Dr Clare Hughes - PhD
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Selected Publications
Rees SG, Waggett AD, Kerr BC, Probert, J. Gealy, E. C Dent, C. M., Caterson, B, Hughes, C. E. (2009) Immunolocalisation and expression of keratocan in tendon OSTEOARTHRITIS AND CARTILAGE 17(2) P.276-279
Hayes AJ, Tudor D, Nowell MA, Bruce Caterson and Clare E Hughes (2008) Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 56(2) P. 125-138
Melrose J, Fuller ES, Roughley PJ, Smith, Margaret M. Kerr, Briedgeen, Hughes, Clare E., Caterson, Bruce, Little, Christopher B.(2008) Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues ARTHRITIS RESEARCH & THERAPY 10(4) Article Number: R79
Powell, AJ; Little, CB; Hughes, CE (2007) Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aaarecan in a porcine chondrocyte culture system ARTHRITIS AND RHEUMATISM 56(9) P. 3010-3019 DOI: 10.1002/art.22818
Bondeson, J; Lauder, S; Wainwright, S; Amos, N; Evans, A; Hughes, C; Feldmann, M; Caterson, B; (2007) Adenoviral gene transfer of the endogenous inhibitor I kappa B alpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappa B-dependent JOURNAL OF RHEUMATOLOGY 34 (3) P. 523-533
Jones, ARC; Gleghorn, JP; Hughes, CE; Fitz, LJ; Zollner, R; Wainwright, SD; Caterson, B; Morris, EA; Bonassar, LJ; Flannery, CR; (2007) Binding and localization of recombinant lubricin to articular cartilage surfaces JOURNAL OF ORTHOPAEDIC RESEARCH 25 (3) P. 283-292 DOI: 10.1002/jor.20325
Gendron, C; Kashiwagi, M; Lim, NH; Enghild, JJ; Thogersen, IB; Hughes, C; Caterson, B; Nagase, H (2007) Proteolytic activities of human ADAMTS-5 - Comparative studies with ADAMTS-4 JOURNAL OF BIOLOGICAL CHEMISTRY 282 (25) P.18294-18306 DOI: 10.1074/jbc.M701523200
Wainwright, SD; Bondeson, J; Hughes, CE (2006) An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients MATRIX BIOLOGY 25 (5) P. 317-320 DOI: 10.1016/j.matbio.2006.03.006
Bondeson, J; Wainwright, SD; Lauder, S; Amos, N; Hughes, CE (2006) The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis ARTHRITIS RESEARCH & THERAPY 8(6) DOI: 10.1186/ar2099
Grau, S; Richards, PJ; Kerr, B; Hughes, C; Caterson, B; Williams, AS; Junker U; Jones, SA; Clausen, T; Ehrmann, M (2006) The role of human HtrA1 in arthritic disease JOURNAL OF BIOLOGICAL CHEMISTRY 281 (10) P. 6124-6129 DOI: 10.1074/jbc.M500361200