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Prof Ole Petersen CBE FRS 


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Link to ScopusTM Database

Publications (from 2006)

Petersen, O.H. (2014) Calcium signalling and secretory epithelia. Cell Calcium in press, DOI: 10.1016/j.ceca.2014.01.003

Gerasimenko, J.V., Gerasimenko, O.V. and Petersen, O.H. (2014) The role of Ca2+ in the pathophysiology of pancreatitis J. Physiol. 592:2 269–280

Huang, W., Booth, D.M., Cane, M.C., Chvanov, M., Javed, M.A., Elliott, V.L., Armstrong, J.A., Dingsdale, H., Cash, N., Li, Y., Greenhalf, W., Mukherjee, R., Kaphalia, B.S., Jaffar, M., Petersen, O.H., Tepikin, A.V., Sutton, R. and Criddle, D.N. (2013) Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis. Gut  Doi: 10.1136/gutjnl-2012-304058

Hegyi, P. and Petersen, O.H. (2013) The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. Rev. Physiol. Biochem. Pharmacol. 165, 1-30.

Gerasimenko, J.V., Gryshchenko, O., Ferdek, P.E., Stapleton, E., Hebert, T.O.G., Bychkova, S., Peng, S., Begg, M., Gerasimenko, O.V. & Petersen, O.H. (2013) Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy Proc. Natl. Acad. Sci. USA (PNAS) 110, 13186-13191

Ferdek, P.E., Gerasimenko, J.V., Peng, S., Tepikin, A.V., Petersen, O.H. and Gerasimenko, O.V. (2012) A novel role for Bcl-2 in regulation of cellular calcium extrusion Curr. Biol. 22:1241-1246 

Petersen, O.H. (2012) Specific mitochondrial functions in separate sub-cellular domains of pancreatic acinar cells. Pflϋgers Arch. – Eur. J. Physiol. 464(1), 77-87

Petersen, O.H., Gerasimenko, O.V. and Gerasimenko, J.V. (2012) The war within - Unraveling the molecular causes of acute pancreatitis—a potentially deadly disease in which the pancreas essentially digests itself—is yielding clues to how it might be treated. The Scientist February 2012 26(2) 40-44

(Open Access: http://the-scientist.com/2012/02/01/the-war-within/)

Petersen, O.H., Gerasimenko, O.V. and Gerasimenko, J.V. (2011) Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin. F1000Reports Medicine 3: 15.

(Open Access: http://f1000.com/reports/m/3/15/pdf)

Gerasimenko, J.V., Lur, G., Ferdek, P., Sherwood, M.W., Ebisui, E., Tepikin, A.V., Mikoshiba, K., Petersen, O.H. and Gerasimenko, O.V. (2011) Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through inositol trisphosphate receptors. Proc. Natl. Acad. Sci. USA (PNAS) 108, 5873-5878.

(Open Access: http://www.pnas.org/content/108/14/5873.full.pdf+html)

Petersen, O.H., Gerasimenko, O.V., Tepikin, A.V. and Gerasimenko, J.V. (2011) Aberrant Ca2+ signalling through acidic Ca2+ stores in pancreatic acinar cells. Cell Calcium 50, 193-199.

Lur, G., Sherwood, M.W., Ebisui, E., Haynes, L., Feske, S., Sutton, R., Burgoyne, R.D., Mikoshiba, K., Petersen, O.H. and TepikinA.V. (2011) IP3 receptors and Orai channels in pancreatic acinar cells: co-localisation and its consequences. Biochem. J. 436, 231-239.

Booth, D.M., Murphy, J.A., Mukherjee, R., Awais, M., Neoptolemos, J.P., Gerasimenko, O.V., Tepikin, A.V., Petersen, O.H., Sutton, R. and Criddle, D.N. (2011) Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology 140, 2116-2125.

