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Prof Alun Davies FRS 


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Selected Publications

McWilliams T, Howard L and Davies, A.M. (2015) Regulation of autocrine signalling in subsets of sympathetic neurons has regional effects on tissue innervation Cell Reports 10(9), pp. 1443-1449

Kisiswa L, Osório C, Erice C, Vizard T, Wyatt S and Davies A.M. (2013) TNF reverse signalling promotes sympathetic axon growth and target innervation. Nature Neuroscience 16(7), pp. 865-873 

Osório C, Chacon P, Kisiswa L, White M, Wyatt S, Rodriguez-Tebar A and Davies A (2013) Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development Development 140(23), pp. 4751-4762 

Howard L, Wyatt S, Nagappan G and Davies A.M. (2013) ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75(NTR)-dependent mechanism Development 140(10) pp. 2108-2117

O’Keeffe G, Gutierrez H, Pandolfi P.P., Riccardi C, Davies A.M. (2008) NGF-promoted axon growth and target innervation requires GITRL-GITR signallingNature Neuroscience 11(2), pp. 135-142 

Vizard T.N., O’Keeffe G, Gutierrez H, Kos C, Riccardi D, Davies A.M. Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor Nature Neuroscience 11(3), pp. 285-291 

Gutierrez H, Hale V.A., Dolcet X and Davies A.M. (2005) NF-kappaβ signalling regulates the growth of neural processes in the developing PNS and CNS Development, pp. 1713-1726 

Orike N, Middleton G, Buchman V.L., Cowen T and Davies A.M. (2001) Role of PI 3-kinase, Akt and Bcl-2 related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons Journal of Cell Biology, pp. 995-1005 

Barker, V., Middleton, G., Davey, F. and Davies, A. M. (2001) Role for TNFa in accelerating neuronal apoptosis following NGF deprivation  Nature Neuroscience 4, pp. 1194-1198

Buchman, V. L., Adu, J., Pinõn, L. G. P., Ninkina, N. N. and Davies, A. M. (1998) Persyn, a novel synuclein, influences neurofilament network integrity.  Nature Neuroscience 1, pp. 101-103

Maina, F., Hilton, M. C., Andres, R., Wyatt, S., Klein, R. and Davies, A. M. (1998) Multiple roles for hepatocyte growth factor in sympathetic neuron development.  Neuron 20, pp. 835-846

Buj-Bello, A., Adu, J., Piñón, L. G. P., Horton, A., Thompson, J., Rosenthal, A., Chinchetru, M., Buchman, V. L. and Davies, A. M. (1997) Neurturin responsiveness requires a GPI-linked receptor plus the Ret receptor tyrosine kinase.  Nature 387, pp. 721-724

Wyatt, S., Piñón, L. G. P., Ernfors, P. and Davies, A. M. (1997) Sympathetic neuron survival and TrkA expression in NT3-deficient mouse embryos.  EMBO Journal  16, pp. 3115-3123

Ninkina, N., Adu, J., Fischer, A., Piñón, L. G., Buchman, V. L. and Davies, A. M.  (1996) Expression and function of TrkB variants in developing sensory neurons.  EMBO Journal 15, pp. 6385-6393

Buj-Bello, A., Buchman, V. L., Horton, A., Rosenthal, A. and Davies, A. M. (1995) GDNF is an age-specific survival factor for sensory and autonomic neurons.  Neuron 15, pp.  821-828

Davies, A. M., Minichiello, L. and Klein, R. (1995) Developmental changes in NT3 signalling via TrkA and TrkB in embryonic neurons.  EMBO Journal 14, pp.  4482-4489

Davies, A. M., Lee, K. F. and Jaenisch, R. (1993) p75-deficient trigeminal neurons have an altered response to NGF but not to other neurotrophins. Neuron 11, pp. 565-574

Allsopp, T., Robinson, M., Wyatt, S. and Davies, A. M. (1993) Ectopic TrkA expression mediates an NGF survival response in NGF-independent sensory neurons but not in parasympathetic neurons.  Journal of Cell Biology  123, pp. 1555-1566

Allsopp, T., Wyatt, S., Patterson, H. and Davies, A. M. (1993) The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell  73, pp. 295-307

Buchman, V. I. and Davies, A. M. (1993) Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons. Development 118, pp. 989-1001

Wright, E., Vogel, K. S. and Davies, A. M. (1992) Neurotrophic factors promote the maturation of developing sensory neurons before they become dependent on these factors for survival.  Neuron 9, pp. 139-150

Larmet, Y., Dolphin, A. C. and Davies, A. M. (1992) Intracellular calcium regulates the survival of early sensory neurons before they become dependent on neurotrophic factors. Neuron 9, pp.  563-574

Vogel, K. S. and Davies, A. M. (1991) Duration of neurotrophic factor independence in early sensory neurons is matched to the time-course of target field innervation. Neuron 7, pp. 819-830

Wyatt, S., Shooter, E.M. and Davies, A. M. (1990) Expression of the NGF receptor gene in sensory neurons and their cutaneous targets prior to and during innervation. Neuron  4, pp. 421-427

Davies, A. M. (1989) Intrinsic differences in the growth rate of early nerve fibres related to target distance. Nature  337, pp. 553-555

Davies, A. M., Bandtlow, C., Heumann, R., Korsching, S. Rohrer, H. and Thoenen, H. (1987) Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor. Nature  326, pp. 353-358

Lumsden, A.G.S. and Davies, A. M. (1986) Chemotropic effect of specific target epithelium in the developing mammalian nervous system.  Nature  323, pp.  538-539

Davies, A. M., Thoenen, H. and Barde, Y.-A. (1986) Different factors from the central nervous system and periphery regulate the survival of sensory neurones. Nature  319, pp. 497-499 

Lumsden, A. G. S. and Davies, A. M.  (1983) Earliest sensory nerve fibres are guided to peripheral targets by attractants other than nerve growth factor. Nature 306, pp. 786-788