Prof Victor Duance - PhD
Recent Publications
Vaughan-Thomas, A., Young, RD, Phillips, AC and Duance, VC (2001) Interaction of type XI collagen with heparin: role in chondrocyte-matrix interaction J.Biol.Chem. 276 (7) 5303-5309.
Eriksen TA, Wright DM, Purslow PP & Duance VC (2001) The role of calcium in the mechanical properties of fibrillin. Proteins 45, 90-95.
Blain EJ, Gilbert SJ, Wardale RJ, Capper SJ Mason DJ & Duance VC (2001) Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Arch. Biochem. Biophys. 396, 49-55.
Young RD , Vaughan -Thomas A, Wardale RJ, Duance VC (2002) Type II collagen deposition in cruciate ligament precedes osteoarthritis in the knee. Osteoarthritis Cartilage. 10(5):420-8.
Blain EJ, Mason DJ & Duance VC (2002) The effect of thymosin b4 on articular cartilage chondrocyte MMP expression. Biochem. Soc Trans. 30 (6) 879-882.
Gilbert SJ, Duance VC & Mason DJ (2002) TNF-a up-regulates PACT and increases phosphorylation of PKR and eIF2-a in articular chondrocytes. Biochem. Soc Trans. 30 (6) 886-889.
Blain EJ Mason D & Duance V (2003) Effect of mechanical stimulation on MMP expression in chondrocytes. Biorheology 40, 111-117.
Duance VC (2003) Get connected with connective tissues. The Biochemist 25(5) 7-10.
Gilbert SJ, Duance VC , Mason DJ (2004) Does protein kinase R mediate TNF- a - and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism? Arthritis Res Ther 6(1), R46-R55.
Duance VC & Roberts S. (2004) “The Intervertebral Disc” in “Soft Tissue Rheumatology” Eds B Hazelman, G Riley and C Speed. pp 54-79.
Blain EJ, Gilbert SJ, Duance VC (2006). Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis. Matrix Biology 25(7) 398-408.
Gilbert SJ, Blain EJ, Jones P, Duance VC, Mason DJ (2006) Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis Res Ther 8(4), R89-R100.
Gilbert SJ, Duance VC, Mason DJ (2006) PKR: a novel role in arthritic disease. Current Rheumatology Reviews 2(1), 9-21. (Invited review).
Li S, Duance VC & Blain EJ. F-actin cytoskeletal organization in intervertebral disc health and disease. Biochem. Trans. 35(4) 683-685 2007
Flood S, Parri R, Williams A, Duance V, Mason D (2007) Functional ionotropic glutamate receptors modulate IL-6 and MMP-2 expression in fibroblast-like synoviocytes. Arthritis & Rheum 56:2523-34
Li S, Duance VC, Blain EJ (2008) Zonal variations in cytoskeletal element organization, mRNA and protein expression in the intervertebral disc. J Anat 213(6): 725-32
Davies LC, Blain EJ*, Gilbert SJ, Caterson B, Duance VC. (2008) The potential of IGF-1 and TGFbeta1 for promoting "adult" articular cartilage repair: an in vitro study. Tissue Eng Part A 14(7): 1251-61
Gilbert S, Blain E, Duance V, Mason D. (2008) Sphingomyelinase decreases type II collagen expression in articular chondrocytes via the ERK signaling pathway. Arthritis & Rheum. 58:209-220
Davies LC, Blain EJ, Caterson B Duance VC (2008) Chondroitin Sulphate Impedes the Migration of a Sub-population of Articular Cartilage Chondrocytes.Osteoarthritis Cartilage 16: 855-864.
Khan IM, Gilbert SJ, Singhrao SK, Duance VC, Archer CW. (2008) Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. A review. Eur Cell Mater. 16:26-39.
Vaughan-Thomas A, Dudhia J, Bayliss M, Kadler K, Duance V (2008) Modification of the composition of articular cartilage collagen fibrils with increasing age. Connect Tiss Res. 49(5):374-82.