Gerasimenko JV, Lur G, Ferdek P, Sherwood MW, Ebisui E, Tepikin AV, Mikoshiba K, Petersen OH and Gerasimenko OV (2011) Calmodulin protects against alcohol-induced pancreatic trypsinogen activiation elicited via Ca2+ release through inositol trisphospate receptors PNAS 108(14) 5873-5878 doi:10.1073/pnas.1016534108

Chvanov, M., Petersen, O.H. & Tepikin, A.V. (2010) Pharmacologically directed cell disposal: labelling damaged cells for phagocytosis as a strategy against acute pancreatitis. Molecular Interventions 10, 80-85.

Voronina, S.G., Barrow, S.L., Simpson, A.W.M., Gerasimenko, O.V., Da Silva Xavier, G., Rutter, G.A., Petersen, O.H. & Tepikin, A.V. (2010) Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology 138, 1976-1987.

Criddle, D.N, Booth, D.M., Mukherjee, R., McLaughlin, E., Green, G.M., Sutton, R., Petersen, O.H. & Reeve, J.R. (2009) Cholecystokinin-58 and cholecystokinin-8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells. Am. J. Physiol. G. & L Physiology 297, G1085-G1092.

Gerasimenko, J.V., Lur, G., Sherwood, M.W., Ebisui, E., Tepikin, A.V., Mikoshiba, K., Gerasimenko, O.V. & Petersen, O.H. (2009) Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proc. Natl. Acad. Sci. USA (PNAS)106, 10758-10763.

Lur, G., Haynes, L.P., Prior, I.A., Gerasimenko, O.V., Feske, S., Petersen, O.H., Burgoyne, R.D. & Tepikin, A.V. (2009) Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Current Biology 19, 1648-1653.

Baumgartner, H.K., Gerasimenko, J.V., Thorne, C., Ferdek, P., Pozzan, T., Tepikin, A.V., Petersen, O.H., Sutton, R., Watson, A.J.M. & Gerasimenko, O.V. (2009) Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J. Biol. Chem. 284, 20796-20803.

Petersen, O.H., Tepikin, A.V., Gerasimenko, J.V., Gerasimenko, O.V., Sutton, R. & Criddle, D.N. (2009) Fatty acids, alcohol and fatty acid ethyl esters: toxic Ca2+ signal generation and acute pancreatitis. Cell Calcium 45, 634-642.

Walsh, C., Barrow, S., Voronina, S., Chvanov, M., Petersen, O.H. & Tepikin, A (2009) Modulation of calcium signaling by mitochondria. Biochim. Biophys. Acta 1787, 1374-1382.

Petersen, O.H. & Tepikin, A.V. (2008) Polarized calcium signaling in exocrine gland cells. Annu. Rev. Physiol.  70, 273-299.

Mukherjee, R., Criddle, D.N., Gukovaskaya, A., Pandol, S., Petersen, O.H. & Sutton, R. (2008) Mitochondrial injury in pancreatitis. Cell Calcium 44, 14-23.

Chvanov, M., Walsh, C.M., Haynes, L.P., Voronina, S.G., Lur, G., Gerasimenko, O.V., Barraclough, R., Rudland, P.S., Petersen, O.H., Burgoyne, R.D. & Tepikin, A.V. (2008) ATP depletion induces translocation to puncta and formation of STIM1 - ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflügers Arch.- Eur. J. Physiol. 457, 505-517.

Murphy, J.A., Criddle, D.N., Sherwood, M., Chvanov, M., Mukherjee, R.,  McLaughlin, E.,  Booth, D., Gerasimenko, J.V., Raraty, M.G.T., Ghaneh, P., Neoptolemos, J.P., Gerasimenko, O.V., Tepikin, A.V., Green, G.M., Reeve, J.R. Jr., Petersen, O.H. & Sutton, R. (2008) Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 135, 632-641. (See also Editorial: Gastroenterology 135, 357-360, 2008)

Barrow, S.L., Voronina, S.G., Da Silva Xavier, G, Chvanov, M.A., Longbottom, R.E., Gerasimenko, O.V., Petersen, O.H., Rutter, G.A., Tepikin, A.V. (2008) ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflügers Arch.- Eur. J. Physiol. 455, 1025-1029.

