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Prof Alun Davies FRS 


GFP-transfected embryonic sensory neuron in culture

GFP-transfected embryonic sensory neuron in culture

We use a variety of approaches to investigate how secreted signalling molecules affect the generation and survival of neurons and influence the establishment and modification of their connections in the developing vertebrate nervous system. We have established well-characterised cell culture systems to ascertain the roles of these factors at defined stages in neuroblast and neuronal development and we transgenic technology to investigate the consequences of null mutations the genes encoding these factors, their receptors and other regulatory molecules. We also have a particular current interest in the role of the NF-kB family of transcription factors in regulating the growth of neural processes.

Research Team Members

Post-docs

Dr Laura Howard

Dr Tom McWilliams

Dr Catarina Osório

Dr Jovita Ponce Torrent

bIII tubulin stained cortical neurons in culture

bIII tubulin stained cortical neurons in culture

PhD students

Mr Matthew White

Ms Clara Erice Jurecky

Mr Christopher Laurie (co-supervisor with Dr. Sean Wyatt)

Research Grants

Wellcome Trust Programme Grant, 2008-2014
 £1,366,318 
"The TNF superfamily in neuronal development"