Dr George Foster
Telephone:+44(0)29 208 74101
Location:Cardiff School of Biosciences, Main Building, Museum Avenue, Cardiff, CF10 3AX
My research is fundamentally oriented towards the concept that most chronic diseases are the result of a loss of cells. Only, therefore, chronic treatments will satisfactorily restore all the functional characteristics of the original cells, be they dopamine neurones in Parkinson’s disease, -islets in diabetes or osteoprogenitors in bone fracture. This sounds complex, and is, but one recent discovery is that such degenerating cells can be replaced in vivo by the action of the extracellular matrix they produce in culture. This phenomenon should do away with the need for immunosuppression of the grafted cells. In another way of ensuring graft survival/safety, we are transfecting a negative selection device that will completely destroy all graft cells, or instead, eradicate all the neighbouring cells.