Prof Ole Petersen CBE FRS
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Publications (from 2006)
Petersen, O.H., Gerasimenko, O.V. and Gerasimenko, J.V. (2011) Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin. F1000Reports Medicine 3: 15.
(Open Access: http://f1000.com/reports/m/3/15/pdf)
Gerasimenko, J.V., Lur, G., Ferdek, P., Sherwood, M.W., Ebisui, E., Tepikin, A.V., Mikoshiba, K., Petersen, O.H. and Gerasimenko, O.V. (2011) Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through inositol trisphosphate receptors. Proc. Natl. Acad. Sci. USA (PNAS) 108, 5873-5878.
(Open Access: http://www.pnas.org/content/108/14/5873.full.pdf+html)
Petersen, O.H., Gerasimenko, O.V., Tepikin, A.V. and Gerasimenko, J.V. (2011) Aberrant Ca2+ signalling through acidic Ca2+ stores in pancreatic acinar cells. Cell Calcium 50, 193-199.
Lur, G., Sherwood, M.W., Ebisui, E., Haynes, L., Feske, S., Sutton, R., Burgoyne, R.D., Mikoshiba, K., Petersen, O.H. and TepikinA.V. (2011) IP3 receptors and Orai channels in pancreatic acinar cells: co-localisation and its consequences. Biochem. J. 436, 231-239.
Booth, D.M., Murphy, J.A., Mukherjee, R., Awais, M., Neoptolemos, J.P., Gerasimenko, O.V., Tepikin, A.V., Petersen, O.H., Sutton, R. and Criddle, D.N. (2011) Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology 140, 2116-2125.
Gerasimenko JV, Lur G, Ferdek P, Sherwood MW, Ebisui E, Tepikin AV, Mikoshiba K, Petersen OH and Gerasimenko OV (2011) Calmodulin protects against alcohol-induced pancreatic trypsinogen activiation elicited via Ca2+ release through inositol trisphospate receptors PNAS 108(14) 5873-5878 doi:10.1073/pnas.1016534108
Chvanov, M., Petersen, O.H. & Tepikin, A.V. (2010) Pharmacologically directed cell disposal: labelling damaged cells for phagocytosis as a strategy against acute pancreatitis. Molecular Interventions 10, 80-85.
Voronina, S.G., Barrow, S.L., Simpson, A.W.M., Gerasimenko, O.V., Da Silva Xavier, G., Rutter, G.A., Petersen, O.H. & Tepikin, A.V. (2010) Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology 138, 1976-1987.
Criddle, D.N, Booth, D.M., Mukherjee, R., McLaughlin, E., Green, G.M., Sutton, R., Petersen, O.H. & Reeve, J.R. (2009) Cholecystokinin-58 and cholecystokinin-8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells. Am. J. Physiol. G. & L Physiology 297, G1085-G1092.
Gerasimenko, J.V., Lur, G., Sherwood, M.W., Ebisui, E., Tepikin, A.V., Mikoshiba, K., Gerasimenko, O.V. & Petersen, O.H. (2009) Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proc. Natl. Acad. Sci. USA (PNAS)106, 10758-10763.
Lur, G., Haynes, L.P., Prior, I.A., Gerasimenko, O.V., Feske, S., Petersen, O.H., Burgoyne, R.D. & Tepikin, A.V. (2009) Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Current Biology 19, 1648-1653.
Baumgartner, H.K., Gerasimenko, J.V., Thorne, C., Ferdek, P., Pozzan, T., Tepikin, A.V., Petersen, O.H., Sutton, R., Watson, A.J.M. & Gerasimenko, O.V. (2009) Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J. Biol. Chem. 284, 20796-20803.
Petersen, O.H., Tepikin, A.V., Gerasimenko, J.V., Gerasimenko, O.V., Sutton, R. & Criddle, D.N. (2009) Fatty acids, alcohol and fatty acid ethyl esters: toxic Ca2+ signal generation and acute pancreatitis. Cell Calcium 45, 634-642.
Walsh, C., Barrow, S., Voronina, S., Chvanov, M., Petersen, O.H. & Tepikin, A (2009) Modulation of calcium signaling by mitochondria. Biochim. Biophys. Acta 1787, 1374-1382.
Petersen, O.H. & Tepikin, A.V. (2008) Polarized calcium signaling in exocrine gland cells. Annu. Rev. Physiol. 70, 273-299.
Mukherjee, R., Criddle, D.N., Gukovaskaya, A., Pandol, S., Petersen, O.H. & Sutton, R. (2008) Mitochondrial injury in pancreatitis. Cell Calcium 44, 14-23.
Chvanov, M., Walsh, C.M., Haynes, L.P., Voronina, S.G., Lur, G., Gerasimenko, O.V., Barraclough, R., Rudland, P.S., Petersen, O.H., Burgoyne, R.D. & Tepikin, A.V. (2008) ATP depletion induces translocation to puncta and formation of STIM1 - ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflügers Arch.- Eur. J. Physiol. 457, 505-517.