Gilbert SJ, Singhrao SK, Khan I, Gonzalez L, Thomson B, Burdon D, Duance VC, Archer CW. Enhanced tissue integration during cartilage repair in vitro can be achieved by inhibiting chondrocyte death at the wound edge. Tissue Eng Part A (Epub ahead of print).
Blain EJ, Duance VC Chapter 1.4 Tissue Injury and repair – meniscus. Oxford Textbook of Sports Injuries. Editors – Hutson M, Speed C. (in press).
Sally Roberts, Jai Trivedi & Victor C Duance Chapter 1.5 The Intervertebral Disc And The Spine Oxford Textbook of Sports Injuries. Editors – Hutson M, Speed C. (in press).
Selected Previous Publications
Duance, VC, Restall, DJ, Beard, HK, Bourne, FJ & Bailey, AJ (1977) The location of three collagen types in skeletal muscle. FEBS Lett., 79, 248-252.
Bailey, AJ, Shellswell, GB & Duance, VC (1979) Identification of collagen isotypes in differentiating myoblasts and developing chick muscle. Nature, 278, 67-69.
Duance, VC, Black, CM, Bailey, AJ, Hughes, GRV & Dubowitz, V (1980) Polymyositis. An immunofluorescence study on the distribution of collagen types. Muscle and Nerve, 3, 482-490.
Duance, VC, Stephens, HR, Dunn, M, Bailey, AJ & Dubowitz, V (1980) A role for collagen in the pathogenesis of muscular dystrophy? Nature, 284, 470-472.
Shimokomaki, M, Duance, VC & Bailey, AJ (1980) Identification of a new disulphide- bonded collagen from cartilage. FEBS Lett., 121, 51-54.
Black, C.M, Duance, VC, Light, ND and Bailey, AJ (1982) Immunological and biochemical investigation into collagen changes in scleroderma. Annals of Rheumatic Diseases 41, 194.
Black, CM, Duance, VC, Sims, TJ, Light, ND (1983) An investigation of the biochemical and histological changes in the collagen of the kidney and skeletal muscle in systemic sclerosis. Collagen & Rel. Res. 3, 231-244.
Gadher, SJ, Eyre, DR, Duance, VC, Wotton, SF, Heck, L, Schmid, TM & Woolley, D (1988). Susceptibility of cartilage collagens Types II, IX, X and XI to human synovial collagenase and neutrophil elastase. Eur. J. Biochem. 175, 1-7.
Wotton, SF, Duance, VC & Fryer, PR (1988). Type IX collagen. A possible function in articular cartilage. FEBS. Letts. 234, 79-82.
Wotton, SF, Jeacocke, RE, Maciewicz, RA, Wardale, RJ, Duance, VC (1991). The application of scanning confocal microscopy in cartilage research. Histochem. J. 23, 328-335.
Wardale, RJ & Duance VC (1993). Quantitation and immunolocalisation of porcine articular and growth plate cartilage collagens. J. Cell Sci. 105, 975-984.
Wardale, RJ & Duance, VC (1994). Characterisation of articular and growth plate cartilage in porcine osteochondrosis. J. Cell. Sci. 107, 47-59.
Wardale, RJ & Duance, VC (1996). Collagen Expression in Chicken Tibial Dyschondroplasia. J. Cell Sci. 109, 1119-1131.
Wotton SF, Dieppe PA & Duance VC (1999) Identification of immunoreactive collagenous components in synovial fluids from arthritis patients. Rheumatology 38, 338-345.
Young RD, Lawrence PA, Duance VC, Aigner T & Monaghan P (2000) Immunolocalisation of collagen types II and III in single fibrils of human articular cartilage. J Histo Cytochem.48, 423-432.
Vaughan-Thomas, A, Gilbert, SJ, & Duance, VC (2000) Elevated levels of proteolytic enzymes in the aging human vitreous. Invest. Ophthalmol & Vis. Sci. 41, 3299-3304.