Prof Eshwar Mahenthiralingam - PhD
Telephone:+44 (0)29 208 75875
Fax:+44 (0)29 208 74305
Location:Cardiff School of Biosciences, Main Building, Museum Avenue, Cardiff, CF10 3AT
My group has studied the pathogenesis and ecology of bacterial opportunistic pathogens, ranging from Pseudomonas aeruginosa to mycobacteria, with a major focus on Burkholderia cepacia complex bacteria. Pseudomonas and Burkholderia bacteria cause devastating infections in people with cystic fibrosis and we have used molecular biology and genomic approaches to track their ability to spread between patients, resist killing by antibiotics and cause lung disease. Since both these bacteria are also important in the natural environment, we have also studied several aspects of their ecology. By understanding the complete biology of opportunistic bacterial pathogens in this way we hope to develop strategies to both treat human infection and also harness their considerable biotechnological potential. For example, our recent discovery that Burkholderia bacteria can produce novel polyketide antibiotics that target multidrug resistant bacterial infections is very exciting.