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Pathophysiology and Repair

Embryonic stem (ES) cells growing in culture.

Embryonic stem (ES) cells growing in culture.

Pathophysiology and Repair focuses on the molecular mechanisms underpinning disease and the processes that drive repair and regeneration.  The Division has a broad strength that spans biochemistry, cell biology, molecular genetics and signal transduction. The groups within Pathophysiology and Repair focus on a variety of biological systems both in vivo and in vitro, and augment studies on human cell lines and tissues with studies in model organisms such as the mouse. Pathophysiology and Repair is a well-funded Division with excellent modern facilities for a broad range of techniques. It has close links with CITER, the Cardiff Institute of Tissue Engineering and Repair, and also with the Cardiff CR-UK Cancer Centre. The Division also has numerous global academic and industrial partners.

Professor Alan Clarke (Head of Division) 
Murine models of human cancer

Professor Daniela Riccardi (Deputy Head of Division)
Molecular mechanisms of nutrient sensing

Dr Emma Blain
Connective tissue mechanobiology

Dr Catherine Boulter
Regulation of stem/progenitor cells in development and disease

Professor Vladimir Buchman
Functional significance of synuclein proteins in the normal and degenerating nervous system.

Professor Bruce Caterson
Monoclonal antibody technologies to study onset of degenerative joint diseases

Dr Richard Clarkson
Apoptosis in normal mammary tissues and in models of breast cancer

Dr Joaquín de Navascués Melero
Stem cell decisions during intestinal homeostasis

Dr Wengsheng Deng (Independent Researcher Scheme)

Professor Vic Duance
Structure and function of the minor collagens of cartilage, cell signalling pathways associated with mechanical and cytokine mediated cartilage degeneration

Professor Michael Ehrmann
Protein quality control

Dr Peter Evans
Cell preservation technology

Dr George Foster
Development of autologous cell-based methods for repair of the degenerate nervous and immune systems

Dr Julia Gerasimenko
Molecular mechanisms of pathological processes in exocrine pancreas

Dr Oleg Gerasimenko
Investigation of cell death mechanisms

Dr Liming Gui
Maternal regulation of reprogramming and stem cells

Dr Catherine Hogan
Epithelial cell-cell communication and pancreatic cancer

Dr Paul Hole (Independent Researcher Scheme)
The roles of reactive oxygen species production in normal blood cells and in acute myeloid leukaemia

Dr Clare Hughes
Cartilage proteoglycan metabolism in osteoarthritis

Dr Rosalind John
How Epigenetic Marks direct Mammalian Development and drive Human Disease

Professor Paul Kemp
Induced pluripotent stem cells, neurodegenerative diseases, ion channels and oxygen sensing

Dr Branko Latinkic 
Cell fate determination in Xenopus 

Dr Kate Liddiard (Independent Researcher Scheme)
Novel technological approaches for investigating telomere dynamics in haematological malignancy

Dr Thet Lin (Independent Researcher Scheme)

Dr Emyr Lloyd-Evans 
Elucidating the function of lysosomes in health and disease 

Dr Stephen Man (Affliated Research Staff)
Regulation of cellular immunity in leukaemia

Dr Deborah Mason
Signalling mechanisms regulating bone and cartilage turnover, in osteoporosis, rheumatoid arthritis and osteoarthritis

Dr Lee Parry
Understanding the interaction between diet, microbiota, immunity and cancer

Dr Girish Patel (Affliated Research Staff)
Skin cancer stem cells

MRC Professor Ole Petersen CBE FRS
Calcium signalling: physiology & pathophysiology

Dr Dipak Ramji 
Inflammation, atherosclerosis and regulation of gene expression

Dr Karen Reed (Independent Researcher Scheme)
Interrogating the critical molecular events which contribute to initiation and progression of tumourigenesis

Dr Simon Reed (Affliated Research Staff)
Mechanisms of DNA damage and repair

Dr Neil Rodrigues
Haematopoietic stem/progenitor cell biology and its dysregulation in myelodysplasia and myeloid leukaemia

Dr Paul Shaw

Dr Florian Siebzehnrubl
Regulation of tumour progression and therapy resistance in brain cancer

Dr Matt Smalley
The role of normal mammary stem and progenitor cells in the generation of breast cancer phenotypic heterogeneity and cancer stem cells

Dr Martha Triantafilou (Affliated Research Staff)
Innate immune mechanisms in viral and bacterial infections


Affiliated Teaching Staff

Research Areas

Research within the Division is relevant to several areas of human disease, but is particularly strongly linked to cancer and tissue repair. The spectrum of research activities include:

  • Genetically engineered murine models of human cancer 
  • Epigenetics of normal development and disease
  • Mammary cancer and cell death 
  • Stem/progenitor cells in mammalian organogenesis
  • Pathophysiology of calcium signalling specifically related to pancreatitis
  • Inflammation, atherosclerosis and regulation of gene expression 
  • Molecular mechanisms of nutrient sensing
  • Monoclonal antibody technologies to study onset of degenerative joint diseases
  • Structure and function of the minor collagens of cartilage, cell signalling pathways associated with mechanical and cytokine mediated cartilage degeneration
  • Cartilage proteoglycan metabolism in osteoarthritis
  • Cellular control of extracellular matrix secretion and organisation in connective tissues 
  • Signalling mechanisms regulating bone and cartilage turnover, in osteoporosis, rheumatoid arthritis and osteoarthritis 
  • Connective tissue mechanobiology 
  • Functional significance of synuclein proteins in the normal and degenerating nervous system 
  • Investigation of cell death mechanisms 
  • Cell fate determination in Xenopus 
  • Elucidating the function of lysosomes in health and disease 
  • The role of normal mammary stem and progenitor cells in the generation of breast cancer phenotypic heterogeneity and cancer stem cells 
  • Cell preservation technology 
  • Development of autologous cell-based methods for repair of the degenerate nervous and immune systems 
  • Molecular mechanisms mediating channel regulation by reversible protein phosphorylation and mechanisms underlying volume regulation 
  • Morphogenetic mechanisms in the organisation of oriented connective tissues