Park, M.K., Choi, Y.M., Kang, Y.K. & Petersen, O.H. (2008) The endoplasmic reticulum as an integrator of multiple dendritic events. Neuroscientist 14, 68-77.

Sherwood, M., Prior, I.A., Voronina, S.G., Barrow, S.L., Woodsmith, J.D., Gerasimenko, O.V., Petersen, O.H. & Tepikin, A.V. (2007) Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc. Natl. Acad. Sci. USA (PNAS) 104, 5674-5679.

Voronina, S.G., Sherwood, M., Gerasimenko, O.V.,  Petersen, O.H., Tepikin, A.V. (2007) Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran – bound indicator: endocytic and non-endocytic vacuoles. Am. J. Physiol. (G.I. & Liver) 293, G1333-G1338.

Petersen, O.H. & Verkhratsky, A. (2007) Endoplasmic reticulum calcium tunnels integrate signalling in polarized cells. Cell Calcium 42, 373-378.

Criddle D.N., Gerasimenko, J., Baumgartner, H.K., Jaffar, M., Voronina, S.G., Sutton, R., Petersen, O.H. & Gerasimenko, O.V. (2007) Calcium signalling and pancreatic cell death: apoptosis or necrosis? Cell Death Differ. 14, 1285-1294.

Nicotera, P, Petersen, O.H., Melino, G. and Verkhratsky, A. (2007) Janus a god with two faces: death and  survival utilise same mechanisms conserved by evolution. Cell Death Differ. 14, 1235-1236.

Baumgartner, H.K., Gerasimenko, J.V., Thorne, C., Ashurst, L.H., Barrow, S.L., Chvanov, M.A., Gillies, S., Criddle, D.N., Tepikin, A.V., Petersen, O.H., Sutton, R., Watson, A.J.M. & Gerasimenko, O.V. (2007) Caspase-8 – mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. Am. J. Physiol. (G-I & Liver) 293, G296-G307.

Criddle, D., Murphy, J., Fistetto, G., Barrow, S., Tepikin, A.V., Neoptolemos, J.P., Sutton, R. & Petersen, O.H. (2006) Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis. Gastroenterology 130, 781-793. (See also Editorial: Gastroenterology 130, 992-995).

Criddle, D.N., Gillies, S., Baumgartner-Wilson, H.K., Jaffar, M., Chinje, E.C., Passmore, S., Chvanov, M., Barrow, S., Gerasimenko, O.V., Tepikin, A.V., Sutton, R. & Petersen, O.H. (2006) Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. J. Biol. Chem. 281, 40485-40492.

Verkhratsky, A., Krishtal, O.A. and Petersen O.H. (2006) From Galvani to patch clamp: the development of electrophysiology. Pflügers Arch.-Eur. J. Physiol. 453, 233-248.

Petersen, O. H. and Sutton, R. (2006) Ca2+ signalling and pancreatitis: effects of alcohol, bile and coffee. Trends Pharmacol. Sci. (TIPS) 27, 113-120.

Petersen, O.H., Sutton, R. And Criddle, D.N. (2006) Failure of calcium microdomain generation and pathological consequences.  Cell Calcium 40, 593-600.

Chvanov, M., Gerasimenko O.V., Petersen, O.H. & Tepikin, A.V. (2006) Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO J. 25, 3024-3032.

Menteyne, A., Burdakov, A., Charpentier, G., Petersen, O.H. and Cancela, J.M. (2006) Generation of specific Ca2+ signals from Ca2+ stores and endocytosis by differential coupling to messengers. Current Biology 16, 1931-1937.

Gerasimenko, J.V., Flowerdew, S.E., Voronina, S.G., Sukhomlin, T.K., Tepikin, A.V., Petersen, O.H. & Gerasimenko, O.V. (2006) Bile acids induce Ca2+ release from both the ER and acidic intracellular calcium stores through activation of IP3Rs and RyRs. J. Biol. Chem. 281, 40154-40163.

Gerasimenko, J.V., Sherwood, M., Tepikin, A.V., Petersen, O.H. & Gerasimenko, O.V. (2006) NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. J. Cell Sci.  119, 226-238.