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The Brain Repair Group:

Current Grant Funding

2009 Wellcome Trust summer studentship (A Jones, E Lane & SB Dunnett) 089766/z/09/z. Determining the relevance of dopamine cell phenotype to amphetamine-induced abnormal involuntary movements in parkinsonism with intrastriatal transplants. £1440.
2009 EU FP7 collaborative research programme HEALTH-2009-1.4-1 (RA Barker, SB Dunnett and others) HEALTH-F5-2008-222943. TRANSEURO: Neural transplantation in the treatment of patients with Parkinson’s disease. €1,180,414 (£873,507) over 4 years from 1 Jan 2010.
2009 Parkinson’s Disease Society, Cangen Arfon & Mon branch. (SB Dunnett). Research equipment donation. £5,000 for blood gas analyser
2009 Welsh Office for Research & Development (WORD) Translational Health Research Platform programme. (SB Dunnett & AE Rosser). TRP08-007. Quality-assured human tissues for clinical trials of novel cell transplantation therapies in Wales. £249,934 over 3 years from 1 April 2009.
2009 Parkinson’s Disease Society, Seed funding grant (SB Dunnett, EL Lane & S Paisey) Scanning changes in functional brain activity associated with dyskinesia in parkinsonian rats. £14,978 over 1 year from 1 Jan 2009.
   
2008 Parkinson’s Disease Society, South Powys branch. (SB Dunnett). Personal equipment donation by Mrs Stearne in memory of Mr John Stearne. £1,022 for rotary shaker
2008 Parkinson’s Disease Society, Cardiff branch. Donation for laboratory research equipment. £2,904, October 2008.
2008 Parkinson’s Disease Society, Bridgend branch. Donation for laboratory research equipment. £2,000, raised by Alun Morgan, July 2008
2008 Eli Lilly / BBSRC CASE studentship (S.B. Dunnett & S Killcross). £29,400 (Lilly) + £72,540 (BBSRC) to support Ellen Murphy studentship over 4 years from 1 October 2008
2008 Wellcome Trust Value in People award (EL Lane and SB Dunnett). £41,622 over 1 year from 1 October 2008
2008 MRC project grant (ND Allen, AE Rosser & SB Dunnett). G0701489. Development of a platform to generate clinical grade neural progenitors for transplantation in Huntington’s disease. £654,348 over 3 years. March 2008
2008 Parkinson’s Disease Society, Cheltenham and district branch. Donation for laboratory research equipment. £468, March 2008
2008 Parkinson’s Disease Society, Louth branch. Donation for laboratory research equipment contributed by Mr D Hackettt. £1730, March 2008.
2008 EU FP7 collaborative research programme (P Calabresi, SB Dunnett) HEALTH 2007-2.2.1-7. REPLACES: Restorative plasticity and corticostriatal excitatory synapses. €443,568 (£338,975) over 4 years.
2008 EU FP7 collaborative research programme (E Cataneo, SB Dunnett and others) HEALTH-2007-1.4-6. NeuroStemCell: Stem cell lines for cell-based therapies. €675,000 (£516,093) over 3 years.
2008 Royal Society research grant (SB Dunnett). Additional coils to enable detection of 19F fluoro-dopa by MRI. £15,000 equipment only.
2008 UKSCF/MRC Project grant (SB Dunnett & AE Rosser) G0601759. Validity, specificity and yields of clinical grade primary and expanded human fetal cells for neural transplantation. £811,379 over 3 years from 1 Feb 2008.
2008 HighQ Foundation (AL Jones, SB Dunnett & SP Brooks). A comparative study of behavioural and molecular changes in mouse models of Huntington's disease. £213,860 over 2 years from 1 Jan 2008
   
2007 Parkinson’s Disease Society, Chester & District branch. Donation for laboratory research equipment. £1,226, December 2007.
2007 Parkinson’s Disease Society, Falkirk branch. Donation for laboratory research equipment raised by the Perrott family in remembrance of Mrs. Wilma Perrott. £380, November 2007.
2007 Parkinson’s Disease Society, Eastbourne branch. Donation for laboratory research equipment. £1,172, November 2007.
2007 Hereditary Disease Foundation (L Jones & SB Dunnett). Phenotypic characterisation of HD mice. $75,000
2007 Parkinson’s Disease Society, Cheltenham & District branch. Donation for laboratory research equipment. £1,460
2007 Parkinson’s Disease Society, Newport branch. Donation for laboratory research equipment. £1,000
2007 Parkinson’s Disease Society, Cardiff branch. Donation for laboratory research equipment. £288
2007 Studienstiftung (U Weyrauch & SB Dunnett). Optimierung des transplantations­ver­fahrens von Embryonalen zellen des Ventralen Mesencephalons im Tiermodell der Parkinson Erkrankung. Studentship awarded to Ulrike Weyrauch. €24,480
2007 Parkinson’s Disease Society, South Powys branch. Donation for laboratory research equipment raised in memory of Mr John Stearne (1927-2007). £1,500
2007 Parkinson’s Disease Society (SB Dunnett, P Brundin, I Mendez & AE Rosser). Validation of a consensus protocol for preparing human embryonic nigral tissue in vitro and in vivo according to donor age, GMP preparation, and hibernation £161,923
   
