Prof Trevor Dale - PhD
Telephone:+44 (0)29 208 74652
Fax:+44 (0)29 208 74116
Location:Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
The primary focus of research in the group is the regulation of the Wnt signal transduction pathway. Wnts together with other peptide ligands including the FGF, EGF, TGF-β and hedgehog families orchestrate cell-cell interactions throughout development. Much of the specificity of each ligand’s function is controlled by intracellular pathways that are activated at the cell surface. Components of the Wnt/β-catenin pathway are frequently mutated in human cancer. This laboratory studies normal and oncogenic Wnt signalling using approaches ranging from biochemistry/structural biology, through cell and organoid based assays to murine models.
Specific projects include:
- The biochemistry of Wnt pathway components such as the kinase GSK-3
- The identification of novel Wnt regulators through high throughput cDNA, siRNA and drug screening.
- The analysis of normal and oncogenic Wnt signalling using murine models and 3D organoid culture systems
Research in the group has led to the recent establishment of a spin out company to commercialise a novel technology for high throughput quantitative protein-interaction assays. (see www.nanotether.co.uk).