICKMAQGFS VGGeytgasi
fvaeyspdrk rgfmgswLDF GSIAGFVLGA GVVVLISTIV geanfldwgW 200
RIPFFIALPL GIIGLYLrha leetpafqqh vdkleqgdre glqdgpkvsf
keiatkywrS LLTCIGLVIA TNVTYYMLLT YMpsylshnl hysedhGVLI
IIAIMIGMLF VQPVMGLLSd rfgrrPFVLL GSVALFVLAI PAFILInsnv
IGLIFAGLLM LAVILNCFTG VMAstlpamf pthirYSALA AAFNISVLVA 400
GLTPTLAAwl vessqnlMMP AYYLMVVAVV GLITGVTmke tanrplkgat
paasdiqeak eilvehydni eqkiddidhe iadlqakrtr lvqqhpride

MW54845 Da; 500 aa


Sodium/proline symporter (putP )
functioncatalyzes the sodium-dependent uptake of extracellular L-proline, this protein is also able of using lithium as the transport cation
interaction 
regulation 
topologytransmembrane domains: 12 (potential)

TMHMM gives 7-26 66-88 125-147 162-184 191-213 233-255 275-297 329-351 372-391 401-423 428-450 455-473
SP gives 4-26 67-87 125-150 163-184 190-213 232-248 275-295 320-340 371-391 398-423 431-445 449-475

maistpMLVT FCVYIFGMIL IGFIAWrstk nfddyilggr slgpfvtals
agasdmsgwl lmglpGAVFL SGISESWIAI GLTLGAWInw klvagrlrvh
teynnnaltl pdyftgrfed ksriLRIISA LVILLFFTIY CASGIVAgar
lfestfgmsy eTALWAGAAA TILYTFIGGF LAVSwtdtvq ASLMIFALIL 200
TPVIVIISVG GFGdslevik qksienvdml kgLNFVAIIS LMGWGLGYFG
QPHILarfma adshhsivha rrisMTWMIL CLAGAVAVGF FGIAYFNdhp
alagavnqna ervfielaqi lfnpwiagIL LSAILAAVMS TLSCQLLVCS
Saitedlyka flrkhasqke lVWVGRVMVL VVALVAIALA Anpenrvlgl 400
VSYAWAGFGA AFGPVVLFSV MWSrmtrNGA LAGMIIGALT VIVWKQFGWL
glyeIIPGFI FGSIGIVVFS LLGkapsaam qkrfaeadah yhsappsrlq
es

MW54344 Da; 502 aa


Threonine/serine transporter (tdcC )
functioninvolved in the import of threonine and serine into the cell, uses hydrogen cation for cotransport
interaction 
regulation 
topologytransmembrane domains: 11 (potential)

TMHMM gives 23-40 44-66 97-119 134-156 163-185 212-234 255-277 311-333 358-380 390-409 422-440
SP gives 22-42 44-64 97-117 140-160 163-183 207-227 261-281 311-331 366-386 389-409 423-443

mstsdsivss qtkqsswrks dtTWTLGLFG TAIGAGVLFF pirAGFGGLI
PILLMLVLAY PIAFYChral arlclsgsnp sgnitetvee hfgktgGVVI
TFLYFFAICP LLWIYGVTIt ntfmtfwenq lgfAPLNRGF VALFLLLLMA
FVIWFGkdlm vkVMSYLVWP FIASLVLISL SLIPYwnsav idqvdlgsls 200
ltghdgilit vWLGISIMVF SFNFSPIVSS FVVSkreeye kdfgrdfter
kcsqIISRAS MLMVAVVMFF AFSCLFTlsp anmaeakaqn ipvlsylanh
fasmtgtktt FAITLEYAAS IIALVAIFKS FFGhylgtle glnglvlkfg
ykgdktkVSL GKLNTISMIF IMGSTWVVAY anpnildliE AMGAPIIASL 400
LCLLPMYAIr kapslakyrg rLDNVFVTVI GLLTILNIVY klf

MW48879 Da; 443 aa


Efflux Systems for Amino Acids

Threonine efflux protein RhtC (rhtC/yigJ )
function 
interaction 
regulation 
topologytransmembrane domains: 6 (potential), SP has 4

TMHMM gives 5-27 40-62 67-86 119-141 151-173 186-205
SP gives 1-21 44-64 67-87 150-173

mlmlFLTVAM VHIVALMSPG PDFFFVSqta vsrsrkeamM GVLGITCGVM
VWAGIALLGL HLiiekMAWL HTLIMVGGGL YLCWMGyqml rgalkkeavs
apapqvelak sgrsflkgLL TNLANPKAII YFGSVFSLFV Gdnvgttarw
GIFALIIVET LAWFTVVASL FALpqmrrgy qrlakWIDGF AGALFAGFGI 200
HLIISr

MW22474 Da; 206 aa