The Brain Repair Group
The 'StemStroke' Project
Functional repair of the ischaemic striatum and cortex with primary and stem cell grafts
Goals
To validate new strategies to differentiate stem cells into appropriate neuronal lineages for implantation into the ischaemic brain.
To achieve this functional goal a number of interim goals have to be solved in sub-programmes:
· to refine stem cell differentiation protocols;
· to develop new methods for labelling and tracking cells after implantation in vivo;
· to develop novel strategies to recruit endogenous stem cells to target repair;
· to validate new assessment protocols to determine the functional progress of experimental subjects after ischaemia and cellular repair;
· to develop the protocols for cell preparation, handling and implantation under ‘GMP’ to prepare for clinical applications.
The StemStroke Project
The StemStroke project involves academic and commercial partners from the UK, Sweden, Germany and Italy:
| Short Name | Organisation | Team Leader | Location |
| ULUND | University of Lund | Z. Kokaia | Lund, Sweden |
| UCAM-STEM | Cambridge University | A. Smith | Cambridge, UK |
| MPI | Max-Planck-Inst | M. Hoehn | Köln, Germany |
| EMBL | Eur. Mol. Biol. Lab | L. Minichiello | Monterotondo, Italy |
| CU | Cardiff University | S. Dunnett | Cardiff, UK |
| Neuronova | NeuroNova AB | L. Wikström | Stockholm, Sweden |
Details of the project may be found on the StemStroke
website
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