Dr Nicholas A. Kent - DPhil
Telephone:+44 (0)29 208 79036
Fax:+44 (0)29 208 74116
Location:School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
DNA in cells does not function as a naked double helix, but exists in complex with various structural proteins to form chromatin. The modulation of chromatin structure is a key process in the catalysis and regulation of gene transcription, DNA replication and DNA repair. With a view to understanding processes defective in cancer and cell ageing, the Kent lab uses novel next-generation chromatin sequencing techniques to analyse chromatin-remodeller function in a variety of eukaryotic cell models at a genome-wide level, and also works on the mechanisms of chromatin-remodelling regulating DNA break formation and repair. We are currently funded by the BBSRC and The Royal Society.
The Kent Lab webpages (including Supplementary Data for recent publications) can be found here