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Dr Paul Shaw 

Position:Senior Lecturer

Telephone:+44(0) 2920 688510
Location:European Cancer Stem Cell Research Institute, Cardiff School of Biosciences Hadyn Ellis Building, Maindy Road, Cardiff CF24 4HQ

Research Overview

I am based in Prof Alan Clarke's laboratory in the European Cancer Stem Cell Research Institute. My research continues to explore and utilise genetically engineered mouse models of colorectal cancer and the therapeutic role of molecularly targeted novel anti-cancer agents against PI3K/mTOR and RAS/RAF/MEK/ERK signaling. This work complements the recognised strengths in personalised medicine (Stratified Medicine Programme, CRUK) and cancer genetics at Cardiff University. This research is now being extended to incorporate small animal PET imaging and novel tracer agents as predictive biomarkers of response to tailored anti-cancer agents (NISCHR funding, £217K over 2 years). I have recently secured funding from Cardiff CRUK Experimental Cancer Medicine Centre, to support a full-time research assistant in Prof. Trevor Dales’ laboratory to develop colorectal cancer organoids as an ‘ex vivo’ model system. A Cancer Research Wales PhD Studentship will further this work from October 2013. I am planning to extend this technique to include other solid tumours in particular lung cancer. Given the direction of my clinical work I am also seeking funding opportunities locally to develop a genetically engineered mouse model of lung cancer.

I am currently funded by NISCHR for research sessions, prior to this I was a Walport Clinical Lecturer and CRUK Bobby Moore Clinical Research Fellow. 

Research Division

Pathophysiology and Repair