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Dr Clare Hughes  -  PhD

Position:Senior Lecturer

Telephone:+44 (0)29 208 76417
Location:Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX

Research Overview

Research interests include:

  1. The mechanisms by which ADAMTS-4 & TS-5 (‘the aggrecanases’ ) are involved in cartilage destruction during the pathogenesis of osteoarthritis.  Part of this work has led to the novel discovery of an alternative splice-variant of ADAMTS-4 synthesised in synovial tissue.
  2. The mechanisms by which glycosaminoglycan sulphation motifs influence the differentiation of mesenchymal stem cells to connective tissue lineages with a particular focus on chondrogenesis.
  3. The pathogenesis of Kashin Beck Disease an endemic osteoarthropathy in China.

Research Division

Pathophysiology and Repair