Murphy, J.A., Criddle, D.N., Sherwood, M., Chvanov, M., Mukherjee, R., McLaughlin, E., Booth, D., Gerasimenko, J.V., Raraty, M.G.T., Ghaneh, P., Neoptolemos, J.P., Gerasimenko, O.V., Tepikin, A.V., Green, G.M., Reeve, J.R. Jr., Petersen, O.H. & Sutton, R. (2008) Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 135, 632-641. (See also Editorial: Gastroenterology 135, 357-360, 2008)
Barrow, S.L., Voronina, S.G., Da Silva Xavier, G, Chvanov, M.A., Longbottom, R.E., Gerasimenko, O.V., Petersen, O.H., Rutter, G.A., Tepikin, A.V. (2008) ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflügers Arch.- Eur. J. Physiol. 455, 1025-1029.
Park, M.K., Choi, Y.M., Kang, Y.K. & Petersen, O.H. (2008) The endoplasmic reticulum as an integrator of multiple dendritic events. Neuroscientist 14, 68-77.
Sherwood, M., Prior, I.A., Voronina, S.G., Barrow, S.L., Woodsmith, J.D., Gerasimenko, O.V., Petersen, O.H. & Tepikin, A.V. (2007) Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc. Natl. Acad. Sci. USA (PNAS) 104, 5674-5679.
Voronina, S.G., Sherwood, M., Gerasimenko, O.V., Petersen, O.H., Tepikin, A.V. (2007) Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran – bound indicator: endocytic and non-endocytic vacuoles. Am. J. Physiol. (G.I. & Liver) 293, G1333-G1338.
Petersen, O.H. & Verkhratsky, A. (2007) Endoplasmic reticulum calcium tunnels integrate signalling in polarized cells. Cell Calcium 42, 373-378.
Criddle D.N., Gerasimenko, J., Baumgartner, H.K., Jaffar, M., Voronina, S.G., Sutton, R., Petersen, O.H. & Gerasimenko, O.V. (2007) Calcium signalling and pancreatic cell death: apoptosis or necrosis? Cell Death Differ. 14, 1285-1294.
Nicotera, P, Petersen, O.H., Melino, G. and Verkhratsky, A. (2007) Janus a god with two faces: death and survival utilise same mechanisms conserved by evolution. Cell Death Differ. 14, 1235-1236.
Baumgartner, H.K., Gerasimenko, J.V., Thorne, C., Ashurst, L.H., Barrow, S.L., Chvanov, M.A., Gillies, S., Criddle, D.N., Tepikin, A.V., Petersen, O.H., Sutton, R., Watson, A.J.M. & Gerasimenko, O.V. (2007) Caspase-8 – mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. Am. J. Physiol. (G-I & Liver) 293, G296-G307.
Criddle, D., Murphy, J., Fistetto, G., Barrow, S., Tepikin, A.V., Neoptolemos, J.P., Sutton, R. & Petersen, O.H. (2006) Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis. Gastroenterology 130, 781-793. (See also Editorial: Gastroenterology 130, 992-995).
Criddle, D.N., Gillies, S., Baumgartner-Wilson, H.K., Jaffar, M., Chinje, E.C., Passmore, S., Chvanov, M., Barrow, S., Gerasimenko, O.V., Tepikin, A.V., Sutton, R. & Petersen, O.H. (2006) Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. J. Biol. Chem. 281, 40485-40492.
Verkhratsky, A., Krishtal, O.A. and Petersen O.H. (2006) From Galvani to patch clamp: the development of electrophysiology. Pflügers Arch.-Eur. J. Physiol. 453, 233-248.
Petersen, O. H. and Sutton, R. (2006) Ca2+ signalling and pancreatitis: effects of alcohol, bile and coffee. Trends Pharmacol. Sci. (TIPS) 27, 113-120.
Petersen, O.H., Sutton, R. And Criddle, D.N. (2006) Failure of calcium microdomain generation and pathological consequences. Cell Calcium 40, 593-600.
Chvanov, M., Gerasimenko O.V., Petersen, O.H. & Tepikin, A.V. (2006) Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO J. 25, 3024-3032.
Menteyne, A., Burdakov, A., Charpentier, G., Petersen, O.H. and Cancela, J.M. (2006) Generation of specific Ca2+ signals from Ca2+ stores and endocytosis by differential coupling to messengers. Current Biology 16, 1931-1937.
Gerasimenko, J.V., Flowerdew, S.E., Voronina, S.G., Sukhomlin, T.K., Tepikin, A.V., Petersen, O.H. & Gerasimenko, O.V. (2006) Bile acids induce Ca2+ release from both the ER and acidic intracellular calcium stores through activation of IP3Rs and RyRs. J. Biol. Chem. 281, 40154-40163.
Gerasimenko, J.V., Sherwood, M., Tepikin, A.V., Petersen, O.H. & Gerasimenko, O.V. (2006) NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. J. Cell Sci. 119, 226-238.