Prof Alan Clarke - PhD
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Selected Publications
Shorning B, Zabkiewicz J, McCarthy A, Pearson H, Winton DJ, Sansom OJ, Ashworth A and Clarke AR (2009) Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine. PloS One 4(1):e4264. Epub 2009 Jan 23.
Pearson HB, Phesse TJ and Clarke AR (2009) K-ras and Wnt signalling synergise to accelerate prostate tumourigenesis in the mouse. Cancer Research 69(1):94-101.
Barker N, Ridgway RA, van Es JH., van de Wetering M, Begthel H, van den Born M, Danenberg, Clarke AR, Sansom OJ and Clevers H (2009) Crypt Stem Cells as the Cells-of-Origin of Intestinal Cancer. Nature 457 (7229):608-11. Epub 2008 Dec 17.
Reed K, Athineos D, Meniel V, Wilkins J, Ridgway R, Burke Z, Muncan V, Clarke AR and Sansom OJ (2008) B-catenin deficiency (but not Myc deletion) suppresses the immediate phenotypes of Apc loss in the liver. PNAS 105(48):18919-23. Epub 2008 Nov 24.
Marsh V, Winton DJ, Williams GT, Dubois N, Trumpp A, Sansom OJ and Clarke AR. (2008) Epithelial Pten is dispensable for intestinal homeostasis, but suppresses adenoma development and progression following Apc mutation. Nature Genetics 40(12):1436-44. Epub 2008 Nov 16.
Pearson HB, McCarthy A, Collins CM, Ashworth A, Clarke AR. (2008) Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res.68(7):2223-32.
Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H and Clarke AR.(2007) C-Myc deletion rescues Apc deficiency in the small intestine. Nature Apr 5; 446(7136):676-9.
Sansom OJ, Meniel V, Wilkins JA, Cole A, Oien K, Jamieson T, Ashton G, Barbacid M, Clarke AR. (2006) Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc. Natl. Acad. Sci. USA. 2006 Sep19; 103(38):14122-7. Epub 2006 Sep 7.
Sansom OJ, Reed K, Hayes AJ, Ireland H, Brinkmann H, Newton IP, Batlle E, Simon-Assmann P, Clevers H, Nathke IS, Clarke AR and Winton DJ. (2004) Loss of Apc immediately perturbs differentiation and migration in the small intestine. Genes and Development 18: 1385-1390.
Sansom OJ, Berger J, Bishop SM, Hendrich B, Bird A and Clarke AR (2003) Deficiency of the DNA methylation-dependent transcriptional repressor Mbd2 suppresses intestinal tumourigenesis. Nature Genetics 34:145-147.