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Prof Eshwar Mahenthiralingam  -  PhD


Photo of Dr. E. (Esh) Mahenthiralingam
Position:Professor

Telephone:+44 (0)29 208 75875
Fax:+44 (0)29 208 74305
Extension:75875
Location:Cardiff School of Biosciences, Main Building, Museum Avenue, Cardiff, CF10 3AT

Research Overview

Chemistry and Biology - Journal

My group has studied the pathogenesis and ecology of bacterial opportunistic pathogens, ranging from Pseudomonas aeruginosa to mycobacteria, with a major focus on Burkholderia cepacia complex bacteria. Pseudomonas and Burkholderia bacteria cause devastating infections in people with cystic fibrosis and we have used molecular biology and genomic approaches to track their ability to spread between patients, resist killing by antibiotics and cause lung disease. Since both these bacteria are also important in the natural environment, we have also studied several aspects of their ecology. By understanding the complete biology of opportunistic bacterial pathogens in this way we hope to develop strategies to both treat human infection and also harness their considerable biotechnological potential. For example, our recent discovery that Burkholderia bacteria can produce novel polyketide antibiotics that target multidrug resistant bacterial infections is very exciting.

We are pleased to announced the forthcoming publication of a second book on Burkholderia bacteria: "Burkholderia: from genomes to function" which can be previewed at Horizon Press (http://www.horizonpress.com/burk2).

The book was edited by Tom Coenye and myself and serves as an excellent update to the highly successful first book: "Burkholderia: molecular microbiology and genomics" (http://www.horizonpress.com/backlist/horizonbioscience/burk.html).

Research Division

Organisms and Environment