2006 HighQ Foundation (AE Rosser & SB Dunnett). Euro HD Network. £156,657.
2006 ESRC Project grant (P Atkinson, J Kitzinger, P Glasner, SB Dunnett & R Chadwick). Stem cells CBAR – CESAgen work package. £294,957 over 2 years.
2006 EU FP6 specific targeted research project (Z Kokaia, A Smith, M Hoehn, L Minicello, SB Dunnett & L Wikström). Towards a stem cell therapy for stroke. € 388,073 (£272,794) over 3 years.
2006 Hereditary Disease Foundation (MD Döbrössy & SB Dunnett). Characterizing BAC transgenic mice lines expressing GFP under the control of D2 and M4 promoters corresponding to the striatal indirect and direct pathways, respectively.
2006 Hereditary Disease Foundation (AL Jones & SB Dunnett). A comparison of behavioural and gene expression changes in rodent models of Huntington’s disease. $150,000 (£87,328) over 1 year.
2006 HighQ Foundation (SB Dunnett, S Brooks & L Jones). A comparative study of behavioural and molecular changes in mouse models of Huntington’s disease. $228,122 (£126,734) over 1 year.
   
2005 MRC Strategic grant (ND Allen, S Chandran, A Rosser). Directed differentiation of human embryonic stem cells to forebrain neural progenitors. £271,914 over 3 years.
2005 BBSRC (AE Rosser and ND Allen). Modulation of fetal and adult neurogenesis by the Drd3 and Drd2 dopamine receptors. £227208 over 3 years.
2005 Parkinson’s Disease Society research grant (SB Dunnett & C Monville). Understand¬ing and eliminating the dyskinetic effects of nigral grafts. £148,192 over 3 years.
2005 MRC 5 year project grant (SB Dunnett & AE Rosser). Development and validation of functional cell therapies for Huntington’s and Parkinson’s diseases. £1,600,653 over 5 years.
2005 2005 Q-Chip Ltd CASE studentship (P Kille & SB Dunnett). Application of microfluidics to encapsulate cells as functionalised microparticles. Studentship awarded to Ms Vicki Workman. £19,824 over 3 years.
2005 The Lawrence family, Pontypool, Gwent. Stem cell research donation. £530.
2005 Parkinson’s Disease Society, Bridgend branch. Equipment donation. £500.
2005 Parkinson’s Disease Society, Arfon & Mon branch. Equipment donation. £2,500.
2005 Parkinson’s Disease Society, Northallerton branch. Equipment donation. £358.
2005 Parkinson’s Disease Society, Horsham branch. Equipment donation. £1,660.
2005 Parkinson’s Disease Society, Bridgend branch. Equipment donation. £2,750.
   
2004 HDSA (ND Allen, AL Jones, AE Rosser). Creation of a human model for Huntington’s disease by knock-in gene targeting of the HD locus in human embryonic stem cells. $50,000 over 12 months.
2004 Dunhill Trust. (AE Rosser and P Harper). Establishing a UK network for Huntington’s Disease. £109,500.
2004 MRC Research Studentship (SB Dunnett & SP Brooks) Operant analysis of behavioural deficits associated with the Huntington's disease mutation in transgenic mice. £33,900 over 3 years. Studentship awarded to Becky Trueman.
2004 BBSRC equipment grant (AR Clarke, T Dale, SB Dunnett, A Harwood, D Riccardi & M Taylor). Confocal microscopy studies of neuroscience, signalling and development. £199,999.
2004 Parkinson’s Disease Society, Cardiff branch. Equipment donation. £2500.
   
2003 Hereditary Disease Foundation. Cure HD Initiative award (SB Dunnett & AL Jones) Behavioural analysis of HD transgenic mice. £114,761 ($174,781) over 3 years.
2003 MRC Co-operative component grant. (SB Dunnett & AE Rosser). G0200489. SWIFT - the South Wales Initiative for Neural Transplantation in HD. £171,148 over 3 years.
2003 Parkinson's Disease Society. Research grant (SB Dunnett). Choice reaction time in rats: effects of alternative cell repair therapies on deficits induced by dopamine cell loss. £147,573 over 3 years.
2003 MRC Strategic grant (SB Dunnett, NJ Allen, N Amso, S Paynter and AE Rosser), G0300237. Optimal protocols for storage of embryonic and fetal neural stem cells. £280,822 over 3 years.
2003 MRC Strategic grant (SB Dunnett, A Amoroso, PJ Edwards & RA Fricker-Gates), G0300261. Novel protocols for magnetic imaging of stem cell transplants in the brain. £317,444 over 3 years.
   
2002 AFM/Téléphon (M Peschanski and SB Dunnett). Foetal neural transplants as a treatment for Huntington’s disease: from pilot studies to clinical application (EuroHD-PhaseII). €225,000 (£172,950) over 3 years.
   
1999 Medical Research Council clinical trial grant (SB Dunnett, AE Rosser, RA Barker & J Pickard). Safety and feasibility of neural transplantation in early to moderate Huntington's disease in the UK. £280,888 over 5 years.

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