Ms Elizabeth Fraser
Telephone:+44(0)29 208 79073
Location:Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
BIOCHEMICAL ANALYSIS OF THE MECHANISM OF ACTION OF NOVEL, SMALL-MOLECULE, WNT-SIGNALLING INHIBITORS
In collaboration with Merck-Serono and the Institute of Cancer Research, we have identified novel compounds that inhibit Wnt signalling, for potential use as cancer therapeutics. The initial screen was a phenotypic assay looking for inhibiton of a Wnt-inducible cell-line developed in the lab. My recent work on this project has involved 2D gel-analysis to identify the target protein, monoclonal antibody screening and biomarker assays. I am also involved in a project looking at novel GSK3 binding proteins.